Pharmahuasca is quite similar to mushrooms. Psilocybin is 4-PO-DMT; pharmahuasca is DMT w/ an MAOI to make it orally active. Unlike mushrooms, however, there is no tolerance build up w/ low dose DMT; it's cool how you can just keep easily dipping into the mindstate.
The most common form of pharmahuasca is moclobemide + DMT, but I don't recommend using moclobemide.
I have also utilised pharmaceutical MAO-inhibitors like moclobemide, prescribed for depression, but came to feel they were not as beneficial as rue or ayahuasca vine. Most people who took them noticed a strange chemical feeling, and the experiences they provided were good, but after a time I came back to Syrian rue and ayahuasca vine, as the experiences they engendered were richer and seemed more useful to me.
Articulations: On the Utilisation and Meanings of Psychedelics. Julian Palmer. 2014. Anastomosis Books. ISBN 9780992552817. 4. Ayahuasca / The Religion of Ayahuasca
I recognise that chemical feeling, described here. I'm going to look into sourcing pirlindole
talk_to_yourself, 2024-05-17,
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Moclobemide also doesn't last long and only allows for a short experience.
Last week I received a prescription for the MAOI, Parnate. Not only is Parnate considered to be a good antidepressant, it's also known for having little to no side effects, for example:
"Little adverse effect on sexual function (possible benefit from dopaminergic action)" (Gillman 2011*)
This may be because Parnate is similar to a chemical in our bodies, beta-phenethylamine. It's actually more similar to amphetamine; amphetamine is short for alpha-methyl-phenethylamine. But don't worry, it's like amphetamine with a strait jacket on; it does not release that much dopamine no matter how much you take. In spite of the massive dopamine depletion from abuse, amphetamine has a very clean initial effect; Parnate is amphetamine with a speed limit, so it's a nice, clean effect without the abuse potential. Pirlindole, mentioned above, is structurally similar to serotonin; both chems are classified as indoles.
amphetamine ‖ phenylpropanamine
Parnate ‖ phenylcyclopropanamine
Parnate is an irreversible MAOI, which means that the effect cannot be reversed. Reversible MAOIs have a safety valve, you could say; if an excess of tyramine is ingested, the MAOI is knocked off the receptors allowing the body to dispose of tyramine, which is a poison. The body loses this capability for ~2 weeks after ingestion of an irreversible MAOI because irreversibles work by poisoning the MAO enzymes. Aside from preventing defense against tyramine, which is rarely found in substantial amounts, MAOIs don't elicit that much risk, except for eliciting a sensitivity to serotonin and noradrenaline boosters. So, for Parnate, you do need to follow the MAOI diet and avoid certain drugs for a period of time (technically, low doses of those drugs are acceptable), but chances are you follow the diet anyway and chances are you don't use those drugs on a routine basis (e.g., MDMA). More info about the diet: https://www.shroomery.org/forums/showflat.php/Number/28975082
So, Parnate enables a nice, clean oral DMT experience with a mild speedy effect and feeling of mood stabilization. It's one of the coolest effects I've ever experienced.
I'm gonna see about mail ordering some from a foreign chemical supplier so I have unlimited access to it. Another prospect is clorgiline. It's an MAO-A only irreversible inhibitor and it too resembles amphetamine and it's, like, the most common MAOI used in scientific research, so it should be easy to find a source, and unlike Parnate, it is not a prescription, so it's perfectly legal to buy it.
It should also be noted that harmalas, the traditional ayahuasca MAOIs, have somewhat of a psychedelic effect on their own and are healthy for you, i.e., they've been found to elicit neurogenesis. But I don't like the way they make me feel, except in low doses, so I could see myself using Parnate to activate the DMT and adding a bit of harmala(s) to flavor the experience, which should be safe.** Actually,
I do like the way B. caapi tea feels, but B. caapi is expensive and it doesn't taste good. I'm curious about 6-MeO-harmalan.
More info about harmalas: https://www.shroomery.org/forums/showflat.php/Number/29131910
*
Gillman P. K. 2011. Advances pertaining to the pharmacology and interactions of irreversible nonselective monoamine oxidase inhibitors. Journal of clinical psychopharmacology, 31(1), 66–74. DOI: 10.1097/JCP.0b013e31820469ea. Table 1, p. 4
**
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