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BDD Moderators: Keif’ Richards | negrogesic
RCs A recup of my discoveries over the past.
- Thread starter Gaffy
- Start date
Here I'll be posting my best inventions, selected for their binding profiles.
It'll take some time to finish this thread (if I ever do as I've litterally thousands of chemicals to sort out and run through, and test with the SAR machine), but I'll post what I think deserves to be posted.
We'll start with Ketamine and Ephenidine analogs I've invented, and switch to BTCP analogs which will permit us to switch to DRIs: (And from there it'll be pretty random, as I can't classify all my compounds)
Ketamine
PCP
Ephenidine
Seven ringed Ketamine,
CycloHeptylKetamine : C1(C(CCCCC1)=O)(C2=CC=CC=C2)N(C)[H]
Seven ringed Methoxetamine,
CycloHeptylMethoxetamine: C1C(C(CCCC1)(C2=CC=CC(=C2)OC)NCC)=O
Adding a benzene group to the cycloheptyl:
3-MeO-PCPy with a PhenylCycloHEptyl ring: C1CC(CCC2=C1C=CC=C2)(C3=CC=CC(=C3)OC)N4CCCC4
a little extra
(With very interesting SARs)
MorphoKetamine: ClC1=C(C=CC=C1)C1NCCOC1C1=CC=CC=C1
PCP with a N-PhenylPiperazine
PCPP: C1=CC=C(C=C1)N2CCN(CC2)C3(CCCCC3)C4=CC=CC=C4
BTCPP, BTCP with a phenylpiperazine
BTCPP: C1=CC=C(C=C1)N2CCN(CC2)C3(CCCCC3)C5=CC4=CC=CC=C4S5
Three analogs between Ephenidine and BTCP:
BTPhenEthylPiperidine : C(C(N1CCCCC1)C1=CC2=C(S1)C=CC=C2)C1=CC=CC=C1
BTPhenEthylPyrrolidine: C12=C(C=CC=C1)SC(=C2)C(CC3=CC=CC=C3)N4CCCC4
BTBKPhenEthylEthylamine: C12=C(C=CC=C1)SC(=C2)C(C(C3=CC=CC=C3)=O)N(CC)[H]
The morpholine analog of ketamine applied to BTCP:
MorphoBTCE: C1COC(C(N1)C1=CC2=C(S1)C=CC=C2)C1=CC=CC=C1
Mono-methylated alpha-phenylated tryptamine, a SNDRI that stands out:
N-Methyl-Alpha-Phenyl-Tryptamine: C1=CC=CC2=C1C(=C[N]2)CC(C3=CC=CC=C3)NC
Its N-Pyrrolidino analog
5-MeO-AMT
C1(=CC=C2C(=C1)C(=C[N]2)CC(N([H])[H])C)O
Cocaïne analogs: probably my best inventions
I Don't know what to call these, but they're wonderously promising
COC(=O)C(CC1=CC=CC=C1)C1CCCN1
The N-Methyl, even more promising
C1(=CC=CC=C1)CC(C(=O)OC)C2CCCN2C
The local anaesthetic version, it's got high HERG activity:
C1=CC=CC=C1C(OCC(C(OC)=O)C2CCCN2[H])=O
The N-Methyl version, with even more HERG activity, which makes it cardiotoxic
COC(=O)C(COC(=O)C1=CC=CC=C1)C1CCCN1C
An outstanding one,both SNDRI and MOR (!)
N'-N-Methyl version
2-FA Light
C1(=CC=CC=C1OC2CCN(CC2)[H])F
4-MethylMethylphenidate N-pyrrolidine analog
C1=CC=CC=C1C(C(N2CCCC2)=O)C3CCCCN3[H]
PVP Methylphenidate: Surprisingly good
C1=CC=CC=C1C(C2CCCC3CCCN23)C(OC)=O
N-pyrrolidino Version
3-MeO-PhenEtrazine
C1=C(C=CC=C1C2C(CC)N(CCO2)[H])OC
CyclopentylEthylCathinone
CCNC(C1CCCC1)C(=O)C1=CC=CC=C1
Two Ketobemidone variants, go guess how I guessed
BTKETO1
C1=CC=C2C(=C1)C=C(S2)C3(CCN(CC3)C)CN4CCCC4
BTKETO2
C1=CC=C2C(=C1)C=C(S2)C3(CCN(CC3)C)C(N4CCCC4)=O
Should be opioïd, is Dopaminergic and Opioïd sigma active:
C2(CC(CC1=CC=CC=C1)N(CC2)[H])(C(=O)CC)C3=CC=CC=C3
Ketobemidone analog:
C1(C(CN(CC1)C)=O)(C(=O)CC)C2=CC(=CC=C2)O[H]
Chlorphenamine derived Antihistaminergic Psychedelics, or chillaxed tripping!
5-Meo one
C1=C(C=CC2=C1C(=C3C=CC=C[N]23)CCN(C)C)O
Chlorphenamine inspired
C1=CC(=CC2=C1C(=C3C=CC=C[N]23)CCN(C)C)Cl
5-Meo DIPT one
C1=C(C=CC2=C1C(=C3C=CC=
I meant the picture I committed to naming GAFFY in the Name-A-Molecule thread ^^ This one:
A-AVP
Alpha-AziridineValeroPhenone
Edit:I just realised the difference between pyrrolydine and pyridine.. I will update that asap!
Done
Ethyl 2-(Piperidino)-1-3'-hydroxyphenylcyclohex-3-ene-1-carboxylate
I also like this one. Can't post STP results but it seems lile a winner.
8-Ethyl-7-PHenYLoctahydrOIndoliziNE
EPHYLONE
Dopaminergic cannabinoid, shares androgen and estrogen liability. Should be euphoric.
Now let'd take the above and make it a bit more expensive, to get pretty much similar effects.. As of yet, a gold holding dopamine agonist etc etcSwissTargetPrediction
swisstargetprediction.ch
Just a little example of the many possibilitys
Or
