A hypothetical question about "reverse tolerance"

[Ray K. Hessel]

Considering the down regulation event which occours to cause tolerance in opioid receptors, could there be a way to "up-regulate" your receptors with some sort of chemical?

I'm talking about taking some sort of substance which would prevent opioids from reaching your receptors for an extended period of time, increasing their sensitivity, with the eventual effect of a euphoric withdrawl.

???

 

[Sphinx (Afterlife)]

Considering the down regulation event which occours to cause tolerance in opioid receptors, could there be a way to "up-regulate" your receptors with some sort of chemical?

I'm talking about taking some sort of substance which would prevent opioids from reaching your receptors for an extended period of time, increasing their sensitivity, with the eventual effect of a euphoric withdrawl.

???

an euphoric withdrawal is smoking crack while withdrawing from the hero', dont everyone know that?

look into endocytosis. I beleive thats the kind of shit you are wondering about in which case with the right keywords theres lots of info to find on the net and plenty chemicals that alter such, some available from supply houses if I recall correctly.

 

[BilZ0r]

Well there are various opioid ligands that don't cause downregulation as bad, and various proteins which when negated, stop downregulation. Further, kinase inhibitors probably would stop downregulation... but ultimately, these are far far far outside the reach of your average user. There's speculation about co-administartion of NMDA antagonists, a la [1].

 

[Ray K. Hessel]

thanks for the replies!