Benzos a diazepam active metabolite as a bz partial agonist?

[mygreenbic]

I believe in my family studying of all things pharmacological, I believe I came across one article stating that desmethyldiazepam is a bz receptor partial agonist. I apologize that I don't remember where I read this because it became of concern to me, and I'll tell you why-
I have been on benzodiazepines for the the last decade of my life- namely: clonazepam, temazepam, flurazepam, and occasionally alprazolam (one of my least favorite and IMO most overrated (memetically so) of all of the recreational benzodiazepines.
It has been increasingly difficult to acquire diazepam but I know someone who often times would give me a couple when I am in severe withdrawal from the other bzs. However, I have never taken Valium (diazepam) while other benzos were in my system.
Recently I acquired an Rx for 3 10mg pills of diazepam daily because my Psych was switched to some dea whipped jerk of a doctor and he drastically started to cut my other benzo doses.
In a panic I convinced my physician to write a prescription for diazepam which after research and finding out that DD is one of the active metabolites is why this subject resonates with me so.
If in fact the main active metabolite of vacuum— desmethyldiazepam is in fact a partial agonist, will taking valium with clonazepam or other full agonists in my system cause a precipitated withdrawal ( in much the same way buprenorphine would with other full agonist opiods)?
If not why?
Thank you
mygreenbic
@sp0r412

 

[rymerkk]

no, diazepam or desmethyldiazapem wouldn't cause precipitated withdrawals if other benzos are in your system in the way bupe would cause them if say morphine was in your system. yes, desmethyldiazepam is a partial agonist, but there are other metabolites that are full agonists and a little (correct me if i'm wrong) diazepam stays unchanged (which is a full agonist as well). If you had, say, xanax in your system then popped a valium you would just have synergistic effects rather than precipitated withdrawals. i know this because i have taken alprazolam, then a few hours later some diazepam and just experienced synergy of the two substances.

edit: here's a thread i found on the subject: http://www.bluelight.ru/vb/threads/39119-Combining-Valium-and-Xanax
mixing depressants, as stated in the thread, isn't the BEST idea but done correctly can be safe.

 

[tricomb]

It's not a agonist, that would cause PWD, it's an antagonist, for example, flumazenil.

 

[NeighborhoodThreat]

The reason buprenorphine causes precipitated withdrawals is because buprenorphine isn't just a partial agonist, its a competitive partial agonist for the mu-opioid receptor. It pushes other opiates out of the receptor.

Nordiazepam/nordazepam (desmethyldiazepam) is a partial agonist but it is not any more competitive than any other benzodiazepine and therefore won't "push out" another benzodiazepine activating the receptor.