I was doing some reasearching and found that the majority say to just take it after a roll and never before. After so long I finally decided to give it a try and will have some for after my roll on tuesday. Now I took 200 mgs a day from wednesday to saturday then took 50 mgs this morning. Got a nice mood boost from it but I've read it's dangerous to take beforehand because of ss. I'm only going to take it after my rolls now but will this have any negative effect on my roll tuesday night or not?
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MDMA &
Empathogenic
Drugs
Welcome Guest! -
5htp before mdma
- Thread starter mj1945
- Start date
Folley
Bluelighter
Just be sure to wait a good 24+ hours between 5-HTP and MDMA doses and you should be fine.
epic11
Bluelighter
Also make sure to avoid foods heavy in L-Tryptophan because the conversion to 5-HTP is dangerous before MDMA. *sarcasm*
I've said it before and I doubt anyone will listen, but, I see no strong, convincing scientifical reason why 5-HTP & MDMA is dangerous. Sure 5-HTP is the precursor to serotonin. Sure MDMA releases serotonin. However, 5-HTP doesn't cause anymore serotonin to be released into the synapse than would usually be released. Serotonin Sydrome is a very rare condition resulting from an extreme amount of serotonin in the synapse. It usually occurs when drugs have a strong synergy. E.G. combining MDMA with a Monoamine Oxidase Inhibitor (MAOI). The MDMA releases serotonin and the MAOI blocks the enzyme that breaks serotonin down so it stays in the synapse = dangerously high serotonin. Basically, you can't get rid of the serotonin that has been released. At best, you'd have an extremely long & intense roll. At worst, you could develop SS. Another possible cause is combining MDMA with a drug that also releases serotonin (Tramadol, MKAT maybe? Providing they work through differing mechanisms).
Like I said, rather ironically, if 5-HTP was really dangerous then you could argue that consuming lots of L-tryptophan rich foods before MDMA is also dangerous.
L-Tryptophan > 5-HTP > 5-HT.
I've said it before and I doubt anyone will listen, but, I see no strong, convincing scientifical reason why 5-HTP & MDMA is dangerous. Sure 5-HTP is the precursor to serotonin. Sure MDMA releases serotonin. However, 5-HTP doesn't cause anymore serotonin to be released into the synapse than would usually be released. Serotonin Sydrome is a very rare condition resulting from an extreme amount of serotonin in the synapse. It usually occurs when drugs have a strong synergy. E.G. combining MDMA with a Monoamine Oxidase Inhibitor (MAOI). The MDMA releases serotonin and the MAOI blocks the enzyme that breaks serotonin down so it stays in the synapse = dangerously high serotonin. Basically, you can't get rid of the serotonin that has been released. At best, you'd have an extremely long & intense roll. At worst, you could develop SS. Another possible cause is combining MDMA with a drug that also releases serotonin (Tramadol, MKAT maybe? Providing they work through differing mechanisms).
Like I said, rather ironically, if 5-HTP was really dangerous then you could argue that consuming lots of L-tryptophan rich foods before MDMA is also dangerous.
L-Tryptophan > 5-HTP > 5-HT.
Folley
Bluelighter
^ I'm less worried about it being dangerous than I would be about it dulling the roll as many anecdotal reports have claimed
Lightning-Nl
Bluelighter
- Joined
- Nov 11, 2012
- Messages
- 1,245
Taking 5-HTP right before dropping MDMA would be an incredibly bad idea.
Serotonin Syndrome has a good possibility of being induced.
Serotonin Syndrome has a good possibility of being induced.
hazmatz
Bluelighter
- Joined
- May 26, 2013
- Messages
- 134
Hmm...before I knew any better, my (now ex) girlfriend told me that taking 5htp before a roll ENHANCED it so I went to a music festival and dropped 5htp a couple of hours before rolling and rolled like 4 times that weekend and had 5htp after each roll as well...I don't think I had any negative effects, but i didnt feel like my rolls were enhanced...5htp after a roll is very important though, it will almost completely remove the comedown (at least for me it does)
You may be, but many still fear 5-HTP & MDMA causing Serotonin Syndrome which is unneccessary.
I also see no scientific reason why it would dull the experience. If anything, and this is clutching at strings, it would enhance the MDMA experience through a minimal increase in Serotonin release because more was available because of the 5-HTP. Certainly not enough to induce Serotonin Syndrome. Perhaps the anecdotal reports are merely coincidence? Set & Setting wasn't right, not enough MDMA, not even MDMA. Who knows. Just like when I took 5-HTP then got drunk. For that evening I felt an increased empathy and attributed that to the 5-HTP beforehand. Instead it was due to having a nice conversation with my ex-girlfriend which helped iron our previous differences and be back on speaking terms.
Just some thoughts.