Found the following information on B6 and 5htp in the healthy living section
quoting - 'photomind'
Simple. B-6 in any oral form (pyridoxine HCL, pyridoxamine, P5P) taken at the same time as or within 2-3 hours before (depending on dosage and form) will enhance peripheral conversion to Serotonin. Peripheral Serotonin does not cross the Blood-Brain Barrier and will act on intestinal smooth muscle. This means nausea, diarrhea, possible spasms and increases in hepatic MAO-A. Leave it alone. Use 5-HTP without B-6 and more will cross the BBB and be converted in the CNS to Serotonin, Melatonin, and (if enough methyl donors are around) DMT. Long term use of 5HTP will result in increased MAO-A in the CNS and decreased tryptophan hydroxylase to compensate. Re-uptake transporters can also increase. In Short, 5HTP alone boosts CNS Serotonin rapidly. Take your vitamins later. You don't need as much B-6 as you think and P5P orally is a waste of money. Try it out and see what I mean. Less nausea and a lower dosage is a good thing. Tryptophan can be much more practical and is virtually unaffected by B-6 supplements. 5HTP is to Serotonin as L-DOPA is to Dopamine. B-6=bad side effects. Dosage? Well, Don't over do it with 5HTP, especially on SSRI's. Hours of Vomiting and hyperthermia. Any Questions?