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4-methyl cathinone?

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sackynut

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MOD EDIT:

IF YOU ARE LOOKING FOR INFORMATION REGARDING THIS CHEMICAL, PLEASE SEE THE UPDATED THREAD HERE:

4-MC (4-methylcathinone / nor-mephedrone)

Sorry if the thread title is wrong, already been posted, or is completely irrelevant. And sorry about the thread title, I just realized after posting that cathinone wouldnt apply to this chem.

But, could one produce 4mmc without the second m?

Example: MDMA --> MDA, loses that N-methyl but everything else remains the same.

So could you remove that specific Methyl from 4mmc and have a decent chem? I just realized removing that methyl would make it no longer a cathinone, but would it still be a stable psychoactive molecule? Maybe someone could try to guesstimate its effects based on the profiles of other cathinones (or similar chems)?

Thanks.
 
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He's talking about removing the N-methyl group to leave paramethylcathinone.

Paramethylamphetamine is highly serotonergic compared to its non-methylated counterpart, so I'm guessing this compound would be a mild entactogen somewhere in between cathinone and mephedrone in effects.
 
danceofdays said:
He's talking about removing the N-methyl group to leave paramethylcathinone.

Paramethylamphetamine is highly serotonergic compared to its non-methylated counterpart, so I'm guessing this compound would be a mild entactogen somewhere in between cathinone and mephedrone in effects.
Click to expand...

exactly what I was looking for, thanks for the answer!

i cant seem to find any data on this chem (and Im in the process of getting my journal access back), could you post a source for the "highly serotonergic" info? thanks
 
danceofdays said:
He's talking about removing the N-methyl group to leave paramethylcathinone.

Paramethylamphetamine is highly serotonergic compared to its non-methylated counterpart, so I'm guessing this compound would be a mild entactogen somewhere in between cathinone and mephedrone in effects.
Click to expand...
Would not the affects of paramethylamphetamine compared to paramethyl methamphetamine be more relevant?
 
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Cathinone is pretty unstable and degrades to cathine/norephedrine, there's a reason nobody makes straight primary amine cathinones. I would imagine p-methylnorephedrine would be fairly heavy on the side effects.
 
fryingsquirrel said:
Would not the affects of paramethylamphetamine compared to paramethyl methamphetamine be more relevant?
Click to expand...

That's what I would have thought. Look at how those two chems differ, and then we may be able to draw some theoretical comparisons.

Does Cathinone have any affinity for SERT? I know that Methcathinone has some, same with Amphetamine and Methamphetamine. But perhaps Cathinone's lack of affinity for SERT would make paramethylcathinone inert as an entactogen type substance. Would likely make it considerably less potent too, if the potency of paramethylmethcathinone to methcathinone is anything to go by.
 
I raise this from the depths.

It is circulating now. Any new info?

Purely curious
 
Given the widespread reports on what happened to those using para-methylamphetamine, I wouldn't fuck this one with jimmy saville's anthrax-coated dick.
 
tamarinds said:
I raise this from the depths.

It is circulating now. Any new info?

Purely curious
Click to expand...

Well I dought it is what they say it is (cause of the unstable struktur). Id stay away...
Wasnt there a there some topic on this already? Ill have a look
 
Its been done though, primary amine cathinone prodrugs, in the form of the pthalimidopropiophenone, which in the unsubstituted cathinone appeared to be active.
 
ebola? said:
Is it? It should be hard to synthesize and relatively unstable. I think something else might be 'circulating', being sold as 4-methyl-cathinone.

ebola
Click to expand...

highly likely. if it were real, most would probably have dimerized before it arrived at the person who ordered some.
 
sackynut said:
MOD EDIT:

IF YOU ARE LOOKING FOR INFORMATION REGARDING THIS CHEMICAL, PLEASE SEE THE UPDATED THREAD HERE:

4-MC (4-methylcathinone / nor-mephedrone)

Sorry if the thread title is wrong, already been posted, or is completely irrelevant. And sorry about the thread title, I just realized after posting that cathinone wouldnt apply to this chem.

But, could one produce 4mmc without the second m?

Example: MDMA --> MDA, loses that N-methyl but everything else remains the same.

So could you remove that specific Methyl from 4mmc and have a decent chem? I just realized removing that methyl would make it no longer a cathinone, but would it still be a stable psychoactive molecule? Maybe someone could try to guesstimate its effects based on the profiles of other cathinones (or similar chems)?

Thanks.
Click to expand...


broken link
 
To clarify you mean removing the methyl group that's the ch3 group attached to the nitrogen not the one attached to aromatic benzene

Or

Like

Methamphetamine to amphetamine
 
This would have to be protected as a pthalimidopropiophenone, to serve as a pro-drug after cleavage by HCl in the stomach, primary beta-ketoamines are unstable as hell and dimerize to form pyrazine condensation products, and turn to shite quicker than a politician opening their mouths emits faecal matter.
 
Considering the vendor putting this out (they're also retailing genuine rti-111) I'd hazard a method/salt that increases stability ala. Bk-2-cb.
 
I found BK-2C-B to be...well it might as well have been 2C-At for how stable the stuff was. H2O soluble, not sure of the counterion but it was difficult to get into the body and actively.
 
The active doses of bk-2C-B as well duration of effects reported by different people differed substantially, which makes it quite unlikely that the instability of the compound was the only factor at play. Anyway, it doesn't seem like the degradation of cathinones rapidly goes all the way to the corresponding pyrazines as some amounts of rearranged isocathinones are often found in samples of cathinones, which must come from the hydrolysis of dihydropyrazines (still, keep in mind secondary amine cathinones can't form pyrazines and the dimer formed is necessarily a dienamine!). Those dihydropyrazines are diimines after all and the yield of imine formation from a corresponding ketone or aldehyde is highly dependent on the conditions like the presence of water which is ideally removed from the reaction mixture as it forms to push the equilibrium towards imine. So as long as access to oxygen and light is kept to minimum, the degradation should not be fast enough to be of much significance. The appearance of the purple colour alone (which may come from a substituted 2,5-diphenylpyrazine, it's a conjugated aromatic after all) is not really a good indicator of the extent of the degradation as even small quantities of the degraded product may give colouring.

Perhaps this problem was studied and the results published in some journal of forensics.
 
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