3,4-methylenedioxyephedrine

[dunwich]

Has anyone heard of this substance actually being created/used?
It seems like a pretty obvious one to synth and try, if one were so inclined. On Ask Dr. Shulgin, Shulgin has said that he thinks MDMA *might* even be converted to the ephedrine analog in the brain. Even tho the hydroxyl group is polar and might have more trouble than MDMA/MA and methylone/cat in crossing the BBB, ephedrine is still active itself. So, I would think 3,4-methylenedioxyephedrine would be too, but who knows i guess. Maybe the relationship between it and MDMA would be like between ephedrine and MA....similar effects but the ephedrine potency is way less. And if 3,4-methylenedioxyephedrine actually is worth consuming, it wouldnt even be outlawed in the US via the Analog Act, unlike methylone. Seems like a pretty interesting thing to explore...

here is the link to the Ask Dr. Shulgin

 

[fastandbulbous]

It would chance to have a really undesirable amount of adrenergic side effects on the body ;think of the comparison between the three non-ring substituted compounds - methamphetamine, methcathinone & ephedrine. Methamphetamine (+ methylenedioxy ring=MDMA) has excellent blood brain barrier penetration with not too much in the way of unpleasant peripheral side effects for a one off dose; methcathinone (+ methylenedioxy ring = methylone) is sligtly more physical in its effects but still pretty much side effect free. Ephedrine on the other hand has a shit load of peripheral side effects due to the increased dose required to get a decent dose into the CNS. Ephedrine also partially acts directly at adrenergic receptors (unlike methamphet & methcat). Sticking a methylenedioxy ring on to ephedrine would probably make it even more likely to have direct activity at adrenergic receptors (oxygens on the 3&4 pos of the benzene ring being the same as catecholamine neurotransmitters).

The dose of methylenedioxyephedrine required to give an acyive dose across the blood brain barrier had chance to make the peripheral side effects (heart racing, nausea etc) unbearable.

BTW the US analogue act would cover methylenedioxyephedrine as the only difference between that and MDMA is the group on the benzylic carbon (-H in MDMA; -OH in ephedrine derive and =O in methylone)