N&PD Moderators: Skorpio | thegreenhand
1. A series of N-substituted tryptamines was compared with a series of beta-carbolines in rats trained to discriminate LSD (0.1 mg/kg) from saline.
2. Intermediate levels of substitution were elicited by MDMT (76.4% ), DMT (77.9% ), and DET (48.7% ). 6-F-DET produced 41.3% LSD-appropriate responding at a dose of 6.0 mg/kg but only 4 of 8 subjects completed the test session thus precluding statistical analysis. Bufotenine (25.8% ) also failed to substitute. Although none of the tryptamines substituted completely for LSD, the pattern of substitution is consonant with what is known of their activity in humans. MDMT, DMT, and DET are well established in the literature as hallucinogens but the same cannot be said for 6-F-DET and bufotenine.
3. Of the beta-carbolines tested, none substituted for LSD completely and only harmane elicited intermediate substitution (49.5% ). No significant generalization of the LSD stimulus to 6-methoxyharmalan, harmaline, or THBC was observed. Thus, in contrast to the tryptamines, scant ability to substitute for LSD was observed in the beta-carbolines tested.
4. Taken together, the present data indicate that the representative tryptamines employed in the present study exhibit greater similarity to the LSD stimulus than do representative beta-carbolines. The receptor interactions responsible for these differences remain to be determined.
I don't see how I could pose the question any simpler: If there was a xanthine whose metabolite in the human body by any pathway was uric acid for the molecule in question (the xanthine), what would you name such a compound. ;-j (it was a question posed to everyone though, not you alone, but any answer would suffice for me ;-j )I'm not sure I understand your question.
Out of all possible configurations of a xanthine, when a simple methylene unit added will do?Not metabolically likely at all.
I meant any substitution coming off the nitrogen that eventually ended in one, not straight off of it.Methylene is R-CH2-R', where R stands for radical