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Phenethylamines 2C-B frequency of usage

scabbard

Bluelighter
Joined
Apr 2, 2024
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I'm curious if anyone has any direct experience with using 2C-B regularly (e.g. once a week or more), and what the effects were in terms of tolerance buildup and physical strain on the body. It is known that MDMA shouldn't be used too often, since it can deplete neurotransmitter reserves (or something to that effect). I've heard reports of people using it regularly and then experiencing numbness and depression. I'd like to know if the same holds true for 2C-B.

This has also been discussed here but only as a side topic.
 
I've taken a lot of 2cb.

It's taken the better part of a week dosing daily to notice any significant tolerance. I doubt you'll ever notice significant tolerance build from weekly use no matter how long you take it for. You might get bored of it though.

I've noticed zero ill-effects from my abuse save maybe for some barely noticeable HPPD.

Not endorsing daily or even weekly 2cb consumption btw. Don't do that.
 
That's great to hear. And no, I'm not planning on taking 2C-B as a replacement for my morning oatmeal. But it's definitely good to know that very frequent usage has not led to any noticable negative side effects.
 
I would say that the risks of using various psychedelics frequently over a long period of time are mostly unknown. One possible risk that is not as yet firmly established is the possibility of cardiac valvulopathy, which is associated with drugs that have activity at 5-HT2B receptors. Most psychedelics including 2C-B and also MDMA have a fairly high affinity at 5-HT2B. In fact, some evidence suggests that 5-HT2B activity is necessary for entactogenic effects from MDMA and that it may enhance serotonin release.

The potential for valvulopathy from psychedelics is hypothetical on the basis of their 5-HT2B activity, but no systematic study has established how great this risk is in practice. Apart from potentially major differences in action between different psychedelics, there is also the question of how frequency of use comes into play. Drugs proven to cause valvulopathy were usually taken on a daily basis. Few people use psychedelics that way. A single study has suggested an association between people who frequently used MDMA (like every weekend) for an extended period of time and abnormal EKG, but it involved a pretty small sample and (IIRC) didn't adequately control for other factors which may have been at play.

As for post-trip serotonin depletion, psychedelics do not seem to cause this to anywhere near the extent that MDMA does. I suspect that 5-HT2B induced serotonin release is more controlled (it is more of a release enhancement than an uncontrolled release) and limited by available reserves so as to not exhaust them. MDMA on the other hand may force open the serotonin transporter, allowing serotonin reserves to leak out uncontrolled until they're exhausted.

All I can say is to listen to your body and keep in mind nothing is for certain. I use psychedelics frequently (every few weeks or so) to treat chronic disease, and I've basically accepted the risk of valvulopathy and whatever unknown risks there may be as worth it for the medicinal value I get. So far my health is far better off for it.
 
I would say that the risks of using various psychedelics frequently over a long period of time are mostly unknown. One possible risk that is not as yet firmly established is the possibility of cardiac valvulopathy, which is associated with drugs that have activity at 5-HT2B receptors. Most psychedelics including 2C-B and also MDMA have a fairly high affinity at 5-HT2B. In fact, some evidence suggests that 5-HT2B activity is necessary for entactogenic effects from MDMA and that it may enhance serotonin release.

The potential for valvulopathy from psychedelics is hypothetical on the basis of their 5-HT2B activity, but no systematic study has established how great this risk is in practice. Apart from potentially major differences in action between different psychedelics, there is also the question of how frequency of use comes into play. Drugs proven to cause valvulopathy were usually taken on a daily basis. Few people use psychedelics that way. A single study has suggested an association between people who frequently used MDMA (like every weekend) for an extended period of time and abnormal EKG, but it involved a pretty small sample and (IIRC) didn't adequately control for other factors which may have been at play.

As for post-trip serotonin depletion, psychedelics do not seem to cause this to anywhere near the extent that MDMA does. I suspect that 5-HT2B induced serotonin release is more controlled (it is more of a release enhancement than an uncontrolled release) and limited by available reserves so as to not exhaust them. MDMA on the other hand may force open the serotonin transporter, allowing serotonin reserves to leak out uncontrolled until they're exhausted.

All I can say is to listen to your body and keep in mind nothing is for certain. I use psychedelics frequently (every few weeks or so) to treat chronic disease, and I've basically accepted the risk of valvulopathy and whatever unknown risks there may be as worth it for the medicinal value I get. So far my health is far better off for it.
I agree about the 5HT2b risk here and it's why I don't daily dose it anymore, but I've daily dosed from my boyfriend and I killing a gram over 6 weeks, to microdosing 5-8mg a day. Tolerance never noticeably built for me I just stopped getting nausea or body load.
 
I would say that the risks of using various psychedelics frequently over a long period of time are mostly unknown. One possible risk that is not as yet firmly established is the possibility of cardiac valvulopathy, which is associated with drugs that have activity at 5-HT2B receptors. Most psychedelics including 2C-B and also MDMA have a fairly high affinity at 5-HT2B. In fact, some evidence suggests that 5-HT2B activity is necessary for entactogenic effects from MDMA and that it may enhance serotonin release.

The potential for valvulopathy from psychedelics is hypothetical on the basis of their 5-HT2B activity, but no systematic study has established how great this risk is in practice. Apart from potentially major differences in action between different psychedelics, there is also the question of how frequency of use comes into play. Drugs proven to cause valvulopathy were usually taken on a daily basis. Few people use psychedelics that way. A single study has suggested an association between people who frequently used MDMA (like every weekend) for an extended period of time and abnormal EKG, but it involved a pretty small sample and (IIRC) didn't adequately control for other factors which may have been at play.

As for post-trip serotonin depletion, psychedelics do not seem to cause this to anywhere near the extent that MDMA does. I suspect that 5-HT2B induced serotonin release is more controlled (it is more of a release enhancement than an uncontrolled release) and limited by available reserves so as to not exhaust them. MDMA on the other hand may force open the serotonin transporter, allowing serotonin reserves to leak out uncontrolled until they're exhausted.

All I can say is to listen to your body and keep in mind nothing is for certain. I use psychedelics frequently (every few weeks or so) to treat chronic disease, and I've basically accepted the risk of valvulopathy and whatever unknown risks there may be as worth it for the medicinal value I get. So far my health is far better off for it.
I totally agree with you, no one knows for sure. But I'm also in alignment with your way of thinking. Sure, maybe taking psychedelics on the regular does increase (potentially, not for certain) the risk of cardiac valvulopathy. OK, that's a risk. Another thing that isn't a just a potential but I unfortunately know quite well is having my body in a fight, flight and freeze state, often simultaneously which exacerbates the effects, on a daily basis. My body is in overdrive almost 24/7. That's not a potential, that is a very well known yes. And the effects on my health from that also are quite certainly detrimental.

So to me it's a no brainer.
 
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The most I’ve seen anyone use it was the Shulgins, an average of once a month over 10 years.

I'm not at all surprised by this, but I'm curious where you got this information. Also, did the Shulgins stop using 2C-B after 10 years for some reason? Perhaps they had to "flush it all" when the DEA showed up and rescinded the licenses? I suspect they had many fallback options and probably kept using 2C-B, even if less often after that. A few other things are worth noting with regard to the Shulgins. First, Sasha had to have valve replacement surgery. It is but an anecdote suggesting that heavy psychedelic use may cause valvulopathy. Second, Sasha often took a great many drugs with as little as 3 days between experiments, and he did so over a very long period of time. He was a heavy psychedelic user by any standard. Third, Sasha had a period in his life in which he used a lot of MDMA, often with very little time between doses, which could have been a major factor in his valvulopathy as well.

I anticipate keeping my 2C-B usage to twice a year or so. It helps a lot that I have other good things to choose from. I also like to mix things up so I don't get bored or overly adapted to any one drug.
 
I'm not at all surprised by this, but I'm curious where you got this information. Also, did the Shulgins stop using 2C-B after 10 years for some reason? Perhaps they had to "flush it all" when the DEA showed up and rescinded the licenses? I suspect they had many fallback options and probably kept using 2C-B, even if less often after that. A few other things are worth noting with regard to the Shulgins. First, Sasha had to have valve replacement surgery. It is but an anecdote suggesting that heavy psychedelic use may cause valvulopathy. Second, Sasha often took a great many drugs with as little as 3 days between experiments, and he did so over a very long period of time. He was a heavy psychedelic user by any standard. Third, Sasha had a period in his life in which he used a lot of MDMA, often with very little time between doses, which could have been a major factor in his valvulopathy as well.

I anticipate keeping my 2C-B usage to twice a year or so. It helps a lot that I have other good things to choose from. I also like to mix things up so I don't get bored or overly adapted to any one drug.
It’s just my anecdotal summary of the reference notes of the Shulgins. More Sasha than Anne.

There’s no record of further trip reports after 1992. However, it’s clear something was still going on as the doco “dirty pictures” recorded them having a trip.

Additionally there were still a few compounds they explored early 2000s. Ie 2c-b-fly.

But I think 2c-b once a week or once every couple of weeks, based on my own experience, is going to do little in the way of damage.

Honestly, even MDMA is quite fine if you do a regular dose, with antioxidants after the experience and a good night sleep.

But as they say, know the risk, know the reward, then make the decision.
 
every time ive done it 2 days in a row, the 2nd day was quite diminished

but ive read that this varies from person to person


once a week is my favorite

oh and if i do acid within a couple days before 2cb, it doesnt work too good either

so always do 2cb first if you have plans to do some different psychedilcs within a week or shorter - always do acid last
 
Not that I know from personal experience, but I can’t see how any psychedelic would not cause a tolerance. But I guess it’s an individual thing.
 
Not that I know from personal experience, but I can’t see how any psychedelic would not cause a tolerance. But I guess it’s an individual thing.
Phenethylamines are weird, but just about everyone finds 2cb unique in it's tolerance profile in that it doesn't really have one. I've heard this put down to a lack of 5ht2a agonism but I'm not sure if that's definitive or just everybody's best guess.
 
Phenethylamines are weird, but just about everyone finds 2cb unique in it's tolerance profile in that it doesn't really have one. I've heard this put down to a lack of 5ht2a agonism but I'm not sure if that's definitive or just everybody's best guess.
Also DMT fits in there with some non conventional psychedelic tolerance. So I believe 2C-B could follow its own rules. Who knows. But yeah funny how LSD is almost less than half of the effect if taken 2 days in a row (for me), and DMT can be hit a few times in a row.

Ah but as I was typing i see Leprechaun said even LSD worked 2 days in a row. I mean it does for me if I double it. But very interesting how it varies from people.
 
Ah but as I was typing i see Leprechaun said even LSD worked 2 days in a row. I mean it does for me if I double it. But very interesting how it varies from people.
Yeah I get essentially zero effects if I dose the day after a trip. LSD, shrooms, AL, most everything I have tried (other than DMT) gives me pretty long lasting, instant tolerance. Even if I wait a week it isn't the same. At minimum I take 2 weeks of abstinence otherwise it'll just be a bunch of wasted dope. Not an overwhelming amount of waste, but I'm frugal.
 
Was doing some lurking and this thread is interesting and sorta related. It's an old one though so it touches a lot of substances
 
I've not taken 2c-b daily for a week, but I have taken it multiple days in a row. While I would say there was tolerance, I didn't find it very significant.

I would say once a week is probably fine, the long term effects of 5ht2b agonism may creep up. My frequency of use has probably laid around 6x a year, but there have been years that I was probably closer to 12-15x a year.

Mainly, I don't want to get bored, which I may have to some extent. It's still an extremely versatile psychedelic, I just don't find it super challenging. Even at high doses (+30mg), I just find the intensity increases. It doesn't get any deeper.
 
I've not taken 2c-b daily for a week, but I have taken it multiple days in a row. While I would say there was tolerance, I didn't find it very significant.

I would say once a week is probably fine, the long term effects of 5ht2b agonism may creep up. My frequency of use has probably laid around 6x a year, but there have been years that I was probably closer to 12-15x a year.

Mainly, I don't want to get bored, which I may have to some extent. It's still an extremely versatile psychedelic, I just don't find it super challenging. Even at high doses (+30mg), I just find the intensity increases. It doesn't get any deeper.
The difference in intensity between a 30mg dose and 45mg dose (I'm speaking on both intranasally) is enormous, and ~45mg is where it begins to feel equally as "mystical" as mescaline does in my opinion. 70-100mg intranasally leads to an experience akin to a DMT breakthrough, but the nausea can make the incapacitating nature of such an experience obviously dangerous, so anybody doing this should definitely have a sober tripsitter around.
 
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