2-aminoindane as an analgetic/morphine like

[yaesutom]

MEDICINAL CHEMISTRY
A Series of Monographs
Volume 5: George DeStevens (Ed.). Analgetics. 1965
ACADEMIC PRESS New York and London
pages 409-410

"[..]Using tail flick method in mice Su-8629" (i.e. 2-aminoindane) "had about the same analgetic potency and therapeutic ratio as did morphine when given by the same route. Subcutaneously the substance had about one-fifth the potency and twice the toxicity of morphine. The relative analgetic equivalence of these compounds by the oral route was substantiated by using the hot plate procedure in which 25 mg/kg Su-8629 was found to produce the same degree and duration of effects as did 25 mg/kg morphine. Witkin et al. further noted that 2-aminoindane differed from morphine in that it was devoid of nalorphine antagonism, suggesting that it was not liable to cause addiction. Seevers (17) also observed that Su-8629 in doses up to 24 mg/kg caused no suppression of abstinence in 8 monkeys which were physically dependent on morphine. It was also found by Witkin et al. that Su-8629 caused some stimulation, similar to amphetamine, at high doses. 2-Aminoindane was submitted for clinical evaluation as an analgetic and it was found to be orally effective in man at a dose of 25mg given three times daily (18). However, after extensive studies with this compound in humans, the statistically significant occurence of stimulation and moderate hypertension precluded its further use in therapy."

References

17. M.H. Seevers, personal communication to Dr. A. J. Plummer, Pharmacology Division, CIBA Pharmaceutical Company, Summit, New Jersey
18. R.C. Batterman, personal communication to Clinical Investigation Division of CIBA Pharmaceutical Company, Summit, New Jersey

I've got a vial of this stuff still from a long time ago, but I do remember i did in fact feel a "numbing" effect, it did kill pain, i could pinch myself or whatever and the perception was definitely "weak". It was the same kind of numbing effect I get (although weaker) whenever i've taken 2C-P or even 2C-D.

So they are saying that they are equal only by the oral route (both 2-AI and morphine orally)? I've only taken it orally but read some reports by the sniffy snort route. Also, well here:

-he injected IV 100mg of the material and it produced a very strong high complete with a nice little rush. He has done this several times, never exceding 150mg

-Strangly it was more familiar to an opiate rush, say comparable to banging a 4mg dilaudid than to banging street meth..

At first he muscled about 60mg and actually STILL got a rush. Nice come up, great feelings of euphoria, warmth, overall excitement and thrill (possibly to finally getting the damned substance to do something!). The high (produced by muscle or IV), I would say lasts about 1 hour... Comes up in a few minutes, peaks at like 10 minutes , starts to fade at about 30 minutes and slowly fades out over the next hour or two.. Not too terrible of an ordeal.

oddly, thinking about it makes the person desire to administer another bioassay of said material...

Interesting, I may try IMing some, ..in the name of science, of course .

 

[C6H6]

There are two patents on this topic, maybe you want to look them up:
US 3060091
US 3142629

 

[fastandbulbous]

Yes, I remember reading about this while at university. I was reading a book about opiates and analgesia and the last chapter was was about the 'weird and wonderful' of which 2-aminoindane was one. It was used in a phase III trial, but withdrawn as it produced too much 'locomotor stimulation' in patients (presumably the last thing that you want for a patient with serious injuries - requiring morphine strength drugs - is for them to be trying to get up and wander up to other patient in order to obsessively gibber at them!).

Oh, and something to do with increases in blood pressure...


Then again, amphetamine is equipotent with morphine as an analgesic for some types of pain