250mg sustanon once per week is plenty for a first cycle.
Not with sust, IMHO. A lady friend of mine best summed it up...
You need more than 250 a week because when you go "on", your boys go "off" - they only respond to demand. If you inject your demand, they go to sleep.
Replacement test for you - like, if you were suddenly castrated and needed to have your testosterone supplemented exogenously as HRT - would likely be around 200mg/week (fellas, correct me if I got that part wrong). In order to feel an effect from a cycle, you need to take enough to completely replace your own test, PLUS go over.
So, suppose your boys put out 200mg a week. If you run a 50mg per week test cycle, your boys will drop down to 150mg a week and you'll still only have what you started with: 200mg/week.
If you run 250mg of test a week, you're shutting yourself down for what nets you a 50mg over normal test cycle.
If you're going to bother shutting yourself down, you might as well take enough to make the trouble worth your while.
/V