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Mental Health Coming off Invega/Xeplion (paliperidone) injections v. 9

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TonyTonyChopper said:
Your opinion , God is one and hinduism is 100% false and I will stand by that 1 million percent 😭😭😭😭😭😭😭😭😭
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They worship cows believe cows have millions of gods inside them theirs videos of them drinking cow piss and bathing in it while the cow pissing rubbing it on their face and body and bathing in cow shit pools SWIMMING in it rubbing cow shit on their face jumping in piles of it and throwing their children by force into it if your muslim or even Christian and go to india and eat beef they will KILL YOU literally slaughter you cut your head off or burn you to death ONLY FOR FUCKING EATING BEEF🤣🤣😭😭😭 thats how much they worship them bet they fuck cows and when they do they enjoy it more than fucking their wife😭😭😭😭😭
 
I've just started my recovery and have a long way to go. But I've noticed on that most people if they say they recovered they say about 80%. I'm curious to know that is this really the case. We tend to look at our past, the good old days, with rose colored blinders. "Remember when I was so great things were so great" I find myself often doing that and then really think about it and the truth is life sucked then too. Not nearly as bad but it wasn't that great. I wonder if people fully recover and are disappointed that life isn't as good as they imagine it was in hindsight. But then again it could be true maybe there is permanent damage. I'd hope not. Just curious is all, what do you guys think?
 
DontJump said:
I've just started my recovery and have a long way to go. But I've noticed on that most people if they say they recovered they say about 80%. I'm curious to know that is this really the case. We tend to look at our past, the good old days, with rose colored blinders. "Remember when I was so great things were so great" I find myself often doing that and then really think about it and the truth is life sucked then too. Not nearly as bad but it wasn't that great. I wonder if people fully recover and are disappointed that life isn't as good as they imagine it was in hindsight. But then again it could be true maybe there is permanent damage. I'd hope not. Just curious is all, what do you guys think?
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It's unfortunate but there are so many variables and each person is different. I have been reading here and /r/antipsych obsessively.
 
DontJump said:
I've just started my recovery and have a long way to go. But I've noticed on that most people if they say they recovered they say about 80%. I'm curious to know that is this really the case. We tend to look at our past, the good old days, with rose colored blinders. "Remember when I was so great things were so great" I find myself often doing that and then really think about it and the truth is life sucked then too. Not nearly as bad but it wasn't that great. I wonder if people fully recover and are disappointed that life isn't as good as they imagine it was in hindsight. But then again it could be true maybe there is permanent damage. I'd hope not. Just curious is all, what do you guys think?
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I would say I recovered 100% but I am not the person pre invega. I am totally different in a good way.

I understand other people's pain much better, more compassionate to others and this makes me happier.

I have little bit of breathing difficulty after invega, and amount of sperm returned but libido is definitely lowered than before.

I don't search porn anymore which I found little depressing at first but in other perspective I became healthier.

I don't think we "recover" to the past but our body adopt to the situation and find a new way to live with it.

I can see I will be better over time as everyday is new day for me.
 
wbga said:
I would say I recovered 100% but I am not the person pre invega. I am totally different in a good way.

I understand other people's pain much better, more compassionate to others and this makes me happier.

I have little bit of breathing difficulty after invega, and amount of sperm returned but libido is definitely lowered than before.

I don't search porn anymore which I found little depressing at first but in other perspective I became healthier.

I don't think we "recover" to the past but our body adopt to the situation and find a new way to live with it.

I can see I will be better over time as everyday is new day for me.
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Yeah that is what I was thinking that we would recover as a different person for the better. I myself have a lot more compassion now to people suffering already in the windows I'm able to feel. At first it was more mental but slowly becoming more emotional. I think it's so great all you guys are here on this forum supporting each other.

I used to be brilliant as many would tell me and I had a silver tongue I could write really good speeches and perform them at funerals and weddings. I could write a song about every other day. I'd program new software just to past the time and chase opportunities as an entrepreneur. Ran a business for years. But now it's all gone. My wings are clipped. It's so hard to think but getting better

Perhaps it was a good thing because I was also very prideful and thought I was better than everybody. Now being the dumbest person in the room I am definitely humbled. And going through the horrors this past year I'm definitely more compassionate now to anybody suffering.

I hope to recover as a better person.
 
DontJump said:
Yeah that is what I was thinking that we would recover as a different person for the better. I myself have a lot more compassion now to people suffering already in the windows I'm able to feel. At first it was more mental but slowly becoming more emotional. I think it's so great all you guys are here on this forum supporting each other.

I used to be brilliant as many would tell me and I had a silver tongue I could write really good speeches and perform them at funerals and weddings. I could write a song about every other day. I'd program new software just to past the time and chase opportunities as an entrepreneur. Ran a business for years. But now it's all gone. My wings are clipped. It's so hard to think but getting better

Perhaps it was a good thing because I was also very prideful and thought I was better than everybody. Now being the dumbest person in the room I am definitely humbled. And going through the horrors this past year I'm definitely more compassionate now to anybody suffering.

I hope to recover as a better person.
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You will become much better person as you adopt and become alright about everything that you think you are suffering right now.

All the pain actually becomes a needle that penetrate the blocked spots of mind and when you overcome it, mind become more free than ever.

I am experiencing so much more and deeper about my life and understand.

I personally experienced extraordinary things that changed who I am after invega.

I was smart than became dumb after invega but now I am much more humble and a person who live with heart than brain.

I think you know what I am saying already.
 
wbga said:
You will become much better person as you adopt and become alright about everything that you think you are suffering right now.

All the pain actually becomes a needle that penetrate the blocked spots of mind and when you overcome it, mind become more free than ever.

I am experiencing so much more and deeper about my life and understand.

I personally experienced extraordinary things that changed who I am after invega.

I was smart than became dumb after invega but now I am much more humble and a person who live with heart than brain.

I think you know what I am saying already.
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Has your cognitive abilities returned?
 
wbga said:
You will become much better person as you adopt and become alright about everything that you think you are suffering right now.

All the pain actually becomes a needle that penetrate the blocked spots of mind and when you overcome it, mind become more free than ever.

I am experiencing so much more and deeper about my life and understand.

I personally experienced extraordinary things that changed who I am after invega.

I was smart than became dumb after invega but now I am much more humble and a person who live with heart than brain.

I think you know what I am saying already.
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This is 100% true. I feel the same way. As shit as going through all of this is, it truly makes us grow immensely, should you let it.
 

AI Recovery Info​

Credit: verybigguy

​

Summary of Potential Remedies to Accelerate Recovery from Invega/Xeplion (Paliperidone)​

Neurochemical Context:
Invega/Xeplion (paliperidone) blocks dopamine D₂ and serotonin 5-HT₂A receptors, disrupting frontal cortex function (critical for motivation, emotion, and cognition). Its long-acting injectable form (half-life: 25–49 days) sustains receptor blockade for months, leading to symptoms like emotional numbness, loss of inner monologue, and apathy. Chronic use may reduce neuroplasticity (via low BDNF) and cause dopamine receptor supersensitivity, complicating recovery.


  • L-Tyrosine (500–2000 mg/day): Precursor for dopamine synthesis, countering Dâ‚‚ receptor blockade.
  • Mucuna Pruriens (100–300 mg): Contains natural L-DOPA for direct dopamine support.
  • Exercise: Aerobic activity boosts BDNF and dopamine sensitivity (e.g., 30-minute walks).
  • L-Tryptophan (500–1000 mg/day): Serotonin precursor to counteract 5-HTâ‚‚A blockade.
  • Omega-3s (EPA/DHA) (1–2 g/day): Reduce inflammation and support serotonin pathways.
  • Adaptogens (Ashwagandha, Rhodiola): Modulate stress responses and improve resilience.
  • N-Acetylcysteine (NAC) (600–1200 mg 2x/day): Restores glutathione (antioxidant) and balances glutamate.
  • Lion’s Mane Mushroom (1–3 g/day): Stimulates nerve growth factor (NGF) for synaptic repair.
  • Magnesium L-Threonate (144 mg/day): Enhances NMDA receptor function and calms glutamate overactivity.
  • CoQ10 (100–300 mg/day): Improves cellular energy production.
  • B-Complex Vitamins: Critical for dopamine/serotonin synthesis (B6, B9, B12).
  • Probiotics (e.g., Lactobacillus rhamnosus): Improve gut health, linked to dopamine/GABA production.
  • Cold Exposure (cold showers/cryotherapy): Boosts norepinephrine/dopamine by 200–300%.
  • Intermittent Fasting: Promotes autophagy (cellular cleanup) and ketosis for brain repair.
  • Transcranial Magnetic Stimulation (TMS): Non-invasive stimulation of prefrontal cortex to restore motivation.
  • Cognitive Remediation: Puzzles, reading, or structured therapy to "retrain" frontal cortex function.
  • Mechanism: Acts as a mild SSRI/MAO inhibitor but interacts with many drugs (e.g., reduces antipsychotic efficacy).
  • Risk: Serotonin syndrome if combined with SSRIs. Safer alternatives: L-tryptophan, omega-3s, or adaptogens.

  • Gradual Tapering: Essential to avoid rebound psychosis. Work with a psychiatrist for dose reduction.
  • Avoid Dopamine Overstimulation: High-dose tyrosine/mucuna may trigger anxiety/psychosis in sensitive individuals.
  • Frontal Cortex Focus: Combine aerobic exercise, mindfulness, and cognitive challenges to rebuild executive function.
  • Timeline: Recovery may take 6+ months due to the drug’s long half-life. Synergistic strategies (e.g., NAC + exercise + omega-3s) are ideal.

  • Walking: Users report improved mood and cognition during early withdrawal, likely due to BDNF release.
  • Meditation/Mindfulness: Reduces stress-induced cortisol, supporting neuroplasticity.

Recovery from Invega/Xeplion’s effects requires a multi-pronged approach: repairing dopamine/serotonin pathways, reducing neuroinflammation, and stimulating neuroplasticity. Prioritize dietary supplements (tyrosine, NAC, omega-3s), lifestyle changes (exercise, fasting), and innovative therapies (TMS, cold exposure) while avoiding risky interactions (e.g., St. John’s Wort). Always collaborate with a healthcare provider experienced in antipsychotic withdrawal to tailor strategies safely.

Key Takeaway: While no single remedy guarantees rapid recovery, combining these approaches may accelerate the brain’s return to baseline function, particularly in the frontal cortex.

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very big guy​

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Today at 11:03 PM
Gradual Tapering: Essential to avoid rebound psychosis. Work with a psychiatrist for dose reduction.
Complete bullshit though it's impossible to get psychosis again when your brain is already nuked by the insane half life of the drug.

  • Mechanism: Acts as a mild SSRI/MAO inhibitor but interacts with many drugs (e.g., reduces antipsychotic efficacy).
That's actually the exact effect we want, so honestly I'd recommend it reading this, even though I can't confirm it really worked. Though I just had one bottle.

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very big guy​

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Today at 11:08 PM
Here's another one purely from deepseek. Chinese AI clearly less filtered/censored

Paliperidone primarily blocks dopamine D2 and serotonin 5-HT2A receptors. Long-term use, especially via injections (half-life: 25–49 days), can lead to:

  1. Dopamine receptor supersensitivity: Chronic blockade may cause upregulation of D2 receptors, contributing to withdrawal symptoms like agitation or psychosis.
  2. Frontal cortex dysfunction: Reduced dopamine and serotonin signaling in this region impairs executive function, motivation, and emotional regulation.
  3. Glutamate/GABA imbalance: Indirect effects on NMDA/glutamate pathways may worsen cognitive blunting.
  4. Neuroplasticity deficits: Long-term receptor blockade may reduce BDNF (brain-derived neurotrophic factor), critical for synaptic repair.
These changes explain symptoms like emotional numbness, loss of inner monologue, and catatonia.


  • L-Tyrosine: A dopamine precursor. Dose: 500–2000 mg/day. Supports natural dopamine synthesis, countering D2 receptor blockade.
  • Mucuna Pruriens (Velvet Bean): Contains L-DOPA, directly boosting dopamine. Dose: 100–300 mg standardized extract.
    → Caution: Start low to avoid overstimulation (risk of anxiety or psychosis in sensitive individuals).
  • St. John’s Wort: Acts as a mild SSRI and MAO inhibitor. May help restore serotonin balance post-5-HT2A blockade.
    → Dose: 300–600 mg standardized extract (0.3% hypericin).
    → Risks: Serotonin syndrome if combined with SSRIs; reduces efficacy of other drugs (e.g., birth control).
  • Omega-3 Fatty Acids (EPA/DHA): Reduce neuroinflammation and support BDNF. Dose: 1–2 g/day.
  • N-Acetylcysteine (NAC): Restores glutathione (antioxidant) and modulates glutamate. Dose: 600–1200 mg twice daily.
  • Lion’s Mane Mushroom: Stimulates nerve growth factor (NGF). Dose: 1–3 g/day.
  • Magnesium L-Threonate: Crosses the blood-brain barrier, calming NMDA hyperactivity. Dose: 144 mg elemental magnesium/day.
  • Taurine: Enhances GABA signaling. Dose: 1–3 g/day.
  • Coenzyme Q10: Improves cellular energy production. Dose: 100–300 mg/day.
  • B-Complex Vitamins: Critical for dopamine synthesis (B6, B9, B12).
  • Probiotics: Strains like Lactobacillus rhamnosus increase GABA and dopamine.
  • Vitamin D3: Low levels correlate with depression; supports serotonin synthesis. Dose: 2000–5000 IU/day.
  • Aerobic Exercise: Increases BDNF and dopamine receptor sensitivity. Even walking 30 mins/day helps.
  • Intermittent Fasting: Promotes autophagy (cellular cleanup) and ketosis, which may repair dopamine pathways.
  • Transcranial Magnetic Stimulation (TMS): Non-invasive brain stimulation targeting the prefrontal cortex.

  • Amantadine: NMDA antagonist and dopamine agonist. Used off-label for antipsychotic-induced apathy.
  • Agomelatine: Melatonin agonist + 5-HT2C antagonist. Improves sleep and mood without serotonin risks.
  • Microdosing Psilocybin: Anecdotal reports suggest it restores emotional depth and creativity by modulating 5-HT2A receptors. Caution: Legal risks and lack of clinical data.
  • Cold showers or cryotherapy boost norepinephrine and dopamine by 200–300%, potentially countering emotional blunting.

  • The injection’s 6-month washout period means recovery is gradual. Combining strategies (e.g., exercise + NAC + tyrosine) may synergize.
  • EEG Neurofeedback: Targets frontal cortex activity to restore cognitive flexibility.

  • St. John’s Wort: Avoid with SSRIs, antipsychotics, or birth control.
  • Dopamine agonists: Risk of mania/psychosis in predisposed individuals.
  • Gradual tapering: Essential to avoid rebound psychosis. Work with a psychiatrist open to integrative approaches.
 
Isn't it a shame, that us humans should have already figured this out (us doctors, scientists, psychiatrists) at least been researching this and put it together. But here with AI, just a prompt and we have all this. Perhaps you were the first person to ask it.
 
Psychiatry is like taking a fist full of darts and throwing them at the target. You get a bulls eye but somebody also loses theirs.
 
I'd like to also add that invega also partially blocks D3 and D4 receptors. It seems that the d2 receptors are more involved with cognition and the other two emotions, motivation, and reward.
 
invega011024 said:
Is there a sticky or a wiki for recovery information? ALSO CAN ANYONE ELSE NOT EXERCISE?

I am new here. I got a 150mg shot January 2025. I have intense anhedonia. It seems like people say 1 year for a 50% recovery. I would appreciate help. Thanks.

Also, has St John's Wort been investigated? Doesn't it take away the drug faster?
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Welcome to the club. You poor bustard. Just know the anhedonia gradually gets better.

What are you doing with your time?
 
invega011024 said:
It's unfortunate but there are so many variables and each person is different. I have been reading here and /r/antipsych obsessively.
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Get off of r/antipsych, not all of the information there is straight and it's going to give you more distress. You're going to be fine, just be patient.
 
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