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☮ Social ☮ PD Social Tripping Thread: aLL aBoArD tHe MoThErShiP 👽🛸

Actually the only other person that confirmed that mulungu is good for sleep is @emkee_reinvented. I am sure it will become more popular. It is not valerian. I mean you can feel valerian but it is herbal still. Mulungu feels like a drug to me.
Well NCBI also has a lot of article's about it. And native use confirms this. sleep, mood, anti-anxiety, anti-oxidant and stops seizure's Superiour to Diazepam.

And it's indeed not crap like Valerian, but it never felt like a drug to me. Even Melatonine due to the lucid dreaming was more psychoactive.

But you actually feel Valerian, or witnessing placebo. So what does it feel like? Ime its worthless and does nothing.
Pure Valerenic Acid though ( never tried ) might be nice. The extracts contain hardly any.
 
I've got some glaucine on the way. :cheer:

The blue lotus trip convinced me. I've always been on the fence about whether or not it actually sounded desirable based on the reports, but given that it's so close structurally to nuciferine and I now feel like I can understand the functional relationship between them too, it seemed worth exploring. I'll report back when I actually get around to trying it of course. Unsure how soon it will be, but probably not too long after I actually have it.
 
WHERE THE FUCK IS @Xorkoth ????

I would like to know that as well. I saw he had been away for a while recently and thought he might have just needed a break or went on vacation or something. Hopefully it’s just something like that…. There are other BLers who know him in person who I imagine would have said something by now if something happened.
 
Something else I think you may not have seen is that earlier this year, a user created a thread in this subforum claiming to be using psychedelics as a way of combating her terminal illness which she did not explicitly name, but said that it was related to inflammation.

[...]

In any case, like you, she did seem to report that the psychedelics really did help her symptoms and she did seem convinced that there was an inflammation-related reason. Again I hope that scientists will continue to pursue this avenue of research, because if psychedelics really can help with these kinds of conditions, then we need to be using them for it like yesterday.

Thank you again. I can't even imagine what she was going through between her disease, her paranoia of using illegal and taboo substances, and the burden of taking multiple heavy trips per week. I think multiple 5g+ mushroom trips per week is much even for a highly experienced tripper. The exception might be a "professional shaman", but this person is working in a highly ritualized fashion and likely underwent years of supervised training to develop the skill.

As for scientific progress, my general view is that the interesting and hard part about doing good science is coming up with good hypotheses to test, and this is something that contemporary scientists are not very good at and (due to competitive social pressures) getting worse all the time. What *will* make this kind of progress is informal work done to discover how to use these things effectively in such a way that there is a high likelihood of success in a clinical trial setting. A good model of this is psychedelic treatment of cluster migraines, which was reported anecdotally by many users and led to successful human trials. I don't know if this will lead to some kind of FDA approval any time soon though, but once psychedelics are FDA approved for other things, physicians can at least prescribe them "off-label". (Hopefully this will be the case with legal psychedelics.)

Sure, I'd love to see some kind of comprehensive survey of 5ht2a pharmacology in both the brain and "peripheral" body, but this will require a lot of human research including with a much wider variety of compounds than is being done (at any scale) today. While I'm impressed by what e,g, MAPS has accomplished given where we started, they are still (necessarily) narrowly focused on legitimizing their use in medicine, which means focusing on a narrow set of substances for a narrow set of conditions.

Meanwhile, I recently noticed that indigenous and contemporary "curanderos" are using psychedelics to treat various inflammatory conditions and have been doing so for centuries at least. On first pass, it's easy for people like us to take this for granted. The "Western" view of psychedelic shamanic healing is that it's mostly a mind thing. Some have "conceded" that "the purge may help rid the body of parasites" (a hypothesis I don't really buy), but for the most part, attention is focused on action in the brain. However, if one actually goes looking for all the 5ht2a receptors, one finds them all over the body including in many cells that are key to regulating inflammation and tissue healing. Activity in this regard between different psychedelic compounds may be quite diverse, but not much is known. This now seems like a serious omission!
 
But phenethylamines don't usually give me the same sort of feeling that tryptamines do where it sort of feels like the trip is still sort of spinning out of my mind in waves over the next few days on and off [...]

Wait, you don't get that for phenethylamines too? I do, and I'd say it's at least as pronounced with phenethylamines as tryptamines. Each different chemical leaves behind part of its spirit.

I do get that as well, the fatigue is only there while coming up but most psychedelics feel very clean and smooth and wonderful for me in the later hours and even leave me feeling that way for days afterward to some extent.

See my first query. You're saying you get "clean, smooth and wonderful" after effects from most psychedelics, but you only get "the trip is still sort of spinning out of my mind in waves" from tryptamines not phenethylamines? Thanks for the clarification.

I should say that while I say I get it worse with phenethylamines, it's really mostly the amphetamines I think that are biasing my perspective on that.

[...]

I think it might be a combination of the fact that they produce heavier effects for me in this way and also take several hours to peak, which can add up for me.

I guess a lot of reason I prefer phenethylamines to tryptamines is that I feel like the duration of negative effects is similar either way, but since phenethylamines tend to peak later, I'm more likely to be over the icky stuff before I peak instead of only feeling better after.

I'll have to get back to you after I try some amphetamine psychedelics though. So far all I've had is test dose of DOC, 0.25 mg I think, and that was long time ago.

The problem you mentioned with mushrooms is something that applies to 4-substituted tryptamines in general for me mostly, although mostly just them.

Actually the worst psychedelic for me was oral 5-Meo-DMT. With ayahuasca, I swallowed a capsule containing 5-ish mg, and I felt like I was in a physical crisis that lasted for something like 6 hours. I was shaking intensely and constantly. I cycled rapidly between feelings of intense heat and cold. I felt extremely light-headed and didn't dare try to stand up. Through all this, there were no visuals at all. The only notable mental effect was the malaise from the physical experience. I doubt I will ever experiment with 5-Meo-DMT again and probably won't touch 5-Meo- or 5-HO- anything altogether because I have a feeling my body chemistry is not compatible with those.

I can tolerate mushrooms as long as I am able to lie down for the first few hours, but this constrains my tripping activities considerably. I've tried a number of other tryptamines, and excepting the 5-Meo-DMT did not have these body issues. My favorite was probably 4-Aco-MIPT because it was a full, colorful trip like mushrooms but without the body issues. It felt to me a lot like how most other people described mushrooms, though I'm sure there are differences.

For what it's worth, base tryptamines for me are actually the easiest psychedelics to just sit there through, and not because they immobilize you despite making you want to move, but because they actually make you kind of not want to move despite not being that disorienting, or at least that's my experience with them. I feel like most of them keep the element that makes DMT trips make you just sit down and take it, even when taken orally and lasting for several hours.

Speaking only in terms of mushrooms vs. oral DMT, which were the two things I did almost exclusively for a few years, I'd have to say that I preferred mushrooms at lower doses and DMT for higher doses. First of all, using oral DMT I struggled with inconsistency between sessions, and so I basically had to always be prepared for a very intense trip. Hence, if I wanted a mild trip, mushrooms were the choice. On the flip-side, I felt the high dose DMT journey to be superior. It felt like I was literally plugged in with the cosmos, completely unlike anything else of this world, and as long as the dose was reasonable it was mercifully short.

I should note that even when the oral DMT fizzled, the ayahuasca alone was quite nice, and I'm quite certain that aya contributes quite a lot to the quality of the oral DMT taken with it. If taken in higher doses, aya alone can induce a dream-like visionary state, which is distinctly different from psychedelics. In fact, I don't know what to compare it to. I also combined aya a few times with a particular mescaline cactus that doesn't have much "extra stuff" like tyramine and was surprised that I experienced little potentiation, but at the low doses I had, it felt deeply healing and spiritual like nothing else. Too bad I have no idea where to get more of that cactus, and I'm guessing I won't get the same response to the standard varities which have a lot of stuff that look sketchy with MAOI.

I feel like I don't have many memories of dancing on base tryptamines that immediately come to mind, although it is also one of my core favorite activities to do on psychedelics in general usually (and I probably have done it plenty on base tryptamines too, but it's just not the kind of thing that stands out in my memory about them). Just some food for thought and advice, I suppose. This may be a just me thing, but I think if I had to choose a kind of psychedelic trip to have where I wanted to be able to not move that much and not feel like I'm suffering for doing do, I think there's a high chance I'd choose to take a base tryptamine.

The only other "base" tryptamine I had was DIPT, and I rather of liked DIPT. Ignoring the audio effects, I experienced wonderful heart opening effects together with a very relaxed feeling. I'd also be interested in studying the audio effects alone. I am curious about DPT, but I'm afraid of it too. There's also the ROA question. I lean toward rectal, but it doesn't seem to have any advocates. Lastly, I haven't had DMT on its own and am curious about smoked and more so rectal. I'd love to be able to reliably get to a nice medium level again and be able to stay there for a while.
 
I don't know how it would be in whatever country you would have to go to, but that's the kind of situation I'm in right now since I don't have my old stash anymore.

[...]

Eventually I think I'll get around to trying some of those other essential oils that contain phenethylamine-like compounds in them to see if they have notable effects in this way too.

I can't personally recommend messing around with essential oils, not because I have first-hand experience, but because I understand that most of these things are quite toxic in various ways in the amounts one likely needs to experience interesting effects. Seriously, when it comes to stuff like liver toxicity, you often don't know you've screwed up until it's too late. Proceed with extreme care if at all!

I'm not really rushing out to try to trip on a serotonergic psychedelic right now, though. I've just been thinking this way lately to make sure I'm aware of my options in case I do feel like I need them at any moment. Psychedelics are all around us even if the options aren't as luxurious as having a fat research chemical stash.

Given the current situation, I'd suggest sticking to the classic plants/fungi.

I'm also hoping psilocybin legalization is going to explode in this country soon like cannabis legaliztion and ketamine clinics have, fingers crossed. 🤞 That sure would be convenient.

[...]

Again though, where I find myself now, I could definitely see mescaline coming into clearer focus for me finally. It's one of the only drugs I haven't taken that I still have a very high interest in obtaining and experiencing at some point, and I genuinely don't have much else to use instead now (at least compared to what I'm used to).

I think for now decriminalization is much more interesting than legalization. What legalization means is that a doctor can prescribe someone one or more treatments at a licensed center, which are likely to cost $2000/each or something like that for psilocybin. Legalization has a ways to go still. MDMA is not yet legalized but this will probably happen (in applicable states) late in 2024 I think. I'm guessing it'll be a while longer before psilocybin gets an FDA approval, but I don't know. In the meantime, the same CO law which decriminalized plant psychedelics also legalizes psilocybin clinical treatments, but practically speaking, it's not legal until the Feds reschedule it because no commercial clinic is going to be able to operate until then.

In contrast, plant psychedelic decriminalization though means that consenting adults like us can legally share a plant sacrament or an extract of the same. Oregon has decriminalized psilocybin containing "plants". Colorado has decriminalized "plants" that contain psilocybin, DMT, mescaline, and ibogaine. This means that in Colorado today it's practically just as legal to trip on cacti with some friends as it is to smoke weed. Of course one can just walk into a store and buy weed; whereas I don't believe cactus can be legally be bought or sold "for human consumption", but as long as we don't talk about our sources, we can trip on cacti legally in Colorado under Colorado state law.

To your concerns about dosage, I believe mesacline is worthwhile at all doses. I'm not sure if my heaviest dose was consistent with what you may be looking for, but it was pretty powerful. I took it in the mountains at an outdoor camping event. The body effects were flooring, and I had intense visuals involving everything with eyes open. My ego regressed back to that of an innocent young child version of me but with all my adult facilities intact. In the peak, my partner and I wandered the area and socialized with an older couple, at least one of whom was apparently coming up on some acid. They expressed concern for our condition because we were walking very strangely. I demonstrated calmy, lucidly, and confidently that we were completely safe, prepared, in an excellent mind space, and that walking "like that" was actually a whole lot of fun. (And it was!) They seemed very surprised by my apparent collectedness, even as we were obviously blasted, and that is of course a distingushing feature of mescaline, from the other classics at least. Also, that trip lasted about 16 hours vs. the usual 12. It was a doozy!

I hope you are lucky enough to find some more as well. There's little better than reuniting with one of your favorite drugs after being away from it for so long.

(I know how it sounds and I don't care about social stigmas, it's the truth.)

I'm pretty sure I will be quite lucky in the near future. :)

About cannabis edibles and tripping, avoiding overdose is key. I also suggest straggered dosing. For example, a great psytrance event combo was to eat some weed food just as the LSD was starting to decline. The cannabis helped extend the LSD effects including relief from fatigue while transitioning into a relaxed and mellow state. It just smoothed out the whole come-down, and made sleep easy and very restorative when the time came.

Thanks for the responses, I hope your week has been going well. :)

Last week was pretty good but not really symptom free. Either 10 mg is too much 2C-I or I got triggered, either by something environmental or by my stress over my family issues. On Thursday, I had an excellent 20 mg 2C-D trip alone, which seemed to leave me in a better condition than the 10 mg 2C-I. This was followed by a couple highly euphoric "smart" days, one day of stressful family encounter, and then a few more days of diminishing euphoria and increasing tiredness. I'm feeling good now, 8 days later, and am contemplating what my next experiment should be.
 
5-HT2A receptors are fascinating. Did you know they are constitutively active,

[...]

I like to think of it as 3D shapes bouncing around. The 5-HT2A receptor itself is a construct that signals in certain ways based on its 3D shape, and is already doing so by default. And when a ligand comes along, binding to the receptor, it changes that 3D shape into something that signals in a different way from what the original shape did. That's literally how I tend to actually visualize it anyway.

Your visualization is a good start. Other things to consider are elecrical attractions and repulsions. Different parts of the ligand and/or receptor tend to have a positive or negative electrical charge. Opposite charges attract while similar repell. There are also some milder effects which can cause attraction or repulsion. Different ligands can have different effects on the receptor shape.

The receptor itself is usually attached to a complex, and may be coupled with receptors of similar or different type (like CB1). The 5ht2a receptor can be attached to many different possible complexes, which can also effect the shapes taken by receptors when they bind to ligands and the resulting effects.

As noted in that article, multiple effects are possible via the same 5ht2a. Trivially, it is observed that most 5ht2a antagonists cause receptor down-regulation just as agonists do, which suggests that downregulation can be considered an independent effect from whatever serotonin is doing. This is important being that downregulation may persist for quite a long time and be important to many desired effects of psychdelics during and long after the chemical is still present. Additionally, serotonin is known to act on at least three independent effect pathways, each of which can be differentially activitated by different chemicals.

Let me quote from another source which gets into the details of just how insanely complex this is:

Stimulation of the 5-HT2A receptor leads to the production of at least three distinct biochemical signals, IP3/diacylglycerol, arachidonic acid (AA), 2-arachidonylglycerol (2-AG), and the relative activation of these pathways varies with the ligand used [68]. By measuring simultaneously at least two of these pathways using radioactively labeled IP3 and arachidonic acid (the signal transduction outputs of each of these pathways from the same cells) it has been seen that ligands vary in the efficacy with which they stimulate each of the different pathways.

More recently, identification of molecular players involved in the signaling cascade resulting in 5-HT2A receptor-induced arachidonic acid release, revealed that more than one signaling pathway is involved [69]. It raises the possibility that using a single readout such as arachidonic acid to characterize a biochemical pathway may not be sufficient. Different ligands may activate different pathways that finally impinge on the same molecule.

Numerous studies in different cell lines using antibodies to look at levels of molecular players have linked regulation of several signaling pathways to the 5-HT2A receptor. In addition to the three major pathways mentioned above, 5-HT2A stimulation can lead to a change in levels and/or activity of several molecular players including PLA2, PLD, ERK1/2, nitric oxide, calmodulin, CREB, Akt, Fos, TGF-β, EGFR, and JAK/STATs [39,70–79], depending on cell line used and the context of stimulation. Some, if not all, of these pathways will undoubtedly be involved in functional selectivity displayed by ligands targeting the receptor. This leads to a situation of ever-increasing complexity wherein accurate characterization of receptor signaling will require simultaneous measurements of a number of key molecular players involved in each of these pathways.

In addition to these signaling pathways, receptor regulation also takes another form, i.e., internalization and recycling of the receptor. Interestingly, this pathway, too, is differentially regulated by different ligands.

Mind you, all this talk is still looking at things with a view of "the trees" rather than "the forest". The body is system with many complicated feedback loops. Here, we better consider "non-selective" effects as well including a potentially wide array of effects at alpha-1 for phenethylamines and all the crazy stuff LSD does. I think a great many of the interesting effects of psychedelics arise from the downstream cascade of effects (think falling dominos), which persist long after the drug is gone.

The rabbit hole goes very deep indeed!
 
Thank you again. I can't even imagine what she was going through between her disease, her paranoia of using illegal and taboo substances, and the burden of taking multiple heavy trips per week. I think multiple 5g+ mushroom trips per week is much even for a highly experienced tripper. The exception might be a "professional shaman", but this person is working in a highly ritualized fashion and likely underwent years of supervised training to develop the skill.

No problem. And yeah, that much tripping on that much mushrooms is... a lot. Ironically, I actually recommended to her that she try using mescaline instead, heh. Even not having used it myself, I figured that from everything I'd heard about it, it'd probably be a lot easier to take multiple times a week than a heavy dosage of mushrooms, and thought that maybe the duration being like twice as long might cut down on the number of trips she'd have to have to sustain the same amount of anti-inflammatory effect or something. She was interested in it, but hadn't tried it yet by the last message she sent me, so I don't know if she ever did try it.

As for scientific progress, my general view is that the interesting and hard part about doing good science is coming up with good hypotheses to test, and this is something that contemporary scientists are not very good at and (due to competitive social pressures) getting worse all the time. What *will* make this kind of progress is informal work done to discover how to use these things effectively in such a way that there is a high likelihood of success in a clinical trial setting. A good model of this is psychedelic treatment of cluster migraines, which was reported anecdotally by many users and led to successful human trials. I don't know if this will lead to some kind of FDA approval any time soon though, but once psychedelics are FDA approved for other things, physicians can at least prescribe them "off-label". (Hopefully this will be the case with legal psychedelics.)

Sure, I'd love to see some kind of comprehensive survey of 5ht2a pharmacology in both the brain and "peripheral" body, but this will require a lot of human research including with a much wider variety of compounds than is being done (at any scale) today. While I'm impressed by what e,g, MAPS has accomplished given where we started, they are still (necessarily) narrowly focused on legitimizing their use in medicine, which means focusing on a narrow set of substances for a narrow set of conditions.

I agree with what you're saying, but it's still annoying that they would have already figured out the right way to do it a long time ago if the research hadn't been illegalized in the first place. We're only playing catch-up and having to try it ourselves now because the people in charge didn't trust us to do it before. Well, that's not really why psychedelics are illegal, but... I'm sure you get what I'm saying.

Meanwhile, I recently noticed that indigenous and contemporary "curanderos" are using psychedelics to treat various inflammatory conditions and have been doing so for centuries at least. On first pass, it's easy for people like us to take this for granted. The "Western" view of psychedelic shamanic healing is that it's mostly a mind thing. Some have "conceded" that "the purge may help rid the body of parasites" (a hypothesis I don't really buy), but for the most part, attention is focused on action in the brain. However, if one actually goes looking for all the 5ht2a receptors, one finds them all over the body including in many cells that are key to regulating inflammation and tissue healing. Activity in this regard between different psychedelic compounds may be quite diverse, but not much is known. This now seems like a serious omission!

Personally, I've always thought of psychedelics as working on both the brain and the body. I've getting physiological benefits from drugs from the very beginning of my use of them, though. When I first started using cannabis in high school, for instance, I was overweight to the point that my doctors told me I was at risk of getting diabetes and actually had some physical signs of starting to develop it. Then, I started smoking cannabis, and by the end of the year, I lost a ton of weight despite not changing a single thing about my exercise routine (or lack thereof) and actually eating more junk food after starting to smoke than I had beforehand. My physical signs of developing diabetes disappeared and no doctor ever brought it up to me again. (I still worry about it coming back, though.)

Nowadays, there is actually a growing body of scientific research validating the observation that people who use cannabis regularly actually seem to both consume a greater number of calories and have a lower BMI on average than people who don't, and showing that this superficially paradoxical relationship likely has to do with the way that THC interacts with and regulates cannabinoid receptors in the body, which on their own when activated by endogenous full agonists actually appear to be directly involved in high fat diet-induced weight gain and the development of conditions like diabetes, whereas THC can functionally antagonize their activity when it's at high endogenous levels by being a partial agonist on top of downregulating the receptors with frequent use. As far as I'm concerned cannabis may very well have essentially saved my life for entirely physical reasons even while allowing me to literally enjoy my life even more cognitively than I had been before using it. It's one of the reasons I hold it in such high regard.

I also think it may be meaningful to consider that the "mind" is just coming from the brain which is still just a part of the body. Like, I think it's not unlikely that even a lot of the psychological conditions psychedelics help with really probably just relate to something like them reducing inflammation in the brain. There are some ways that psychedelics seem to help me cognitively that seem purely mechanical, not related to the trip I actually had on them or anything, that I could easily see having that kind of explanation for how they work. I hope more people continue to see drugs are being useful in these ways too, because that's basically how I've treated them since I started out and I have to say I'm pretty happy with the results so far, and wish other people could share in that success too.
 
Wait, you don't get that for phenethylamines too? I do, and I'd say it's at least as pronounced with phenethylamines as tryptamines. Each different chemical leaves behind part of its spirit.

...

See my first query. You're saying you get "clean, smooth and wonderful" after effects from most psychedelics, but you only get "the trip is still sort of spinning out of my mind in waves" from tryptamines not phenethylamines? Thanks for the clarification.

Those are completely different things that I'm referring to, although I can understand conflating them from an outside perspective. The "clean and smooth and wonderful" feeling to me is just a feeling like I still feel physically healed after having had a trip, like I feel younger and more physically disinhibited again, and I have less pain and lethargy and such. It doesn't feel to me like I'm actually still tripping on anything, just like I'm still benefiting from having tripped.

The "spinning out of my mind in waves" that I describe from tryptamines literally does feel like I'm still tripping mentally for the next few days, and it doesn't have anything to do with feeling fresh and healed or anything. It feels inebriating to the point that sometimes I worry about my ability to do things that require me to be sober for the next few days still. It basically just feels like the cognitive effects of the drug outlive the immediate effects of the chemical actually being in my brain, and I still have to make my way down through them at the pace that they work at, whatever they may be. I do tend to find that this is common for me with tryptamines and uncommon for me with phenethylamines. On the other hand, I tend to feel refreshed after trips in the physical way from most psychedelics as I recall.

I guess a lot of reason I prefer phenethylamines to tryptamines is that I feel like the duration of negative effects is similar either way, but since phenethylamines tend to peak later, I'm more likely to be over the icky stuff before I peak instead of only feeling better after.

I'll have to get back to you after I try some amphetamine psychedelics though. So far all I've had is test dose of DOC, 0.25 mg I think, and that was long time ago.

That's interesting. I personally feel like all psychedelics feel pretty much fine by what I would consider the peak, and potentially weird up to that point. It doesn't really affect my preference for them much anymore. I just expect it and still know I'm going to get something out of the trip anyway.

Actually the worst psychedelic for me was oral 5-Meo-DMT. With ayahuasca, I swallowed a capsule containing 5-ish mg, and I felt like I was in a physical crisis that lasted for something like 6 hours. I was shaking intensely and constantly. I cycled rapidly between feelings of intense heat and cold. I felt extremely light-headed and didn't dare try to stand up. Through all this, there were no visuals at all. The only notable mental effect was the malaise from the physical experience. I doubt I will ever experiment with 5-Meo-DMT again and probably won't touch 5-Meo- or 5-HO- anything altogether because I have a feeling my body chemistry is not compatible with those.

For what it's worth, that makes total sense to me, but I feel like there's a chance you're letting that experience cloud the picture of what 5-MeO-DMT is really like more generally, and I say that without even having tried 5-MeO-DMT yet myself.

There's a couple quick reasons I have to give for this.... The first is that I've actually seen scientific research that explicitly suggested that 5-MeO-DMT metabolizes into 5-HO-DMT/bufotenine when taken orally, and that taking 5-MeO-DMT with a MAOI also increases the amount of bufotenine that is formed and that remains in your system. From what I'm aware, bufotenine is a completely miserable substance to take orally, seeming to get entirely clogged up in the body and often producing just tons of uncomfortable physical side effects and usually little to no trip. Even when smoking bufotenine, I personally found it to be unusually body-heavy, compared to literally basically any other psychedelic I've ever tried. From what I can tell, I'm not the only person to think this way.

And second, I've used 5-MeO-MiPT, 5-MeO-EiPT, and 5-MeO-DiPT both orally and by smoking, and even without a MAOI, they all have noticeable body loads for me when taken orally, but not when smoking them. 5-MeO-MiPT's is the mildest for me, only sometimes being kind of bad, but still worse than other kinds of tryptamines; I could imagine that this is why it's often said to be the most popular one. 5-MeO-DiPT's body load to me is pretty bad, the only thing that really makes it worth it is that the trips are also really interesting to me, and even then, I tend to find myself mostly just wishing it would go away by the end of it. 5-MeO-EiPT I only took once and it was literally crippling to the point that it felt unsafe (which I'm not saying it was, that's just how bad it felt) and I have no desire to ever experience that again, even though I wish I could take it orally without that still. By contrast, none of them has had any notable body load for me when smoked, except for, ironically, one time on 5-MeO-MiPT, but it was still really light. I actually find them to be extremely smooth when smoked, more so than most other psychedelics when taken orally.

As I said I haven't actually taken 5-MeO-DMT myself yet, but I have a feeling this might be why it is usually smoked or snorted, on top of the fact that having it come on hard and fast supposedly just also helps you get more out of it in the way it's popularly known for being unique. That's definitely what I would do personally, smoke it, not take it orally except maybe down the line if I've just already smoked it a lot and want to try it for comparison reasons or something. So, this seemed worth saying to me. The way you used it is what I personally would suspect the way to be by far the most likely to induce the kind of physically uncomfortable and low intensity experience that you had with it.

I can tolerate mushrooms as long as I am able to lie down for the first few hours, but this constrains my tripping activities considerably. I've tried a number of other tryptamines, and excepting the 5-Meo-DMT did not have these body issues. My favorite was probably 4-Aco-MIPT because it was a full, colorful trip like mushrooms but without the body issues. It felt to me a lot like how most other people described mushrooms, though I'm sure there are differences.

I haven't used 4-AcO-MiPT, but I have used 4-HO-MiPT plenty. I like it. It's not my favorite or the most impressive of the tryptamines for me, but it's probably generally the 4-substituted tryptamine I'd be most likely to take recreationally. It does have some notable similarities to mushrooms for me, but I find it to be more ornate, digital, and sexy. For years now I've described it as having a "burlesque" vibe. Fun stuff. Sometimes weird though too....

Speaking only in terms of mushrooms vs. oral DMT, which were the two things I did almost exclusively for a few years, I'd have to say that I preferred mushrooms at lower doses and DMT for higher doses. First of all, using oral DMT I struggled with inconsistency between sessions, and so I basically had to always be prepared for a very intense trip. Hence, if I wanted a mild trip, mushrooms were the choice. On the flip-side, I felt the high dose DMT journey to be superior. It felt like I was literally plugged in with the cosmos, completely unlike anything else of this world, and as long as the dose was reasonable it was mercifully short.

I still haven't taken oral DMT unfortunately, but I have used MPT, MiPT, DiPT, and MALT orally. I also agree that high dosages seem like the way to go with them. 100 mg of MPT and 50 mg of MiPT were some of my most memorable trips ever, not only for but in part for the hallucinogenic intensity. I feel I should note though that I have a reputation for getting effects from base tryptamines more easily than other people around here. I can be absolutely blown away by otherworldly hallucinations at a dosage where other people are like, "Yeah, this feels pretty nice I suppose." This seems to somewhat be the case with 5-methoxytryptamines for me too. I don't complain but I wish I had an explanation for why, I'd love it if more other people experienced them on the level I do too. I do know I'm not the only one to trip easily from them at least.

In my experience, what you said about DMT vs mushrooms holds up for base tryptamines vs 4-substituted tryptamines in general, on average at least. I find the former less interesting unless taken to the more DMT-like visionary/breakthrough point, in which case they really excel, whereas the latter I find to be more mental and about visual distortions that are less complex but already more active at lower dosages, and I find them to be more in line with the stereotypical idea of a psychedelic trip popularized by the likes of LSD for instance in general.

I should note that even when the oral DMT fizzled, the ayahuasca alone was quite nice, and I'm quite certain that aya contributes quite a lot to the quality of the oral DMT taken with it. If taken in higher doses, aya alone can induce a dream-like visionary state, which is distinctly different from psychedelics. In fact, I don't know what to compare it to. I also combined aya a few times with a particular mescaline cactus that doesn't have much "extra stuff" like tyramine and was surprised that I experienced little potentiation, but at the low doses I had, it felt deeply healing and spiritual like nothing else. Too bad I have no idea where to get more of that cactus, and I'm guessing I won't get the same response to the standard varities which have a lot of stuff that look sketchy with MAOI.

I really would like to try the harmala plants alone for this reason too. I've heard a lot about their visionary potential but never got around to trying them that way myself.

The only other "base" tryptamine I had was DIPT, and I rather of liked DIPT. Ignoring the audio effects, I experienced wonderful heart opening effects together with a very relaxed feeling. I'd also be interested in studying the audio effects alone. I am curious about DPT, but I'm afraid of it too. There's also the ROA question. I lean toward rectal, but it doesn't seem to have any advocates. Lastly, I haven't had DMT on its own and am curious about smoked and more so rectal. I'd love to be able to reliably get to a nice medium level again and be able to stay there for a while.

I really like DiPT too, and I'd really love it if I could have just the psychedelic trip without the unique auditory effects on top of it. Unfortunately, at any active dosage for the auditory effects for me, the way they make my ears feel is literally painful, causes a nonstop aggravating ringing, and it's so bad that I have spent an entire DiPT drinking alcohol just to distract myself from it. I wouldn't want to take this unique pharmacological tool and potential for learning away from the world of course, I just wish I could enjoy the trip without the literal pain and constant ringing. I did get to enjoy the auditory effects to at least some extent with hearing distorted voices and music and stuff once, but I think that was probably enough for me in that regard knowing how it's gone since then.

I've actually known a lot of people to praise rectal DPT, for what it's worth. I'm afraid I can't recall what they actually said about it though, I don't use drugs rectally and I don't really make an attempt to remember what other people said about it. I personally smoked it, and I had a great and extremely easygoing trip at 30 mg. I'll just throw out there that I think the people who were first trying and writing trip reports about DPT were waaaaay overshooting the dosage, and that a lot of its reputation for being so intense and heavy and dark probably mostly came from that. I do still find it to be one of the psychedelics that's on the "spookier" side even at lower dosages, but not in any intimidating or uncomfortable way; I actually smoked it to celebrate Halloween once and thought that it fit the mood quite well. I've known other people who were afraid of doing DPT as well and I just always have to put my opinion out there that I really don't think of it as much different from other tryptamines at large, I actually find it unusually calm and clean feeling for a tryptamine when the trip is good.

That being said, on the other end of things, I'm actually not much of a fan of smoking DMT, to a degree that seems like I like it less than most people I encounter. (So, maybe I'm just a weird one, really.) I cannot speak to taking it rectally, I've only smoked it and once done IM. (It was meh, I don't think I got a high enough dosage though.) For me smoked DMT usually has a lot more uncomfortable body feelings than most other psychedelics in general, similar to bufotenine although much less severely than that still. The trip also just doesn't really interest me most of the time, although I'd probably find it a lot more enjoyable if not for the body load, because then I could just be happy with it being what it is. As it is I hope for it to be worth the struggle and I usually just find it to go by too fast to really make much of. I haven't actually been able to "breakthrough" in the stereotypical way that people describe with smoking it though, despite many attempts. Maybe if I'm able to do that one day my opinion of it will change.

So yeah, you should probably keep in mind that as much experience with and opinions about tryptamines that I have, they may not generally apply to most people on average, lol.
 
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I can't personally recommend messing around with essential oils, not because I have first-hand experience, but because I understand that most of these things are quite toxic in various ways in the amounts one likely needs to experience interesting effects. Seriously, when it comes to stuff like liver toxicity, you often don't know you've screwed up until it's too late. Proceed with extreme care if at all!

I appreciate and understand your concern, but I'm really not too worried about using them in the way that I would use them.

This is my most circumstantial point, but I'll start off by saying it really does depend on the oil too. Nutmeg essential oil seems to largely consist of the active allylbenzenes (like myristicin) and a bunch of terpenes that are also found in cannabis. That doesn't particularly scare me. I'd still have to look more into the other oils though.

Additionally, I've known several people who already used these oils to trip on much more than I probably ever will, without any apparent problems resulting from it. I know that doesn't prove anything, but I really don't think I'd probably use them enough for it to matter unless they were so toxic that just a few times did real, lasting damage. I just don't have that much actual interest in using them, and even when I do use psychedelics, I tend to only use them a few times at most and then move on, most of the time anyway. I didn't actually intend to use psychedelics in this way - in fact, I could have saved a lot of money in building up that stash I no longer even have if I had known beforehand that it was going to turn out that way - but that is the way it turned out; it's very rare that a psychedelic just makes me want to keep taking it again and again and again, and even when I have sometimes felt that way, I've often found that just a small handful of trips turned out to be satisfying enough to change my mind down the road.

I realize that things would be different if I were using them to help with an ongoing physical illness and wanted to take them repeatedly for a long time, for instance. But that's not really what my relationship with psychedelics is, for the most part. Like I said I do feel like there's something more mechanical and predictable I get out of psychedelics that helps me too so it's not entirely just about each trip being unique or anything, but the latter is still mostly what they have been to me so far, something that once I experience them, I don't necessarily need to experience them again. So, I just am not too concerned about trying things like this a few times, and if I end up liking them more than that anyway, well, I've had to give up things that I like before and still been fine.

Nutmeg essential oil I think is actually one of the best psychedelics I ever took, in some ways at least. I'm really glad I pushed it to that point and still have the memory of it to live with. I do understand that their are potential risks to using them though, and I also point this out to others when discussing the possibility of using the oils with them. That's why I'm not going as far as some oilahuasca enthusiasts; I've known to take several different essential oils at once just trying to modulate their enzyme activities to get the most out of all the other oils simultaneously and stuff like that, and that seems a little too experimental to be worth risking for me.

Given the current situation, I'd suggest sticking to the classic plants/fungi.

Again, I appreciate the concern, but I think you may be underestimating how much I've thought these things through and have more than just preliminary knowledge about them. I've been a very experimental drug user for some time now.

I think it should be emphasized again how much I'm really not looking to trip right now anyway. My thoughts about these things is more of a knee-jerk reaction to the loss of my research chemical supply than anything. Even when I still had my stash, I hadn't been actively using anything from it for some time already. I don't really feel as though I still have a lot to get out of psychedelics anymore and haven't for a couple years now. I don't usually trip unless I have a specific intention in mind and I'm not even sure what my intentions would be anymore.

There is one exception, and that's that I would like to try smoking 5-MeO-DMT. For complex reasons that getting into now would take up a lot of effort unsolicited. But that's really all I've got on the horizon that I'm still genuinely hoping to seek out for another experience related to my journey of self discovery and such with psychedelics.

I do still want to try mescaline too, but that's mostly just because, you know, it's mescaline. I'm open to it being great but I don't really have any specific goals in mind with it or anything. In any case if I did want to keep using that one repeatedly too, I obviously wouldn't be afraid to do so anyway.

I think for now decriminalization is much more interesting than legalization. What legalization means is that a doctor can prescribe someone one or more treatments at a licensed center, which are likely to cost $2000/each or something like that for psilocybin. Legalization has a ways to go still. MDMA is not yet legalized but this will probably happen (in applicable states) late in 2024 I think. I'm guessing it'll be a while longer before psilocybin gets an FDA approval, but I don't know. In the meantime, the same CO law which decriminalized plant psychedelics also legalizes psilocybin clinical treatments, but practically speaking, it's not legal until the Feds reschedule it because no commercial clinic is going to be able to operate until then.

I mean, you could say the same thing about cannabis, but we still call it legalization. I was just using the term in that same sort of way.

In contrast, plant psychedelic decriminalization though means that consenting adults like us can legally share a plant sacrament or an extract of the same. Oregon has decriminalized psilocybin containing "plants". Colorado has decriminalized "plants" that contain psilocybin, DMT, mescaline, and ibogaine. This means that in Colorado today it's practically just as legal to trip on cacti with some friends as it is to smoke weed. Of course one can just walk into a store and buy weed; whereas I don't believe cactus can be legally be bought or sold "for human consumption", but as long as we don't talk about our sources, we can trip on cacti legally in Colorado under Colorado state law.

That just doesn't sound desirable compared to full legalization to me honestly. If I have to hide anything about it in any way, it's a problem in my eyes. But I also disagree with the notion that legalization means you'll only be able to buy it from a doctor for a huge price or something. Legalization does not in any way inherently mean that, we just have to do legalization the right way and not the way that makes it that way.

To your concerns about dosage, I believe mesacline is worthwhile at all doses. I'm not sure if my heaviest dose was consistent with what you may be looking for, but it was pretty powerful. I took it in the mountains at an outdoor camping event. The body effects were flooring, and I had intense visuals involving everything with eyes open. My ego regressed back to that of an innocent young child version of me but with all my adult facilities intact. In the peak, my partner and I wandered the area and socialized with an older couple, at least one of whom was apparently coming up on some acid. They expressed concern for our condition because we were walking very strangely. I demonstrated calmy, lucidly, and confidently that we were completely safe, prepared, in an excellent mind space, and that walking "like that" was actually a whole lot of fun. (And it was!) They seemed very surprised by my apparent collectedness, even as we were obviously blasted, and that is of course a distingushing feature of mescaline, from the other classics at least. Also, that trip lasted about 16 hours vs. the usual 12. It was a doozy!

I'm not saying I'm going to demand that it be blinding hallucinogenic or anything either, I'm just saying I'm not going to stop just because my first attempt might turn out to be weak and uncomfortable or something. I know enough about mescaline to know that if it's not that impressive, I just need to dose higher.

The way you described that mescaline experience actually reminds me a whole lot of my best experiences with 4-HO-MET and 4-AcO-MET. That's actually some pretty interesting perspective for me to consider.... I feel like that tells me a lot more about what I might expect from it than I've generally gotten from peoples' descriptions otherwise. I appreciate the anecdote.

I'm pretty sure I will be quite lucky in the near future. :)

Lucky. I hope it's a blast!

About cannabis edibles and tripping, avoiding overdose is key. I also suggest straggered dosing. For example, a great psytrance event combo was to eat some weed food just as the LSD was starting to decline. The cannabis helped extend the LSD effects including relief from fatigue while transitioning into a relaxed and mellow state. It just smoothed out the whole come-down, and made sleep easy and very restorative when the time came.

I appreciate the advice. I can see how that would go nicely with something like LSD in particular, and would be a little more comparable to the influence I'm used to getting from smoking cannabis during a LSD trip as well, which does sound nice.

Last week was pretty good but not really symptom free. Either 10 mg is too much 2C-I or I got triggered, either by something environmental or by my stress over my family issues. On Thursday, I had an excellent 20 mg 2C-D trip alone, which seemed to leave me in a better condition than the 10 mg 2C-I. This was followed by a couple highly euphoric "smart" days, one day of stressful family encounter, and then a few more days of diminishing euphoria and increasing tiredness. I'm feeling good now, 8 days later, and am contemplating what my next experiment should be.

I'm sorry to hear that, but I'm glad it got better afterward. I hope the next one is useful for you as well.
 
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Your visualization is a good start. Other things to consider are elecrical attractions and repulsions. Different parts of the ligand and/or receptor tend to have a positive or negative electrical charge. Opposite charges attract while similar repell. There are also some milder effects which can cause attraction or repulsion. Different ligands can have different effects on the receptor shape.

That is something I hadn't considered and is interesting to think about. I'll have to keep it in mind in the future.

The receptor itself is usually attached to a complex, and may be coupled with receptors of similar or different type (like CB1). The 5ht2a receptor can be attached to many different possible complexes, which can also effect the shapes taken by receptors when they bind to ligands and the resulting effects.

I am aware of this and think it's really cool. I know scientists right now seemed to be focused on the idea that the 5-HT2A-mGluR2 heterodimer might be the one "responsible for psychedelic effects" or whatever as they say, but I have to say, I'm incredibly suspicious about the 5-HT2A-CB1 heterodimer playing some critical role too given how psychedelic cannabinoids can be too. I have read a paper that said that both 5-HT2A and CB1 receptor agonists signal similarly through the heterodimer at least when applied separately (they interestingly have some antagonistic effects when applied simultaneously) so there is at least one clear plausible explanation for how 5-HT2A receptor agonists and CB1 receptors agonists could at least separately could affect the brain in the same sort of way as one another. I'm really not exaggerating when I say that a strong cannabis edible trip to me is a lot like a lysergamide.... If you gave me that first really good 50 mg oral trip I had and made it so I had no conception of what cannabis trips were like prior to that and didn't know that's what that was and you told me to guess, I think I'd almost certainly guess that it was a lysergamide of some kind that was given to me, with just the slightest suspicion of why it felt a little bit like cannabis.

I'm sure plenty of different receptor complexes contribute to what we think of as the totality of psychedelics personally, regardless of what the scientists think currently. At least, I'd bet on it.

As noted in that article, multiple effects are possible via the same 5ht2a. Trivially, it is observed that most 5ht2a antagonists cause receptor down-regulation just as agonists do, which suggests that downregulation can be considered an independent effect from whatever serotonin is doing. This is important being that downregulation may persist for quite a long time and be important to many desired effects of psychdelics during and long after the chemical is still present. Additionally, serotonin is known to act on at least three independent effect pathways, each of which can be differentially activitated by different chemicals.

Let me quote from another source which gets into the details of just how insanely complex this is:

[...]

This is the kind of stuff I spent most of my many years using psychedelics actively thinking about. I used to try to connect the specific subjective effects I got from each one to different functional activity and signaling pathways known and documented for all the different molecules I was using in different scientific studies, but I kind of grew out of it once I realized from going through enough different ideas and enough different research papers that it was just too complicated a picture that we had too little visibility of so far for me to truly satisfactorily figure out if meaningfully figure out at all in the way that I was hoping to. I felt that I was starting to hold back my conception of the drugs I was taking by trying them to fit them to the mold of my theories in my mind, so I decided to stop doing that (very explicitly) and start just paying more attention to the effects I get and comparing and contrasting the drugs more generally and stuff in those ways.

However, that's just me wanting to make sure I wasn't jumping to conclusions about my trips. I definitely understand the value in understanding pathways like this for the sake of making things like targeted medications. It is certainly extremely complex though. It's part of why I find the differences in each psychedelic so fascinating even when not discussing it specifically, I know there are more than just small differences amounting to those subjective distinctions.

Mind you, all this talk is still looking at things with a view of "the trees" rather than "the forest". The body is system with many complicated feedback loops. Here, we better consider "non-selective" effects as well including a potentially wide array of effects at alpha-1 for phenethylamines and all the crazy stuff LSD does. I think a great many of the interesting effects of psychedelics arise from the downstream cascade of effects (think falling dominos), which persist long after the drug is gone.

The rabbit hole goes very deep indeed!

That's the kind of thing I think is going on like with my tryptamine aftereffects for instance. Like, the psychedelic effects are not just a direct result of the chemical being in our brains, but are from some sort of process that gets triggered that takes however much time it takes to spiral out, regardless of if the drug is metabolized and/or excreted. I suppose the bodily healing aftereffects could be thought of as similar too, although I think I was tending to picture them as something more like a clearing out of knots in the system or something, so like the absence of problems is what's lasting more than the presence of a trip, I guess I would put it. (Although this is literally the first time I've tried to explain a difference between the two.)

Thanks for the responses again. :)
 
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Today, I had a 2 mg taste of 2C-B (HBr). It was very tasty indeed!

I only had 2C-B once before, 1.5 decades ago, at a lowish dose (12 mg?). I got hit rather hard by nausea and other body effects on the come-up followed by an experience that seemed rather weak (for the price paid) and which dropped off sooner than I could settle in to it.

This experience confirms my decision to re-evaluate. Whether the first time was a fluke or I maybe just need a lower dose than most people, this 2 mg experience points to something very special awaiting me at my higher dose trials. Indeed, of the 4 different 2C drugs that I've now tried at this very low dose level, I've enjoyed 2C-B the most. The difference with 2C-I is pretty marked. The 2C-B felt very gentle and relaxed compared to the intense push felt from 2C-I. With 2C-I, I felt a strong drive to be being engaged in some activity, but with 2C-B, I felt carefree and casual without being sedated. It felt wonderful, even heavenly to indulge in sensations of all kinds. I got some minor visuals which included some remarkable tactile/visual synaesthesia. When I was touched by another, colors would shoot off my body like curly fireworks, or the touches would conjure up other interesting imagery. I love synaesthesia. Actually, I think we're almost all synaesthetic even when sober, but most of us don't notice it because the different sensory inputs are fused into one perception before they bubble up to consciousness.

I should emphasize that these feelings were all (not quite subtle but) very mild at this dose, but qualitatively it was all there. I can only imagine what "turning it up" some more will do for me. I should find out what 4 mg is like in a few days.
 
No problem. And yeah, that much tripping on that much mushrooms is... a lot. Ironically, I actually recommended to her that she try using mescaline instead, heh.

I would have suggested mescaline as well. I have no idea how well it would have worked as compared, but I do think it's psychologically gentler even at strong doses. Of course it also lasts twice as long or longer with comparably heroic levels. Anyway, without the thread she deleted it's very hard to discuss specifics.

I agree with what you're saying, but it's still annoying that they would have already figured out the right way to do it a long time ago if the research hadn't been illegalized in the first place. We're only playing catch-up and having to try it ourselves now because the people in charge didn't trust us to do it before. Well, that's not really why psychedelics are illegal, but... I'm sure you get what I'm saying.

I disagree that these things would be "figured out" if not for prohibition. Don't get me wrong, prohibition is a terrible hindrance, but many other things come into play. The xenophobia against altered states of consciousness would still be there without prohibition, for example, but also the pharmacology is fundamentally difficult. There are insufficient resources (i.e. funds) to move this stuff forward faster, which is not just because of social taboo.

Look at what MAPS has done---and not done. Now, barring mismanagement of funds or other sort of dysfunction that I don't know about (which is all too common among NGOs these days), MAPS is pretty much doing as much as they can with the money they have. It's enough to get MDMA approved for PTSD, and maybe eventually psilocybin approved for depression, "treatment resistant" in both cases. This is a big deal and is leading to many exciting knock-on effects, but it's also minuscule relative to work required to really understand how these drugs actually work and what all they are actually capable of.

Of course some of this can perhaps be elucidated informally by people like us. This kind of data is anecdotal without some kind of experimental structure, but while anecdotal data tends to be unreliable, it may also be the best source of crucial insights, which can lead to formal experiments that are better designed and have a higher success rate.

Personally, I've always thought of psychedelics as working on both the brain and the body. I've getting physiological benefits from drugs from the very beginning of my use of them, though. When I first started using cannabis in high school, for instance, I was overweight to the point that my doctors told me I was at risk of getting diabetes and actually had some physical signs of starting to develop it. Then, I started smoking cannabis, and by the end of the year, I lost a ton of weight despite not changing a single thing about my exercise routine (or lack thereof) and actually eating more junk food after starting to smoke than I had beforehand. My physical signs of developing diabetes disappeared and no doctor ever brought it up to me again. (I still worry about it coming back, though.)

Interesting. I have to say though, there are gazillion variables here. Have you ever taken an extended leave from cannabis (at least a few months), and did you notice a return of these problems? Either way, I'm pretty sure there are some stoners with those kinds of health problems, so it probably doesn't work for everyone in that way.

I also think it may be meaningful to consider that the "mind" is just coming from the brain which is still just a part of the body. Like, I think it's not unlikely that even a lot of the psychological conditions psychedelics help with really probably just relate to something like them reducing inflammation in the brain. There are some ways that psychedelics seem to help me cognitively that seem purely mechanical, not related to the trip I actually had on them or anything, that I could easily see having that kind of explanation for how they work.

I'm increasingly coming around to this view myself, especially given my recent experiences. I've noticed that even when an experience has been rather "meh" or even crappy feeling, I've still gotten an impressively euphoric after-glow. At the same time, I'm not ready to dismiss the psychological process either. I think it's pretty obvious that psychedelics amplify psychological phenomena for better or worse. Is this purely an accident of nature? I don't think so, but how can I know for certain? I'll try to find out if I can. I will try not to take anything for granted either. I always try to remind myself not to be disappointed by unexpected and/or undesired outcomes because I really shouldn't hope for anything except to be enlightened as to nature's mysteries. Because when I am, I feel like the luckiest person alive.
 
Those are completely different things that I'm referring to, although I can understand conflating them from an outside perspective. The "clean and smooth and wonderful" feeling to me is just a feeling like I still feel physically healed after having had a trip, like I feel younger and more physically disinhibited again, and I have less pain and lethargy and such. It doesn't feel to me like I'm actually still tripping on anything, just like I'm still benefiting from having tripped.

The "spinning out of my mind in waves" that I describe from tryptamines literally does feel like I'm still tripping mentally for the next few days, and it doesn't have anything to do with feeling fresh and healed or anything. It feels inebriating to the point that sometimes I worry about my ability to do things that require me to be sober for the next few days still. It basically just feels like the cognitive effects of the drug outlive the immediate effects of the chemical actually being in my brain, and I still have to make my way down through them at the pace that they work at, whatever they may be. I do tend to find that this is common for me with tryptamines and uncommon for me with phenethylamines. On the other hand, I tend to feel refreshed after trips in the physical way from most psychedelics as I recall.

Thank you! This is the clarification I was looking for. I believe our experiences here differ. In addition to experiencing a "clean and smooth and wonderful" feeling afterwards, I also experiences feelings that resemble or reflect those of the trip itself. However, I generally find these feelings to be quite controllable and don't feel inebriated, as long as I stay sober.

Now if I smoke cannabis, it greatly amplifies these feelings and the cognitive intensity can be very significant. I like this effect very much because it's a lot like tripping on the thing I previously took, but it means that smoking weed isn't necessarily casual either unless I'm very careful guage my tolerance and mind the dosage.

I don't know how many people experience this from weed to the extent I do, but if you are a heavy cannabis smoker, this could be a major reason why your trips seem to keep going in the days after.

For what it's worth, that makes total sense to me, but I feel like there's a chance you're letting that experience cloud the picture of what 5-MeO-DMT is really like more generally, and I say that without even having tried 5-MeO-DMT yet myself.

There's a couple quick reasons I have to give for this.... The first is that I've actually seen scientific research that explicitly suggested that 5-MeO-DMT metabolizes into 5-HO-DMT/bufotenine when taken orally, and that taking 5-MeO-DMT with a MAOI also increases the amount of bufotenine that is formed and that remains in your system. From what I'm aware, bufotenine is a completely miserable substance to take orally, seeming to get entirely clogged up in the body and often producing just tons of uncomfortable physical side effects and usually little to no trip. Even when smoking bufotenine, I personally found it to be unusually body-heavy, compared to literally basically any other psychedelic I've ever tried. From what I can tell, I'm not the only person to think this way.

This is the first I've heard of this metabolic transformation, but it doesn't seem far fetched. I should note that MAOI + oral 5-Meo-DMT use is pretty widespread including in indigenous practices, and I've read a fair number of trip reports on it. It seems I'm not alone but only a small minority of people experience what I did. On the other hand, a lot more people find bufotenine to be objectionable, don't they? That would suggest there is at least more to the story here.

I just think I react unpredictably to tryptamines and have to use more care than most. For me now, given my age and health status, that means I probably won't touch any 5-Meo tryptamines again. Like even if something like 5-Meo-DMT is safe for me, I don't think I could have a comfortable trip given my fear of physical problems. I also know that under-dosing rather sucks. In fact, I did smoke 1 mg or so once and just felt terrible---very dizzy, nauseous, buzzy (in a bad way), with intense head pressure, a headache, and a weird feeling in my lungs and throat from the smoke. Do I really want to find out how it feels to smoke more though?

That said, I do think I'm going to try smoking DMT some day. In oral form, it could terrify me like nothing else, making me fear not that my body was going to die but that my soul itself was going to be lost forever, yet somehow I came away with the understanding that this was a psychic terror that arose from the profound ego destruction and not the actual condition of my body like with 5-Meo-DMT.

I haven't used 4-AcO-MiPT, but I have used 4-HO-MiPT plenty. I like it. It's not my favorite or the most impressive of the tryptamines for me, but it's probably generally the 4-substituted tryptamine I'd be most likely to take recreationally. It does have some notable similarities to mushrooms for me, but I find it to be more ornate, digital, and sexy. For years now I've described it as having a "burlesque" vibe. Fun stuff. Sometimes weird though too....

I think I had 4-HO-MIPT twice and 4-Aco-MIPT once. They felt quite similar, but the content of the three trips were all very different too. Both substances set in quicker orally than anything else I've had. To be clear, I'm usually at least alert within a few minutes even on phenethylamines, but with the 4-Aco-MIPT, I was feeling a strong come up by 5 minutes and was basically (+++) by 20 minutes. That trip was one of the most beautiful of my life by the way, flirting with a (++++) off of 14 mg fumerate.

I still haven't taken oral DMT unfortunately [...]

When you get around to it, be careful with it. Psychologically speaking, it is brutally powerful. I would say to prepare for total ego obliteration, but you can't really prepare for that. There's no transition to breathe through, nothing like that. Just BAM! The DMT vortex pulls you in and suddenly you know nothing about who you are, what you are doing, and why it's so damn hard to stay attached to your body. A sitter is a good idea, but he/she should understand it is no ordinary trip. In my first experience, my sitter who was quite experienced with acid was totally unprepared for supervising me on a high oral dose of DMT.

I really like DiPT too, and I'd really love it if I could have just the psychedelic trip without the unique auditory effects on top of it. Unfortunately, at any active dosage for the auditory effects for me, the way they make my ears feel is literally painful, causes a nonstop aggravating ringing, and it's so bad that I have spent an entire DiPT drinking alcohol just to distract myself from it.

Oh, that's too bad! I never experienced discomfort in my ears like that from DIPT. I suspect what you experienced wasn't actually physical, unless your blood pressure was screwed up or something. Hearing changes can strongly influence how you feel in other ways. For example, anechoic chambers cause many people to become very uncomfortable. Symptoms can include head pressure, vertigo, malaise, and nausea. This information may not be helpful to you, but it's something to keep in mind if you ever try DIPT again.

I've taken it up to 100 mg, which involved a surprisingly strong but brief tryptamine come-up followed by a rather modest feeling of alteration together with intense auditory effects. We put on "Star Wars: The Empire Strikes Back" because I wondered what Darth Vader would sound like. Turns out that Darth Vader just sounded like Darth Vader, but the other men sounded like Darth Vader too. Princess Leia meanwhile sounded like a dude. This was all tremendously amusing. The coolest audio hallucination though was my lady's microwave which was rather old and kind of noisy to begin with. That microwave sounded like it was literally trying to summon Satan. I even envisioned an evil red light emanating from the kitchen. It was the spookiest sound I've ever heard.

I've actually known a lot of people to praise rectal DPT, for what it's worth.

Thank you! If all I can get is HCl and don't want to do any chemistry, then rectal seems like the way to go.
 
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