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Ketamine salts solubility

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I don't think either will be orally active since their won't be the strong hydrogen-bonding between the phenolic -OH & tertiary amine. I would look at Nichols et al or even Isomer Design to see if they have been made. Synthesis would be interesting.
 
Skorpio said:
Psilocin with the alcohol group replaced with biosteres.

4-SH-DMT

Shares charge. Sulfur is more nucleophillic and bigger, would still have to fit in 5HT2A receptor pocket. Metabolism will be different due to oxidation potential of sulfur. Likely smells quite bad.


4-NH2-DMT

Swapping the alcohol for an amine might change its pKa too much and interfere with its charge at physiological pH, making it not cross membranes well.
Both of these were chosen because they would maintain the H-bond donor/acceptor character of the alcohol in psilocin.

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How do you post the pictures on here? Those are interesting chemicals btw!
 
Draw in ChemSketch (or whatever you use to draw structures), capture image (clip as needed) and use one of those 'free image upload' sites.
 
I love making chemicals I can sit there all day making them, but I just wish that I knew more about them, and chemistry in general. I'm a high school dropout, and the only info I got about this stuff is from searching about drugs on the internet. Lol 🤣
 
I’m not sure how active any of you are on neuroscience twitter, but it seems there is a schism developing among some prominent psychedelic scientists

From my understanding, it all started with this Nature Medicine article, which had a neuroimaging component:

Increased global integration in the brain after psilocybin therapy for depression


Surprisingly, there was no reference to previous psychedelic neuroimaging work done by Manoj Doss et al. See here:

Psilocybin therapy increases cognitive and neural flexibility in patients with major depressive disorder

Doss expressed his disbelief on twitter (see Doss’ reply to Carhart-Harris here) that this was an oversight, rather he seems to think it was a snub. And quite frankly, it is hard to believe that Carhartt-Harris et al would not have read that paper given how few psychedelic neuroimaging studies there are

Then, Doss et al released this critique of the original Nature Medicine article:

Skepticism About Recent Evidence that Psilocybin Opens Depressed Minds

Followed by a critique of the critique put out by Carhart-Harris et al:

A critique of: Skepticism About Recent Evidence that Psilocybin Opens Depressed Minds

And I’ve seen various (strongly worded) tweets from both sides as well. Too many to link them all but just browse through Doss and Carhart-Harris respective twitter accounts if you’re curious

I’m sure most of you have noted that this split falls pretty squarely between institutional lines, John Hopkins vs. Imperial College London

It would be sad to see any future collaborations squashed due to this beef

I don’t know what to make of it all tbh, I’m curious what others think
 
Forgot to mention, that the critiques are very strongly worded and in my opinion the one put out by Carhart-Harris et al borders on ad hominem attacks at some point

So it’s not just scientific discussion, to me it seems to be a genuine “conflict”
 
The Holy Quadruplty said:
There's a link to the chemical I created. I couldn't get it to upload on here. I really hope you can tell me what'd it would be called as it's an interesting chemical!
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I think the quora comment got it with: 4-dimethylamino,4-sulfanyloxy-1,1'-bipiperidine

However, I'm pretty sure it wouldn't be stable enough to exist. The thiol-oxygen linkage would be super unstable (like a peroxide)

Also the bipiperidine moiety looks awful close to some really carcinogenic things like biphenyls.
 
1-(1-naphthylmethyl)piperazine has been studied because of its ability to weaken the antibiotic resistance of bacteria, and I reckon it could be a stimulant similar to BZP. But that potentially carcinogenic naphthyl group is a problem in a compound that is likely to be needed in doses of hundreds of milligrams for a stimulant effect.

pubmed.ncbi.nlm.nih.gov

Effect of 1-(1-naphthylmethyl)-piperazine, a novel putative efflux pump inhibitor, on antimicrobial drug susceptibility in clinical isolates of Escherichia coli - PubMed

NMP is moderately active in reversing MDR in clinical isolates of E. coli and can partially restore fluoroquinolone susceptibility through inhibition of efflux pumps.
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
 
Fertile said:
The IUPAC name for the compound in the image is 4-(dimethylamino)[1,1'-bipiperidine]-4-OS-thioperoxol.

The thioperoxol isn't going to be very stable, or compatible with water.
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Are you talking about mine? Also can you name another one for me, or does it take too much work? I was was also wondering if you can name it like the type of names for example cuz idk what of name idk what it's called but like the type of name like Alprazolam is to Xanax, Clonazepam is to Klonopin, Buprenorphine is to Subutex, and so on. That type of name I'm talking about if you know what I mean. Yes I wanted the IUPAC name as well I'm just wondering if you can come up with what that one would be called too, or not?
 
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Also how is it possible for me to create a chemical, and say I'm the official creater of it? Can I create a molecule on like swiss that has very high probabilities for the right receptors, and be the real creater of it, or would I have to make it like ina lab or something like that or be a like famous chemist?
Fertile said:
The IUPAC name for the compound in the image is 4-(dimethylamino)[1,1'-bipiperidine]-4-OS-thioperoxol.

The thioperoxol isn't going to be very stable, or compatible with water.
Click to expand...
 
The IUPAC names of all of those are on their Wiki page.

Drug design used to be based on intelligent design and identification of QSAR. You can learn how to do that if you have 5-6 years spare. You need ChemOffice (or similar) to model overlays properly. There MAY be free UNIX alternatives. A lot of universities wrote their own software. FREE is a good price, so look into it.

These days high throughput screening is used in tandem with in siloco modelling. It seems an expensive option to me and isn't practical for a single person. I have often wondered WHO takes credit under such a system.
 
I Would Like To Take This Opprtunity To Point Out That Ethyl Alcohol, CH3CH2OH, Is The Oldest Synthetic Drug Know To Man, While Morphine, Ephedra, Cocaine, Nicotine, Marijuana, Caffeine, Theophylline, Theobromine, PEA, Mescaline, Psilocybin, Lysergic Acid, Salicylic Acid And Sugar Are 100% Natural Productos.
 
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