FDA Approves Seglentis: a strong prescription pain medicine that contains the opioid (narcotic) Tramadol and the NSAID Celecoxib

[dalpat077]

Seems like a win-win to me i.e. an opiod painkiller with a Nonsteroidal Anti-inflammatory Drug.

Seglentis: Uses, Dosage, Side Effects & Warnings - Drugs.com

Seglentis (celecoxib and tramadol) is used for the management of acute pain in adults. Includes Seglentis uses, side effects, interactions and indications.

www.drugs.com

I post this as I am only too well versed with the side-effects caused by something like Prednisone (a Corticosteroid) in heavy doses being prescribed to treat somebody with acute pain due to residual nerve damage. Maybe this is a better option is my point. Had to deal with this very thing this very week. And then this comes along as if by magic!

 

[darvocet21]

OSeems like a win-win to me i.e. an opiod painkiller with a Nonsteroidal Anti-inflammatory Drug.

Seglentis: Uses, Dosage, Side Effects & Warnings - Drugs.com

Seglentis (celecoxib and tramadol) is used for the management of acute pain in adults. Includes Seglentis uses, side effects, interactions and indications.

www.drugs.com

I post this as I am only too well versed with the side-effects caused by something like Prednisone (a Corticosteroid) in heavy doses being prescribed to treat somebody with acute pain due to residual nerve damage. Maybe this is a better option is my point. Had to deal with this very thing this very week. And then this comes along as if by magic!

Wizard is right that it's a questionable combination at best. The dose level of Tramadol makes no sense. I'm surprised Celebrex is even still being marketed after the justice department years ago forced Pfizer to pay $2.3 billion civil/criminal fine for fraudulent marketing of the related drug Bextra ( said the US attorney's in their press conference...see below) which they quietly withdrew from the market while leaving Celebrex the last man standing of a group of drugs with a bad profile of side effects especially when taken long term for chronic pain such as caused by arthritis



Tramadol on its own it's worth trying before you try something as strong as oxycodone. You won't have as much trouble finding a physician to prescribe it and there's a time-release formula which could be perfect for someone like you.

 

[dalpat077]

Wow, two lousy drugs mixed together (celebrex and tramadol) and only 44 mg of tramadol every 12 hrs to boot. If you’re in pain @dalpat077, you should be on a proper narcotic pain med like oxycodone or oxycodone and an NSAID.

Nah. Not me. I'm good. Just questioning some medical advice given to somebody else earlier this week and that makes absolutely no sense whatsoever to me.

Besides: I'd plaster the planet in Fentanyl patches for pain if it were up to me! And which I did suggest of course! Much to the dismay of said medical professional (specialist no less). Was informed that it was overkill. Also suggested Tramadol and Gabapentin. Nope. Lyrica is being suggested. Also being suggested is low dose tricyclic anti-depressants. Also not sitting right with me.

 

[dalpat077]

Wizard is right. Scandalous that Celebrex is even still being marketed after the justice department years ago forced Pfizer to pay $1.9 billion fine for deceptive marketing practices + playing down side effects of Celebrex ( said the US attorney's in their press conference... However Pfizer was not admitting any wrongdoing and probably paid one-tenth of 1% of its profits... no I take it back huge companies like Pfizer don't pay fines they had their accountants claim it as lost Revenue and deduct it from their corporate taxes)

See now that's interesting. I didn't know that. This stuff was approved not two days ago (Seglentis).

And here I thought I was wasting everybody's time by posting this!

Thanks for the information.

On the other hand: thanks for fuck all! Now I have to spend the afternoon investigating i.e. I'm a bit OCD when it comes to Pfizer!

 

[darvocet21]

I was wrong it wasn't Celebrex that Pfizer was fined for it was the closely related drug called Bextra. They're both cox-2 inhibitors and so is Vioxx which Merck was forced to stop selling. Here's the news conference back in 2012. I'm going to change the above post to reflect that. Again there was an agreement that Pfizer would not admit to any wrongdoing by agreeing to the approximately $2.3 billion (largest ever up to that point against a drug maker)

 

[dalpat077]

Alright then. In pfarirness to Pfizer:

Looks like something called Bextra was the real culprit and was taken off of the market. The safety of Celebrex was affirmed by the FDA in years to come i.e. 2018.

FDA Panel Affirms Safety Of Painkiller Celebrex

 

[dalpat077]

I was wrong it wasn't Celebrex that Pfizer was fined for it was the closely related drug called Bextra. They're both cox-2 inhibitors and so is Vioxx which Merck was forced to stop selling. Here's the news conference back in 2012. I'm going to change the above post to reflect that. Again there was an agreement that Pfizer would not admit to any wrongdoing by agreeing to the approximately $2.3 billion (largest ever up to that point against a drug maker)

Funny. I was just reading the exact same shit and we were obviously over typing each other!

Nevertheless: good information to have out there.

One article that I just read that will spoil your day: it is estimated that a) those fines accounted for about 3 months of Pfizer's profits and b) Pfizer themselves never took the rap but rather one of their acquisitions (Upjohn). Phew. Dodged that bullet!

 

[darvocet21]

Funny. I was just reading the exact same shit and we were obviously over typing each other!

Nevertheless: good information to have out there.

One article that I just read that will spoil your day: it is estimated that a) those fines accounted for about 3 months of Pfizer's profits and b) Pfizer themselves never took the rap but rather one of their acquisitions (Upjohn). Phew. Dodged that bullet!

The thing is you going to achieve an equal amount of pain relief with Naproxen than you are with Celebrex, which for some people is adequate but for many is not. But Naproxen is over the counter I believe you can even get it at the Dollar Store. None of these NSAIDs are good to take for years and years.

Personally I would take Tylenol and/or aspirin (or both together 325 mg aspirin 500mg acetaminophen) or I would take naproxen even though it takes a few days to start really working since it's long-acting... over ibuprofen which is prescribed in whopping doses of up to 800 mg and people think it's safe because it's available over-the-counter. It's implicated in heart attacks though too.

 

[dalpat077]

I have to say though:

On balance, and having lived with somebody (the patient) for over 10 years that's been on high doses of Prednisone from time to time, and having seen the side-effects, if it were me I'd take the chance on something like Celebrex any day of the week (assuming that a potential heart attack was the only possible issue is my point).

 

[darvocet21]

b) Pfizer themselves never took the rap but rather one of their acquisitions (Upjohn). Phew. Dodged that bullet!

Good to know if I ever commit fraud I'll make sure that somebody acquires me and that way I'll skate

I have to say though:

On balance, and having lived with somebody (the patient) for over 10 years that's been on high doses of Prednisone from time to time, and having seen the side-effects, if it were me I'd take the chance on something like Celebrex any day of the week (assuming that a potential heart attack was the only possible issue is my point).

It's not.

 

[dalpat077]

The thing is you going to achieve an equal amount of pain relief with Naproxen than you are with Celebrex, which for some people is adequate but for many is not. But Naproxen is over the counter I believe you can even get it at the Dollar Store. None of these NSAIDs are good to take for years and years.

Personally I would take Tylenol and/or aspirin (or both together 325 mg aspirin 500mg acetaminophen) or I would take naproxen even though it takes a few days to start really working since it's long-acting... over ibuprofen which is prescribed in whopping doses of up to 800 mg and people think it's safe because it's available over-the-counter. It's implicated in heart attacks though too.

Over typing each other again!

Yeah. My issues with all of this are a) the side-effects of high doses of Prednisone and b) supplementing with all sorts of other OTC painkillers. I mean to say: if nothing else this cannot be good for a person (liver, kidneys, whatever else). And this isn't something that can be fixed i.e. it is what it is. So it should, in my opinion, now be down to nothing else than daily pain management. No amount of Prednisone is going to reverse said condition is my point. So to me: just makes sense to slap on low strength (initially and monitor) Durogesic® DTrans® and stop taking all of the other shit. It's all about managing expectations i.e. there is no cure and nothing that's going to totally eradicate the pain so better to try and just alleviate it to a degree (the caveat being that said patient needs to be functional and is quite active).

 

[darvocet21]

Prednisone is really a drug of comfort for fairy advanced stages of terminal illnesses or frail and elderly people. My father was put on it for the last few weeks of his life. It's remarkably effective in those situations. But the side effects are probably not worth it if you are younger although I don't see any problem with taking prednisone PRN as long as you take it for a few days at a time and no more than once or twice a month tops and as small a dose as possible

 

[darvocet21]

Over typing each other again!

Yeah. My issues with all of this are a) the side-effects of high doses of Prednisone and b) supplementing with all sorts of other OTC painkillers. I mean to say: if nothing else this cannot be good for a person (liver, kidneys, whatever else). And this isn't something that can be fixed i.e. it is what it is. So it should, in my opinion, now be down to nothing else than daily pain management. No amount of Prednisone is going to reverse said condition is my point. So to me: just makes sense to slap on low strength (initially and monitor) Durogesic® DTrans® and stop taking all of the other shit. It's all about managing expectations i.e. there is no cure and nothing that's going to totally eradicate the pain so better to try and just alleviate it to a degree (the caveat being that said patient needs to be functional and is quite active).

Exactly. I'm more worried about the kidney damage from NSAIDs than anything else

 

[dalpat077]

Good to know if I ever commit fraud I'll make sure that somebody acquires me and that way I'll skate

It's not.

Fair enough. Oddly enough those side-effects are not too dissimilar to some of those of Prednisone seems to me. Where Prednisone falls real short is in compromising an already compromised immune system (in this case), mood swings, weight gain, the list goes on.

 

[darvocet21]

So to me: just makes sense to slap on low strength (initially and monitor) Durogesic® DTrans® and stop taking all of the other shit. It's all about managing expectations i.e. there is no cure and nothing that's going to totally eradicate the pain so better to try and just alleviate it to a degree (the caveat being that said patient needs to be functional and is quite active).

You really ought to look into Chiropractic and acupuncture and even massage. Unfortunately there's no good drug for long-term chronic pain. Fentanyl patches are probably the worst because as anybody on this site can tell you it stops working pretty quickly and you need to up the dose

 

[darvocet21]

Fair enough. Oddly enough those side-effects are not too dissimilar to some of those of Prednisone seems to me. Where Prednisone falls real short is in compromising an already compromised immune system (in this case), mood swings, weight gain, the list goes on.

Weight gain is one of its pluses when treating somebody who's suffering from terminal cancer

 

[Mr. Krinkle]

I'm surprised Celebrex is even still being marketed after the justice department years ago forced Pfizer to pay $2.3 billion civil/criminal fine for fraudulent marketing of the related drug Bextra ( said the US attorney's in their press conference...see below) which they quietly withdrew from the market while leaving Celebrex the last man standing of a group of drugs with a bad profile of side effects especially when taken long term for chronic pain such as caused by arthritis

Right....but Pfizer is an honest trustworthy company... don't worry about what's happened before with them it's all good now

 

[dalpat077]

You really ought to look into Chiropractic and acupuncture and even massage. Unfortunately there's no good drug for long-term chronic pain. Fentanyl patches are probably the worst because as anybody on this site can tell you it stops working pretty quickly and you need to up the dose

Guess it was shortsighted of me to not throw in the fact that it's just been discovered that some of the pain is attributed to the patient having a compressed disk in the lower back. Corrective surgery is not an option. And in not knowing too much about the physical aspects: does there not exist the possibility that some type of manual intervention could cause more damage or worsen the situation? That's the million dollar question here.

It's a kinda two fold pain problem. Residual effects (nerve damage) as a result of GBS contracted some many years ago. And now this disk issue (newly discovered). Fibromyalgia also being thrown into the mix (suspected at one time but no certainty on this).

As for patches: I could make the same argument re: the other medical suggestions. It wouldn't take long to develop a tolerance to Lyrica, any of the tricyclic anti-depressants (off label for pain and the actual mechanism for their off label use to treat pain not really clearly understood so far as I can tell), or Tramadol or Gabapentin no? And on the topic of using anti-depressants for their possible off label pain management benefits: doesn't make sense from the point of view that somebody with such severe pain doesn't need their head being fucked with as their mental fortitude is the only thing they have going for them and that allows them to keep pushing themselves physically (albeit that the dosage for such off label usage is far less than what would be prescribed to treat depression).

Weight gain is one of its pluses when treating somebody who's suffering from terminal cancer

Never thought of that. But we're not there (yet)!

 

[dalpat077]

Right....but Pfizer is an honest trustworthy company... don't worry about what's happened before with them it's all good now

Exactly!

Don't be nasty! Pfizer brought ya'll Xanax® and vaccines!

 

[darvocet21]

Guess it was shortsighted of me to not throw in the fact that it's just been discovered that some of the pain is attributed to the patient having a compressed disk in the lower back. Corrective surgery is not an option. And in not knowing too much about the physical aspects: does there not exist the possibility that some type of manual intervention could cause more damage or worsen the situation? That's the million dollar question here.

It's a kinda two fold pain problem. Residual effects (nerve damage) as a result of GBS contracted some many years ago. And now this disk issue (newly discovered). Fibromyalgia also being thrown into the mix (suspected at one time but no certainty on this).

As for patches: I could make the same argument re: the other medical suggestions. It wouldn't take long to develop a tolerance to Lyrica, any of the tricyclic anti-depressants (off label for pain and the actual mechanism for their off label use to treat pain not really clearly understood so far as I can tell), or Tramadol or Gabapentin no? And on the topic of using anti-depressants for their possible off label pain management benefits: doesn't make sense from the point of view that somebody with such severe pain doesn't need their head being fucked with as their mental fortitude is the only thing they have going for them and that allows them to keep pushing themselves physically (albeit that the dosage for such off label usage is far less than what would be prescribed to treat depression).

Amitriptyline is the best one. And also has a mild to moderate sedating quality which can come in handy when you're in pain.