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Arecoline Cocaine Analog/s

G

G_Chem

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I’ve been searching and hoping maybe someone here could help me. I’m wondering of the pharmacological action of the Arecoline Cocaine analogs I’ve heard of, has anyone ever actually tried these and reported on them? Or any pharmacological data to extrapolate from?

A fairly easy to synthesize Cocaine analog with at least 2x the potency of actual Cocaine, I’m surprised I haven’t heard much on it.

Any information is appreciated.

-GC
 
I never tried it, but I would imagine this arecoline derived compound would knock your socks off.

1-methyl-3-carbomethoxy-4-(phenyloxy)piperidine.png


1-methyl-3-carbomethoxy-4-(phenyloxy)piperidine
 
Lol, just what is needed for 1-methyl-3-carbomethoxy-4-PhenylPiperidine !
 
I guess you mean that the arecoline's double bond is hydroxylated and then the result esterified with benzoic acid...

start.png
 
All three of those molecules are probably psychoactive, but I would wager that mine is the best.
 
How could one phenylate the arecoline ?
 
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dalpat077 said:
Hi.

For the sake of interest:

Would these analogs (including 4-Fluorococaine as mentioned by @Gaffy on my other thread) be "rockable" or "cookable" (you know what I mean)?
Click to expand...

Most amines of that molecular size are solids when in freebase form, but if the substance is so effective that you can't estimate the dose visually then it's not a good one for smoking in a glass pipe. If you weigh the freebase with an accurate scale and absorb it in tobacco like PCP, then there wouldn't be a problem (unless the chemical is easily destroyed by high temperatures).
 
Most of the time halogenated chemicals tend to lose their bond, but seen the price of 4f-Caïne makes it a good research molecule that permits to create rounds to make a paper about the researches you've worked on.
 
Believe it or not, nitrocaine was pretty potent BUT the idiot producers hadn't noted the (very) low solubility of the hydrochloride which is is screws with the nose. Solubility in water = hydrochloride<<phosphate<sulfate i.e. .j.e. sulfate salts AN be snorted or indeed by IVed & smoked.

What can I say - I designed the lot but the boss went with the cheapest synthetic lab who put in a bid. Not smart..
 
clubcard said:
Believe it or not, nitrocaine was pretty potent BUT the idiot producers hadn't noted the (very) low solubility of the hydrochloride which is is screws with the nose. Solubility in water = hydrochloride<<phosphate<sulfate i.e. .j.e. sulfate salts AN be snorted or indeed by IVed & smoked.
Click to expand...

Some amines or carboxylic acids could even be so bad in that sense that they precipitate with the ions in your bloodstream. Oxalic acid forming calcium oxalate precipitates in the body is an example of this.
 
Potency isn't much, the problem is, if its not serotonergic like cocaine its not going to be the same (the high potency DRI analogs are also terrible). Its all about the DAT/NET/SERT ratios (although there isnt anything to say arecoline cocaine analogs would have less favorable ratios). Affinity for the norepinephrine transporter is important and necessary (but at the right amount). Ratios make up the drug qualitative properties (as does pharmacokinetics).

*Have they found a cocaine analog more reinforcing than cocaine?
 
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negrogesic said:
Potency isn't much, the problem is, if its not serotonergic like cocaine its not going to be the same (the high potency DRI analogs are also terrible). Its all about the DAT/NET/SERT ratios (although there isnt anything to say arecoline cocaine analogs would have less favorable ratios). Affinity for the norepinephrine transporter is important and necessary (but at the right amount). Ratios make up the drug qualitative properties (as does pharmacokinetics).

*Have they found a cocaine analog more reinforcing than cocaine?
Click to expand...
Being very primitive, I always simplistically viewed cocaine working most on dopamine- the reward/addiction neurotransmitter.

MDMA on both Serotonin and Dopamine.

And LSD more primarily serotonin.
 
negrogesic said:
Potency isn't much, the problem is, if its not serotonergic like cocaine its not going to be the same (the high potency DRI analogs are also terrible). Its all about the DAT/NET/SERT ratios (although there isnt anything to say arecoline cocaine analogs would have less favorable ratios). Affinity for the norepinephrine transporter is important and necessary (but at the right amount). Ratios make up the drug qualitative properties (as does pharmacokinetics).

*Have they found a cocaine analog more reinforcing than cocaine?
Click to expand...
Cocaethylene is one
en.m.wikipedia.org

Cocaethylene - Wikipedia

en.m.wikipedia.org en.m.wikipedia.org
 
AutoTripper said:
Being very primitive, I always simplistically viewed cocaine working most on dopamine- the reward/addiction neurotransmitter.

MDMA on both Serotonin and Dopamine.

And LSD more primarily serotonin.
Click to expand...

Yeah this a common but not holistic way of thinking about it. MDMA is not very adrenergic but if had no action on norepinephrine release/reuptake inhibitor it would be not nearly as reinforcing. It would be far more lethargic -- it wouldn't be MDMA.

Even LSD which is mainly serotonergic does have other activity and this is what makes it the unique drug it is.

Very strong and specific DRIs (like many cocaine analogs) just aren't that enjoyable.
 
Rectify said:
Dexmethylphenidate is more reinforcing than cocaine.
Click to expand...

I have a huge amount of experience with both having a heavy focalin habit for years and this wasn't true from my experience. Dexmethylphenidate is certainly highly reinforcing.

Reinforcing and enjoyable arent synonymous however. Some synthetic cathinones, for example 4F-PHP, are highly reinforcing but aren't very enjoyable.

I really liked dexmethylphenidate but cocaine blows it out of the water in terms of euphoria. This is due to its SERT affinity (that d-mph entirely lacks).
 
Let’s put it this way, as I lay in bed this morning my mind drifts as it usually does and I began thinking about the good cocaine I’d get as a teen. The smell, the taste, the subsequent high, for a moment in my half dream state I could actually feel it. It’s a drug I’ll always crave even with years of not touching it.

Focalin and Ritalin never elicit such a reaction. To me they’re garbage. I never could understand the comparison to be honest.

-GC
 
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