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Bupe Suboxone/Buprenorphine FAQ & Megathread v3; 2010 - 2022

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OpiumKing said:
Found a way to help my depression while on Suboxone or subutex: I have been on suboxone and now subutex for about 14 months now, and have tried a few things to help my depression without any luck. So decided to try ephedrine, and Wa-lah it has worked wonders.! I know it is difficult to get these days, but you can get it at Walmart or Walgreens by asking the pharmacist for primatene tablets. Primatene tablets have 12.5 mg of ephedrine, and 200mg of guaifenesin. They come in a box of 60 tablets. All you need is two tablets a day. I hope this helps some people, cause I have been trying to find something cheap to help with my depression for awhile now. Cheers, and good luck
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how and why would this help? only on 2MG myself and no problems on my end w/ bupe but just wondering why/how this benefits you.
 
There are a lot of different receptors in the brain, and a lot of drugs hit all manner of receptors. Some people who end up on Suboxone need something more than a partial opiate agonism for depression. I for instance need some NMDA atagonism every few week on top of what a partial opiate agonist provides me.
 
sometimes I feel its all a head game until you truly given up on the fact that dope/opiates have you by the balls (whatever) and you can beat this "disease" even when using a drug like sub/bupe.

I used hard for so many years and thanks to bupe things have calmed down drastically, almost to nothing besides an occasional slip, but I am a different person now and able to go days, weeks, months, without a care in the world or a thought that crosses the mind. of course, if something negative happens I need to talk myself out of doing the wrong thing but thats only here and there. for the most part, 2MG of bupe saves me daily; usually take my full 2MG dosage in the AM only. I started on 16MG and down to 2MG in less than a year; less is more in my eyes; there is no need. kills me to hear people say they have been on 16MG+ for 2-3yrs but did so little when it came to the drug itself. not all sub/bupe Dr's properly dose; they get paid, so who cares, they dont want you going anywhere, but people need to do their own research and not be scared to drop their own dosage. if others can do it, so can you.
 
My mate from high school had a codiene addiction and I mean 60 tabs a day addiction. (With all that paracetemol too) She did it fo ra few years and then it got to a point she looked very sick. After a long stint in hospital they replaced the 60 tablets with 32 mg of Suboxone daily now she is feeling sick... Do you guys think the conversion is wrong? Something seems very wrong.
BTW that's the most info I have.
 
^ Did they just induce the suboxone, or has she been on it for a while? How many mgs were the tabs?
 
knightworrier said:
My mate from high school had a codiene addiction and I mean 60 tabs a day addiction. (With all that paracetemol too) She did it fo ra few years and then it got to a point she looked very sick. After a long stint in hospital they replaced the 60 tablets with 32 mg of Suboxone daily now she is feeling sick... Do you guys think the conversion is wrong? Something seems very wrong.
BTW that's the most info I have.
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I guess they checked her liver enzymes ? Taking that much paracetemol daily will kill your liver.
And I guess one pill contains 15mg of codeine ?
If so that's 60*15 = 900 mg a day of codeine (some people say there's a ceiling effect after 600mg, meaning that if you take more than 600mg you won't get more effects, because all enzymes metabolising codeine into morphine are saturated)
Codeine is aroun 0.1 times as potent as morphine so 900*0.1 = equivalent to around 90mg of morphine
Buprenorphine is around 30-40 times as potent as morphine so 90mg/ 30 = 3mg
So 3mg should be enough, keep in mind that those numbers are just reference points and need to be taken with a grain of salt, as those opioids aren't completely cross tolerant etc. but still 32mg of bupe is way way way way too much for her.
 
knightworrier said:
My mate from high school had a codiene addiction and I mean 60 tabs a day addiction. (With all that paracetemol too) She did it fo ra few years and then it got to a point she looked very sick. After a long stint in hospital they replaced the 60 tablets with 32 mg of Suboxone daily now she is feeling sick... Do you guys think the conversion is wrong? Something seems very wrong.
BTW that's the most info I have.
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whoever gave her 32MG's of bupe should lose their job asap! that is farrrrrrr too much for someone w/ a codiene addiction, lol. this is why suboxone is abused; people do NOT UNDERSTAND how to substitute one drug for the other; I used to shoot 2-3G's of heroin daily; nowadays I take 1-2MG of Suboxone a day and feel on top of the world.

32MG of Suboxone is asking for trouble; you'd be more fucked up off the Suboxone than you were on the "drugs" you abused.
 
I had PW this morning...intensely...I have been shooting H all day to combat the effects. The question is...now that the sub is in my system and the PW is gone...can I safely take more even though I shot H to kill the PW?
 
subutex does not have naloxone in it. I was on 2 of the 2mg subutex pills a day and could take any opiate whenever I wanted and would work 100%. I'm now back on 2mg suboxone a day and if I wait just 6 hours I can take an oxycodone and still feel pretty great. That's just me.. I know for sure that not much of the naloxone, if any at all is absorbed in the body when taken sublingualy at a small dose such as 2mg/0.5mg. Point is that subutex is straight bupe and you will be able to do anything from popping a 5mg Vicodin to banging a bag of heroin.
 
Suboxone and subutex contain Buprenorphine, a partial opioid agonist that WILL block the effects of traditional opiates, AND cause precipitated withdrawl. There is a common myth that subutex won't cause blockage because it does not contain naloxone, truth of the matter is, naloxone is only added in Suboxone as a deterrent so addicts think twice about IVing, it is inactive sublingually ANYWAY, so whether you take subutex or suboxone, your still not going to feel the effects of opiates if you try to get high later that day, DEPENDING on how much suboxone or subutex you previously took that day. Usually when you take 8mg in a day, you will get almost complete blockage of opiates if attempted to get high, usually 85% of your opiate receptors are saturated, so expect huge disappointment.
Taking doses of 2-4mg of sub that. Day, gives you wiggle room to still feel effects of other opiates. Regardless if you take 1mg of suboxone, you will get COMPLETE BLOCKAGE from other opiates if you try to get high 1-4hrs after. You need to wait a good 6-8hrs to even feel other opiates if you don't exceed 4mg suboxone that day.
And YES, you STILL will go through precipitated withdrawal if you get high, and take a SUBUTEX after. Buprenorphine is what causes PWD. Naloxone is a deterrent in suboxone so addicts wont IV it, and even that is a whole other complicated subject i do not want to get into, basically, one can shoot suboxone and not go thru precip. WD, as bupe has a higher affinity than naloxone...subutex Suboxone. Tomato tamato
 
Not sure...totally new to the Sub world... Tried half of a 8mg sublingual strip approx 18hrs after last usage (IV heroin). I felt worse. Sweating, upset stomach...just all together worse. So I said f-it and got a sac. I've stupidly shot up twice now (yes, I know I am totally wasting it. It's just that I thought it would help take some of the edge off...which it kinda did...unless it's all mental. Whether it was in my head or not...either way, it sort of helped) Now, I felt absolutely zero rush nor any warm fuzziness that I was praying for. Plus, Im kicking myself for running back to heroin...my evil partner in crime. My question is...because I shot up twice will I have to wait the 12-24hrs to take more Sub or can I take the other half soon? Did I feel shitty because I took the Sub too soon? Any advice is appreciated...thank you.
 
Overitall said:
Not sure...totally new to the Sub world... Tried half of a 8mg sublingual strip approx 18hrs after last usage (IV heroin). I felt worse. Sweating, upset stomach...just all together worse. So I said f-it and got a sac. I've stupidly shot up twice now (yes, I know I am totally wasting it. It's just that I thought it would help take some of the edge off...which it kinda did...unless it's all mental. Whether it was in my head or not...either way, it sort of helped) Now, I felt absolutely zero rush nor any warm fuzziness that I was praying for. Plus, Im kicking myself for running back to heroin...my evil partner in crime. My question is...because I shot up twice will I have to wait the 12-24hrs to take more Sub or can I take the other half soon? Did I feel shitty because I took the Sub too soon? Any advice is appreciated...thank you.
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Yeah, bridging gaps between sub and dope is tough. I'd have to get at least 2 grams because I was probably going to waste the first gram being impatient and trying to break through the sub.

Take a smaller dose of sub after your last hit of heroin, I usually waited until I felt some type of WD. You take too much sub and it will make you sick, 4mg seems like a lot to me to take at once within 24 hours of last fix. Wait the 18-24 hours after last heroin hit and start with 1mg, wait an hour at least and take another 1-2mg until you feel fine. You will eventually get the hang for what is the right dosage and timing for you. Be patient, because taking too much sub too soon when you have heroin in your brain sucks a lot worse than feeling a little sick.

Having to bridge that gap it was costing me too much energy and money, so I gave up on heroin. I turned to IV'ing coc and taking benzos because sub doesn't block that stuff, and it's hella cheaper. Another really stupid decision in my life.
 
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Thank you for ur response. So now that I've shot up 4x's since I took the Sub and still no warm fuzzy feeling (swear I am waaay smarter than this...normally). Do I have to start over on the time or can I take another Sub in a few hours??
 
Ahh, someone can explain this better than me as to if the heroin is actually latched onto your receptors or if the suboxone blocked it.

I personally would always wait until I started feeling some WD and pinch off a corner of a sublingual strip, like .5mg, take it and wait to see how I feel and do it again if I was alright. It was a little uncomfortable but better than standing in a shower until the hot water runs out.

My doctor put it in Layman's terms for me....Think of your brain as a stadium. The heroin is filling up all the seats, when you start WD, the heroin is leaving the seats and you need to slowly fill in those seats with suboxone (my intial dose, not advice for bridging gaps lol). If too much heroin and suboxone are fighting over seats (you took too much sub or too soon) then you will go into WD.
 
Anyone have any opinions, knowledge, or experience with taking diphenahydromine while on suboxone? Is it bad to mix, will it help me sleep at all, does it possibly potentiate the partial agonist qualities of the bupe? These are all things I've considered that I can't find answers to on this very large thread. I'm asking cause I'm on suboxone and can't sleep. Have heard that some people, think somebody in this thread, mentioned it being an enjoyable combo, I'm just wondering how true any of it is and whether or not it will have enough of an effect on me to give me relief so I can sleep. I know if I was still withdrawaling I definitely wouldn't even consider taking the diphen, since it has always made me feel much much worse in the past. But since I'm on the sub, that shouldn't be a factor now.
 
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