Very impressive thread. It seems to have sparked a lot of interest in quite a few sites that I frequent.
I have a concern though, when taking DXM daily one would expect to build a tolerance to it, as one would to any other drug. So would that DXM tolerance affect it's ability to curb amphetamine tolerance?
I'd assume a tolerance would build to the other possible NMDA antagonists listed as well, considering that they're drugs just the same. If so, this presents a problem to the entire idea of using drugs to curb tolerance to other drugs..
No tolerance to the anti tolerance effect of NMDA antagonists wont occur.
I was also wondering if anyone who's been on a regimen could post their experiences? How efficacious the treatment is, what supplements were used, what doses were used, etc;
Check the link i posted above, i collected a lot of anecdotal experiences.
also a bit of food for thought; DXM has been known to potentate amphetamines, could this be a possible mechanism as to why one feels that their tolerance is lowered? Simply abstaining from taking any NMDA antagonists or amphetamines for a day or two and then dosing your average dose of amphetamines would probably clear that up.
No, the reason NMDA antagonists work is probably because they increase dopamine receptor density and effectively counteract downregulation.
If they worked just by potentiating amp, then tolerance would still occur after a while.
Couple refs:
(PMID: 1382178) Chronic administration of NMDA antagonists induces D2 receptor synthesis in rat.
D2 binding studies carried out in MK-801 chronically treated (0.3 mg/kg/day per os, for 50 days) and control rats revealed an increased receptor density in treated animals without a significant change in receptor affinity.
(PMID: 10443547) Adaptations of NMDA and dopamine D2, but not of muscarinic receptors following 14 days administration of uncompetitive NMDA receptor antagonists.
The same treatment with amantadine did increase [3H]raclopride binding to dopamine D2 receptors by 13.5%.
(PMID: 12832726 Effect of combined treatment with imipramine and amantadine on the central dopamine D2 and D3 receptors in rats.
We can conclude that repeated administration of AMA, given together with IMI, induces the up-regulation of dopamine D2 and D3 receptors in the rat brain.
(PMID: 10096038) Modulation of dopamine D2 receptor expression by an NMDA receptor antagonist in rat brain.
In the striatum, a significant increase in striatal dopamine D2 receptor mRNA levels was shown in animals treated with CPP.
Also, magnesium is often used as an antacid. Antacids increase amphetamine absorption. Could this be the real mechanism in action as opposed to the NMDA antagonist theory?
So far I can find little research on the topic, so anecdotal evidence seems like the only way to go, as unreliable as it may sometimes be. I think we need ample evidence before starting a similar regimen, as NMDA antagonists seems to have a 'dumbing down' effect which would be contraindicated in therapeutic use.. anyone who's ever done high doses of DXM should be familiar with that. Personally, I feel like a goddam retard when I take ~240mg.
Memantine has little cognitive effects in most people after the adaptation phase, i take 60mg /day and only notice extra clarity, altough there can be some decline, i dont notice it.
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