Literature reports about mitragynine toxicity in humans are rare, even if in recent years clinical cases are increasing. Only two papers reported cases of hepatotoxicity following kratom consumption; the first one was published by Kapp et al. in 2011 involving a 25-year-old man, the second one was described by Dorman et al. in 2015, involving a 58 year old man.
Although in both cases the available data were significantly suggestive of kratom induced hepatotoxicity, the authors of both studies due to the lack of scientific data on the toxicity of kratom in humans, were cautious in confirming unequivocally this association; in the first case the physicians could not directly correlate the onset of acute liver disease with the intake of kratom, taking into account that the effects of the substances contained in M. speciosa extract (alkaloids, saponins, flavonoids, etc.) have not yet been fully investigated making the correlation between the state of the liver and the intake of these preparations very difficult, whereas in the second case report, the authors defined idiosyncratic the onset of liver complications but evaluated as ?convincing? its association with the intake of kratom. However, it still remains to be established if the onset of liver complications could be attributable to kratom alkaloids, extract-production byproducts, or other contaminants
I don't want you to keep escalating and get to that point where you no longer receive any benefit from the drug aside from withdrawal symptom mitigation. This is pretty normal stuff and the problem is that folks can get their hands on a shit ton of this stuff for cheap. I am a compulsive drug user and I cannot keep Alcohol in my house and if drugs are begun, the drugs will be finished. This may not be you, but as a former Heroin addict, I could not handle a giant bag of Opioid under my roof.
