5-HT/Mexamine/5-Methoxytryptamine authenticity

[Tris_legomenon]

I've been doing some research into mexamine, which is a possibly psychedelic relative of melatonin and a full 5HT2A receptor agonist.

1. Does anyone have any experience with this? Trip reports are really hard to find. There are a couple on erowid, a little bit on here and Reddit, but nothing substantial.

2. Does anyone know what a good starting dose might be? I've been reading what scientific literature I can find, but most of those are not oral dosages in humans. Also, it's destroyed by MAO, so i believe it needs a MAOI. I've got hordenine; would that work?

3. How would I go about testing its purity? The places that have it online, without being too specific here, are places I feel the need to test from, and I don't know how to interpret the results of a reagent test for something this obscure. Would it come up like a tryptamine? Would it come up as melatonin?

Any input on this substance is appreciated thanks!

 

[kleinerkiffer]

Welcome to Bluelight
I think this thread would be more suited for http://www.bluelight.org/vb/forums/155-Neuroscience-and-Pharmacology-Discussion

5-MT looks like an interesting drug and I couldn't find much either
From Tihkal

Removal of both methyl groups from the nitrogen gives 5-methoxytryptamine (5-MeO-T) which has been explored most extensively by Soviet researchers as a treatment for exposure to radiation. It is also known by the trade name Mexamine and has been looked at as a potentiator of centrally active drugs.

To test its purity something like GC-MS or NMR would be best (but this'll cost quite a lot of money if you find someone that'll do it) for spectra check out those links http://www.hmdb.ca/metabolites/HMDB0004095 and https://pubchem.ncbi.nlm.nih.gov/compound/5-methoxytryptamine#section=1D-NMR-Spectra

If you check the wikipedia article you can see that it has relatively high affinity for the 5-HT2B receptor

5-HT2B receptors (Ki = 16.4 nM)

, this is bad news as this receptor is implicated in heart problems with chronic use(i.e. valvulopathy and maybe heart failure)