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Opioids Increasing Oral DHC bio availability?

R

Razu

Greenlighter
Joined
Sep 6, 2018
Messages
11
Hey, is there a way to increase the oral Dihydrocodeines oral bio availability since its only 20%, Would alcohol help?
 
if we can trust wikipedia
Although dihydrocodeine does have extremely active metabolites, in the form of dihydromorphine and dihydromorphine-6-glucuronide (one hundred times more potent), these metabolites are produced in such small amounts that they do not have clinically significant effects.
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you could increase the bioavailability by inhibiting the metabolism via CYP2D6 and CYP3A4 by drinking white grapefruit juice
 
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