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Beating Vivitrol?

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prumpkinstein

Greenlighter
Joined
Oct 29, 2018
Messages
4
My posts keep getting closed in BDD because its a "getting high" thread so I thought maybe I could ask this here:

Is there anything I can do to remove the naltrexone from my system after a vivitrol shot? Like any pharmacology that will help remove it from my system faster, or just remove it completely?

I'm on day 9 of my shot and want to get it out as quick as possible. Thanks!
 
Nothing aside from time is going to help. There is no magical way to make your body excrete/eliminate it in a short amount of time.
 
Buprenorphine can be helpful in cases of hyperalgesia but you certainly won't get high. Be very careful indeed and ask a specialist as you can still OD.
 
is it true if you drink alcohol on naltrexone you will get sick? im thinking of using it but if i drink i dont get ill
 
Every time I see a thread like this with questions about how long their naltrexone will work or how to excrete it faster, it makes me wonder why in addiction management we're still at the level of making opioid addicts not take drugs by force instead of helping them change their mindset. It reminds me of times here when there was no methadone available and a common method to get people off heroin was to make them tough it out in in-patient rehabs, it wasn't that long ago, just ~20 years and even today capacity of maintenance programs is well below the needs. Such an approach is doomed to failure, one way or another. Making people take naltrexone shots is really no different, if your cravings are so strong that you count down the days before you can shoot up again, how is it supposed to be helping you? It won't make you change your mindset no matter how long it will block your opioid receptors.
 
uhm i think you are a bit outdated. now we have suboxone, which is simple easy fast way to beat h withdrawals in the setting of your home instead of going to methadone clinics. anyway, i completely agree with you. they are making it more and more convenient for h addicts to keep wanting h because its so simple fast, easy to deal with withdrawals now days. i remember in my day, ill vomit and shit myself for weeks and have major depression and suicidal ideation for half a year after each quit of heroin. still less than alcohol withdrawal though, that can last a year and to this day, there is no magic pill like suboxone or even methadone :S
 
Naltrexone has a higher Ki at the μ receptors (0.33 vs 0.77 for buprenorphine) but a lower affinity at the κ & δ. I don't know if delta agonism will help with abstinence syndrome but you won't find anything to break the blockade. As I said - buprenorphine can help with the hyperalgesia but alcohol is most certainly contraindicated.
 
Nalmefene (Selincro) seems to be used to treat alcoholism in Europe.
 
S.J.B. said:
The consumption of alcohol is contraindicated, which would make sense for an alcoholism treatment.
Click to expand...

The whole point is that you CAN drink on naltrexone but it reduces the euphoria. The reason nalmefene has superseded naltrexone in developed nation is that naltrexone's delta & ORL1 affinity is such that given a sufficient amount of alcohol, naltrexone doesn't eliminate ALL euphoria. This is a VERY well studied set of compounds so it isn't that the data isn't available - it's that some people don't bother checking it.
 
this is interesting to use naltrexone to prevent drinking because it doesnt get you high. i have an alcohol problem and i dont drink to get high, i drink to get dissociated and confused i almost never get euphoria from alcohol. i use heroin to get euphoria, thats why i mix those two sometimes, to get real dissociated and also euphoric. so i dont understand how naltrexone lowering your ability to experience euphoria from alcohol (which i dont) might help??
 
I'm guessing that having a high opioid tolerance also reduces the euphoria from alcohol. I tend to get euphoria from alcohol after the third drink but before anaesthesia sets in.
 
asecin said:
this is interesting to use naltrexone to prevent drinking because it doesnt get you high. i have an alcohol problem and i dont drink to get high, i drink to get dissociated and confused i almost never get euphoria from alcohol. i use heroin to get euphoria, thats why i mix those two sometimes, to get real dissociated and also euphoric. so i dont understand how naltrexone lowering your ability to experience euphoria from alcohol (which i dont) might help??
Click to expand...

Still the addiction is mediated by dopamine, isn't naltrexone working simply by blocking dopamine pathway that is responsible for compulsion to repeat pleasurable activity and thus developing addiction? If you stop associating an activity with pleasure, the link between this activity and desire to repeat it is weakened. Or perhaps it blocks pleasurable effects of alcohol, by blocking opioid receptors it might indirectly inhibit signalling responsible for feeling pleasure.
 
I know what it is to drink just to manage another day so I know naltrexone has no benefit for the people in that boat. I spend 15 months necking 2 bottles of vodka a day (1.5). I decided to stop and the doc gave me 5mg chlorodiazepoxide.... pointless. I ordered 84 clomethiazole and came off after 12 days. The alcohol in shops and stores freaked me out. I mean it looked so evil. If you can DIY then you can do it. I don't know where you can obtain clomethiazole (although LC seems to know) but I got it via a forged script in Spain. I'm not proud.

Still - 14 years and counting. WTF is Freeblood when we need his work?
 
asecin said:
is it true if you drink alcohol on naltrexone you will get sick? im thinking of using it but if i drink i dont get ill
Click to expand...

You're thinking of disulfiram (Antabuse). It's largely been relegated to the trash bin of AUD treatment, although I know several hardcore old-timers who still use it. There are much better developed therapies available now.
clubcard said:
The whole point is that you CAN drink on naltrexone but it reduces the euphoria.
Click to expand...

Oral naltrexone did bupkis for me, except make me sick as shit like I was going through acute opioid WD a few times, which is why I always said no to the shot. I wasn't court ordered to take it, so that wasn't an issue for me. I've also been drunk as shit on naltrexone and it didn't feel any different than any other drunk. But, I've known people with AUD who swear by the Sinclair Method.
clubcard said:
I know what it is to drink just to manage another day so I know naltrexone has no benefit for the people in that boat.
Click to expand...

Agreed
clubcard said:
I decided to stop and the doc gave me 5mg chlorodiazepoxide
Click to expand...

Last time I went to an emergency room wanting to be admitted to the hospital for alcohol detox, the ER doc just sent me home after a few hours with a short script for 25mg chlordiazepoxide, and even that was a joke, so 5 would IMO be no better than taking a sugar pill. I did better using the Ativan I'm already prescribed for acute anxiety and panic.
 
clubcard said:
I know what it is to drink just to manage another day so I know naltrexone has no benefit for the people in that boat. I spend 15 months necking 2 bottles of vodka a day (1.5). I decided to stop and the doc gave me 5mg chlorodiazepoxide.... pointless. I ordered 84 clomethiazole and came off after 12 days. The alcohol in shops and stores freaked me out. I mean it looked so evil. If you can DIY then you can do it. I don't know where you can obtain clomethiazole (although LC seems to know) but I got it via a forged script in Spain. I'm not proud.

Still - 14 years and counting. WTF is Freeblood when we need his work?
Click to expand...


i heard a lot of good about clomethiazole in stopping alcohol. but why isnt it more popular and used here in the US? i dont understand the problem with the americans not prescribing it!? btw how did it make it so you found alcohol repulsive? its a benzo, it shouldnt be making alcohol any less enticing

aihfl said:
[/COLOR]
You're thinking of disulfiram (Antabuse). It's largely been relegated to the trash bin of AUD treatment, although I know several hardcore old-timers who still use it. There are much better developed therapies available now.


Oral naltrexone did bupkis for me, except make me sick as shit like I was going through acute opioid WD a few times, which is why I always said no to the shot. I wasn't court ordered to take it, so that wasn't an issue for me. I've also been drunk as shit on naltrexone and it didn't feel any different than any other drunk. But, I've known people with AUD who swear by the Sinclair Method.


Agreed


Last time I went to an emergency room wanting to be admitted to the hospital for alcohol detox, the ER doc just sent me home after a few hours with a short script for 25mg chlordiazepoxide, and even that was a joke, so 5 would IMO be no better than taking a sugar pill. I did better using the Ativan I'm already prescribed for acute anxiety and panic.
Click to expand...

same here. they keep giving me crappy librium for any alcohol w/d in the ER. never helped but made me super sick and sedated for days. how is valium not better than either both ativan or librium?

atara said:
I'm guessing that having a high opioid tolerance also reduces the euphoria from alcohol. I tend to get euphoria from alcohol after the third drink but before anaesthesia sets in.
Click to expand...

yeh i made the mistake of mixing opiates with alcohol for too long ending up with alcohol giving me zero pleasure without the opiates. in a way its a good way to quit alcohol i suppose but in another way, i was trying to beat opiates by switching to alcohol. not sure how to approach the situation by quiting them both
 
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Chlormethiazole is no benzo. And as for the US..perhaps because it is one of those oldschool wall-banger GABAergics which mostly got shitcanned for such reasons, such as methaqualone, ethchlorvynol etc.?

It also has a very low tolerance for people fucking about stupidly on it, and an OD could easily be lethal, as with the likes of barbs.

As for where...well there is at least one RC place that carries it in existence, although my own source is a legit script, plus DIYing it if I want more. I mainly use it for seizure prophylaxis and treatment. Not much of a drinker to begin with myself, but I can't say it's any worse on it than of it. Although mixing the two, if done at all, ever, must only be done by someone already familiar with chlormethiazole and the way it affects them and at what doses, very slowly increasing from microdosed alcohol. Not a good idea though.
 
S.J.B. said:
The consumption of alcohol is contraindicated, which would make sense for an alcoholism treatment.
Click to expand...

a lil bit off topic tho, im on bupe without naltrexone (subutex) & since i'm on it i can't touch a slurp of a beer, normally normally drinkinking whiskey by cups & downing it with beer... i just cant stand the taste & if i force myself i do get slightly sick. even after a khat session (yeah im lucky inuff to live in a country with fresh, legal qat & also imported from ethiopia 3 times a week. local khat for all day cost me like 20$, imported like 30$. my bupe doc said he ''heard about this side effect''.
never much liked alcohol tho, & never ever want to mix it with opiates, but having a trouble to have a beer??? :(
 
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im surprised you guys never mixed alcohol with opiates. its pretty damn nice, but maybe dangerous if you overdo it. thats why carrying narcan spray is recommended, as thats what i do.
 
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