Neuroprotection
Bluelighter
- Joined
- Apr 18, 2015
- Messages
- 1,088
Hi all,
I want to apologise in advance for the fact I can?t post links to studdies due to my blindness
Also, just want to say I have been obsessed with the following topic for years and hope to get as many people on bord as possible, I feel it has the potential to transform our lives.
Cell death, most notably apoptosis and necrosis have both beneficial and detrimental affects in the body and especially in the brain, where it plays an important role in development and neurodegeneration.
My interest is in the role of apoptosis and necrosis in learning, memory and drug abuse/addiction.
I would like to start and encourage a theoretical discussion about the possible inhibition, by small molecules, of these pathways and if this could lead to extraordinary nootropic, neuroprotective or other medically relevant affects.
Through my research, I have found that blocking one cell death pathway can activate another, e.g. Caspase3 inhibition blocks apoptosis but can exacerbate necrosis. On the other hand, blocking RIPK1, involved in necrosis can lead to apoptosis. Therefore in my opinion, (Im no biology expert so please correct me if im wrong) it is important to target the final affector of most cell death pathways, the mitochondrial Permiability Transition Pore (MPTP).
I have read that blockade of the MPTP by cyclosporinA analogs which lack immuno-suppression, can trigger intence neuronal stem cell proliferation and neurogenesis as well as protection of mature neurons from insults ranging from protein agrigates to heavy metals and neurotoxic drugs.
What are your thoughts.
I would very much welcome imput from any specialists in the field of cell death.
What are your opinions on the risks and benefits of blocking cell death for short time periods to protect against neurotoxic drugs e.g. methamphetamine or in those suffering strokes or other brain injuries?
Thanks
I want to apologise in advance for the fact I can?t post links to studdies due to my blindness
Also, just want to say I have been obsessed with the following topic for years and hope to get as many people on bord as possible, I feel it has the potential to transform our lives.
Cell death, most notably apoptosis and necrosis have both beneficial and detrimental affects in the body and especially in the brain, where it plays an important role in development and neurodegeneration.
My interest is in the role of apoptosis and necrosis in learning, memory and drug abuse/addiction.
I would like to start and encourage a theoretical discussion about the possible inhibition, by small molecules, of these pathways and if this could lead to extraordinary nootropic, neuroprotective or other medically relevant affects.
Through my research, I have found that blocking one cell death pathway can activate another, e.g. Caspase3 inhibition blocks apoptosis but can exacerbate necrosis. On the other hand, blocking RIPK1, involved in necrosis can lead to apoptosis. Therefore in my opinion, (Im no biology expert so please correct me if im wrong) it is important to target the final affector of most cell death pathways, the mitochondrial Permiability Transition Pore (MPTP).
I have read that blockade of the MPTP by cyclosporinA analogs which lack immuno-suppression, can trigger intence neuronal stem cell proliferation and neurogenesis as well as protection of mature neurons from insults ranging from protein agrigates to heavy metals and neurotoxic drugs.
What are your thoughts.
I would very much welcome imput from any specialists in the field of cell death.
What are your opinions on the risks and benefits of blocking cell death for short time periods to protect against neurotoxic drugs e.g. methamphetamine or in those suffering strokes or other brain injuries?
Thanks