This might be a really stupid questions but I cant stop thinking about it. Lets say a opiate naive individual kept taking naloxone for a long period, enough to get "addicted" to it. Would stopping it cause a widthdrawl that would feel like a opiate high? My theory is that prolonged exposure to naloxone would cause upregulation of opioid receptors causing them to be super sensitive to endogenous endorphins thus resulting in a high when sober.