Hi,
I'm looking for data concerning:
Ethchlorvynol (+it's carbamate ester)
Ethinamate
Hexapropymate
Methylpentynol (+it's carbamate ester)
Tert-Amyl alcohol (+it's carbamate ester)
I know ethchlorvynol binds at the picrotoxin/benzodiazepine site but I cannot find affinity data for the others. This data is not so I can brew up some 'super alcohol' but rather to decide if we should apply for a licence for 1B trials for 5-(2-chlorophenyl)-7-ethynyl-1-methyl-1,3-dihydro-2H-1,4-benzodiazepine-2-thione. I can assure you that unless you knew, you would NEVER guess that it's a benzo. I suspect that the terminal alkyne, being acidic, is binding (if only for transition) to the cations of NaCl, KCl & CaCl2 thus increasing the number of Cl- ions available to pass through the -Cl gate.
But I could well be wrong!
Cheers,
CC
I'm looking for data concerning:
Ethchlorvynol (+it's carbamate ester)
Ethinamate
Hexapropymate
Methylpentynol (+it's carbamate ester)
Tert-Amyl alcohol (+it's carbamate ester)
I know ethchlorvynol binds at the picrotoxin/benzodiazepine site but I cannot find affinity data for the others. This data is not so I can brew up some 'super alcohol' but rather to decide if we should apply for a licence for 1B trials for 5-(2-chlorophenyl)-7-ethynyl-1-methyl-1,3-dihydro-2H-1,4-benzodiazepine-2-thione. I can assure you that unless you knew, you would NEVER guess that it's a benzo. I suspect that the terminal alkyne, being acidic, is binding (if only for transition) to the cations of NaCl, KCl & CaCl2 thus increasing the number of Cl- ions available to pass through the -Cl gate.
But I could well be wrong!
Cheers,
CC