This is an interesting old paper: Low dose Ibogaine robustly increases memory retrieval by almost 100% in rats.
Facilitation of memory retrieval by the "anti-addictive" alkaloid, ibogaine. Popik P.
Life Sci.1996;59(24)L379-85.
Abstract:Anecdotal observations in humans indicate that indole alkaloid ibogaine may have anti-addictive properties. It has been suggested that the therapeutic action of ibogaine may depend upon facilitated access to the past experiences, purportedly influencing the initiation of drug addiction. To determine if ibogaine may facilitate memory retrieval, rats were trained in the Morris maze spatial navigation task. It has been found that ibogaine (0.25 or 2.5 mg/kg) or O-desmethyl-ibogaine (2.5 mg/kg) but not t-Butyl ibogaine, administered just before the test trial, facilitated spatial memory retrieval compared to rats receiving placebo treatment. It is concluded that although previously described NMDA receptor antagonistic properties of ibogaine may represent a locus for at least some of its actions, other mechanisms, involving facilitation of memory retrieval may be of importance for its anti-addictive effects.
Dose of 0.25mg/kg to 2.5 mg/kg in rats correspond roughly to 0.04 to 0.4 mg/kg in humans. So for an average 70kg human, this is about a 3 to 30 mg dose which is between 30 to 1000 times lower doses than used in addiction (1000-2000 mg).
Now my question is this: what is exactly "spatial memory"? how is it different from other type of memories like recalling answers to a test. Or is "spatial memory test" used in rats to measure memory retrieval in general since you can't ask rats if they recall what you told them last week unlike humans. If that is the case then this the single most potent and unique nootropic that Universities and academics should make illegal. Like some nootropics are being banned in some top Ivy League schools. I actually agree it would be like cheating if one student can double his memory recall capacity on exam day by taking couple mg of a memory retrieval pill. While other students dumb it out
nb: The highest dose of Ibogaine used by that study (30 mg) is not psychoactive at all. and this is not a memory enhancing smart drug like other cholinergic nootropic smart drugs on the market but "on-demand" memory recalling smart drug. It is kind of different. The former enhances memory storage, the latter increases recalling ability of stored memory.. But we talking about rats.. then again no much difference between rats and humans