Jabberwocky
Frumious Bandersnatch
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A billionaire pharmaceuticals executive who has been blamed for spurring the US opioid crisis stands to profit from the epidemic after he patented a new treatment for drug addicts.
Richard Sackler, whose family owns Purdue Pharma, the company behind the notorious painkiller OxyContin, was granted a patent earlier this year for a reformulation of a drug used to wean addicts off opioids.
The invention is a novel form of buprenorphine, a mild opiate that controls drug cravings, which is often given as a substitute to people hooked on heroin or opioid painkillers such as OxyContin.
The new formulation as described in Dr Sackler?s patent could end up proving lucrative thanks to a steady increase in the number of addicts being treated with buprenorphine, which is seen as a better alternative to other opioid substitutes such as methadone.
Last year, the leading version of buprenorphine, which is sold under the brand name Suboxone, generated $877m in US sales for Indivior, the British pharmaceuticals group that makes it.
Before the opioid crisis, the Sackler family was primarily known for its philanthropy, emerging as one of the largest donors to arts institutions in the US and UK. But the rising number of addictions and deaths has highlighted the family?s ownership of Purdue, which some members have tried to shy away from.
It?s reprehensible what Purdue Pharma has done to our public health
Luke Nasta, director of Camelot
Dr Sackler?s patent, which was granted by the US Patent and Trademark Office in January, acknowledges the threat posed by the opioid crisis, which claimed more than 42,000 lives in 2016.
?While opioids have always been known to be useful in pain treatment, they also display an addictive potential,? the patent states. ?Thus, if opioids are taken by healthy human subjects with a drug-seeking behaviour they may lead to psychological as well as physical dependence.?
It adds: ?The constant pressures upon addicts to procure money for buying drugs and the concomitant criminal activities have been increasingly recognised as a major factor that counteracts efficient and long-lasting withdrawal and abstinence from drugs.?
However, the patent makes no mention of the fact that Purdue Pharma has been hit with more than a thousand lawsuits for allegedly fuelling the epidemic ? allegations the company and the Sackler family deny.
?It?s reprehensible what Purdue Pharma has done to our public health,? said Luke Nasta, director of Camelot, an addiction treatment centre in Staten Island, New York. He said the Sackler family ?shouldn?t be allowed to peddle any more synthetic opiates ? and that includes opioid substitutes?.
Buprenorphine is prescribed to opioid addicts in tablets or thin film strips that dissolve under the tongue in less than seven minutes. These ?sublingual? formulations are used to stop drug abusers from hoarding a stockpile of pills they can sell or use to get high at a later date.
The patent describes a new, improved form of buprenorphine that would come in a wafer that disintegrated more quickly than existing versions ? perhaps in just a few seconds.
The original application was made by Purdue Pharma and Dr Sackler is listed as one of the inventors alongside five others, some of whom work or have worked for the Sackler?s group of drug companies.
?Drug addicts sometimes still try to divert these sublingual buprenorphine tablets by removing them from the mouth,? the patent application stated. ?There remains a need for other . . . abuse-resistant dosage forms.?
In June, the Massachusetts attorney-general filed a lawsuit against Dr Sackler and seven other members of the Sackler family, which accused them of engaging in a ?deadly, deceptive scheme to sell opioids?.
Purdue and the family deny the allegations and Purdue said it intends to file a motion to dismiss. The company points out that OxyContin was, and still is, approved by the US Food and Drug Administration.
?We believe it is inappropriate for [Massachusetts] to substitute its judgment for the judgment of the regulatory, scientific and medical experts at FDA,? it said in a recent statement to the Financial Times.
Andrew Kolodny, a professor from Brandeis University who has been a vocal advocate for greater use of buprenorphine to battle the opioid crisis, said the idea Dr Sackler ?could get richer? from the patent was ?very disturbing?. He added: ?Perhaps the profits off this patent should be used to pay any judgment or settlement down the line.?
Earlier this week, Purdue donated $3.4m to boost access to naloxone, an antidote given to people who have just overdosed on opioids.
Source: https://www.ft.com/content/a3a53ae8-b1e3-11e8-8d14-6f049d06439c
