Hey guys recently have gone through a year without being able to enjoy opiates due to antipsychotics and antidepressants, now I'm finally well clear of either of the two I am only currently taking lithium, but I'm still feeling almost no effect of opiates still is there possibly a problem between thev lithium and oxycodone ive been using? Couldn't find much about the two on The internet so any help would be much appreciated thanks!
Opioids Lithium and oxycodone
- Thread starter Adrianm12
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Can't believe it I thought switching to lithium I was finally going to have a medication that didn't block out my opiates
been looking abit more on Google finding some stuff about lithium acting on dopamine but there's not much description, thank you for the reply though
Jekyl Anhydride
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Here's some anecdotal reports of a similar problem:
Some of these people also report long lasting opioid high/ efficacy mitigation even after discontinuation from AD's.
-Opiates-not-having-full-effect-due-to-SSRI
But there's hope..
Hope it works out Adrian
Some of these people also report long lasting opioid high/ efficacy mitigation even after discontinuation from AD's.
-Opiates-not-having-full-effect-due-to-SSRI
But there's hope..
Hope it works out Adrian
Thanks for your reply jekl much appreciated luckily lithium half life isn't too crazy I might wait a few days without taking it then try again to see if that was the problem
Jekyl Anhydride
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Yeah D1nach raises a good point, I only presented one side of things. Def make sure to balance the importance of what Lithium does for you before chucking it, esp if the opioids are recreational.
While i do not recommend this, and i take amphetamine (different but similar in it lithium supposedly weakens it according people) and notice absolutely no decrease in effects from lithium unlike antipsychotics, i think it is important to balance the risks of going unmedicated. Given the half life may be 24 hours.
Id guess that 48 hours would be sufficient to see if it has a dramatic effect while keeping the time unmedicated to as low as possible.
Do you have people who can check up on you incase you develop manic or depressive or psychotic or whatever you are on this for.
Please be aware i would consider this extremely high risk and i would especially be on the lookout for suicidal thoughts.
Also, i do not know if it is safe to discontinue lithium at once because ove never went off it.
Id guess that 48 hours would be sufficient to see if it has a dramatic effect while keeping the time unmedicated to as low as possible.
Do you have people who can check up on you incase you develop manic or depressive or psychotic or whatever you are on this for.
Please be aware i would consider this extremely high risk and i would especially be on the lookout for suicidal thoughts.
Also, i do not know if it is safe to discontinue lithium at once because ove never went off it.
Jekyl Anhydride
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Again D1nach raises some good points as extra support regarding discontinuation is wise decision.
This might help a little if cessation is a foregone conclusion, although I wouldn't make this decision lightly.
https://www.ncbi.nlm.nih.gov/pubmed/6882990 ~Withdrawal symptoms from lithium. Four case reports and a questionnaire study.
https://www.ncbi.nlm.nih.gov/pubmed/12404784 ~Short-term sequelae of lithium discontinuation
https://www.ncbi.nlm.nih.gov/pubmed/10073392 ~Effects of lithium treatment and its discontinuation on suicidal behavior in bipolar manic-depressive disorders.
https://www.ncbi.nlm.nih.gov/pubmed/8498879 ~Outcome after rapid vs gradual discontinuation of lithium treatment in bipolar disorders.~
This might help a little if cessation is a foregone conclusion, although I wouldn't make this decision lightly.
https://www.ncbi.nlm.nih.gov/pubmed/6882990 ~Withdrawal symptoms from lithium. Four case reports and a questionnaire study.
https://www.ncbi.nlm.nih.gov/pubmed/12404784 ~Short-term sequelae of lithium discontinuation
https://www.ncbi.nlm.nih.gov/pubmed/10073392 ~Effects of lithium treatment and its discontinuation on suicidal behavior in bipolar manic-depressive disorders.
https://www.ncbi.nlm.nih.gov/pubmed/8498879 ~Outcome after rapid vs gradual discontinuation of lithium treatment in bipolar disorders.~
Excellent links.
Basically, I am on lithium for a suicide attempt and since being on it i went from constant suicidal thoughts and a careful planned out suicide where i happened to fall stuck in a like weird split so i couldnt choke on my vomit. To zero suicidal thoughts in years. If your on it for a similarly severe reason I wouldnt stop it even for two days.
On a side note, Ive seen tons of people in outpatient just stop there meds and do some crazy stuff. Two days doesnt seem like long but you can really mess up your life in two days if you become unstable.
Basically, I am on lithium for a suicide attempt and since being on it i went from constant suicidal thoughts and a careful planned out suicide where i happened to fall stuck in a like weird split so i couldnt choke on my vomit. To zero suicidal thoughts in years. If your on it for a similarly severe reason I wouldnt stop it even for two days.
On a side note, Ive seen tons of people in outpatient just stop there meds and do some crazy stuff. Two days doesnt seem like long but you can really mess up your life in two days if you become unstable.
Thanks for your reply again and thabks heaps for your concern! I see a psychiatrist once a week to manage medication etc, but I will definitely not take this lightly and will put alot of consideration into it thanks for your help and care means alot
Thanks heaps jekl will definitely not take this lightly and will put consideration into it you're help is very appreciated thankyou!
So much this. Never forget that mental stability is often a slippery slope.
People think they're going to do a bar of xanax, but by the time the alprazolam hits them, they're so disinhibited that they see no reason not to do another one. And after the third xanax, they're probably no longer aware how much they've had already, so they end up going through their stash in a single night.
Likewise, someone going off mood stabilizers or antipsychotics for a few days might be rebounding into mania, and decide not to go back onto their meds because mania feels kinda good, man, and by the fifth day they're convinced that their meds were part of a repto-zionist plot to suppress their divine Jesus-ichor.
I tried giving it a shot after 5 days without lithium and still nothing. The last thing I can rule out is maybe the antipsychotics I was on for about 4 months earlier this year? I've been off them for months now but is there a chance they made a semi permonant change on dopamine or something?