I take roughly 10 to 12 grams of Kratom at a time. The effect is subtle, and sometimes not noticeable. I've tried dosages ranging from around 2 grams up to around 30 grams. Even at 20 to 30 grams I could barely notice anything other than feeling nauseated. And I didn't take anything higher than 30 grams since that's pretty much a guaranteed stomach upset. As for opioids, for a few months I took small amounts of dope. Around 5 to 10 days out of each month, and about one bag to a max of about 5 bags per day, and never more than 2 bags at a time. Though there were only a few days that I had taken 5 bags. The other days it was fewer than 5. So, I think that's the equivalent of 100mg to 500mg per day on the days I've done it. I've taken oxy's too, but only about 7mg to 15mg at a time (a half or one whole 15mg tablet), and only about once every couple months, for a few years. In the past couple years though I haven't taken anything as far as opioids.