Question About GABA & CRH

[trainman04]

This study: https://www.ncbi.nlm.nih.gov/pubmed/10723009
''mRNAs for the alpha1 and beta2 subunits of the GABA(A) receptor were detected within 53.3% and 65.7% of PVN CRH neurons, respectively.''

Then this study: https://www.ncbi.nlm.nih.gov/pubmed/12480126
''Self-inhibition of GABA cannot stop all transport into the brain, and the highest recorded value of inhibition has been 80%''

If someone takes say an GABA-A agonist like Xanax, how much CRH inhibition will there be? 53,3%, 65%,7 or 80%?
Like how much inhibition can GABA on its own have? Is there a limit or can GABA inhibit 100% of the CRH?
Lets say GABA inhibits 80% and I take a supplement called St John's wort which has been shown to reduce CRH by 20% ( https://www.ncbi.nlm.nih.gov/pubmed/11526469 ), would that mean taken together it would be 100% inhibition?
At the moment im looking at a hormone called 5a-dhp that is a precursor to allopregnanolone which is an GABA-A modulator, im curious how much it will help with blocking CRH, (cortisol releasing hormone) if it is only 80% since that is only as much as your BBB (blood brain barrier) allows? And if so would combining it with St John's wort increase it from 80% to 100% so you are at a constant normal CRH base.
Also make it clear it is the hypericin content not Hyperforin that decreases CRH:https://www.ncbi.nlm.nih.gov/pubmed/12865894

I hope this made sense... im not looking for medical advice im just curious how much CRH GABA can be allowed to block.

 

[Limpet_Chicken]

You do NOT want to fully block CRF/CRH, This will cause loss of corticosteroid biosynthesis and put you in hospital in an adrenal crisis.

 

[trainman04]

You do NOT want to fully block CRF/CRH, This will cause loss of corticosteroid biosynthesis and put you in hospital in an adrenal crisis.

not fully block but just normal base. crh is not always active it is only active during stress right?

So say someone has an crh-secreting tumour, then he would need 100% block in order for his body to return to normal base right
im just curious how much GABA , gaba-a specfically blocks CRH, and what would happen if you combine it with st johns wort which has been shown to reduce crh by 20%. so what numbers are we talking?

 

[sekio]

crh is not always active it is only active during stress right?

CRH is active all the time, just like your adrenergic system. You need some baseline level of cortisol just to be functional.
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[trainman04]

CRH is active all the time, just like your adrenergic system. You need some baseline level of cortisol just to be functional.
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thats what i figured. so a crh/crf1 tumor would just mean the person has higher crh activity than normal.

that goes back to my original question, how much crh would GABA-A inhibit and combined with st johns wort. both have long half lives (st johns has life 26 hours and 5a-dhp i think has 40+ hours) so it should be an constant effect inhibiting crh. like im curious how much the brain allows GABA-A to act on the crh activity. I also wonder does GABA-A inhibit CRF1 also or just CRH? cause CRF1 is what im curious about. if i had to guess all 3 since gaba-A is inhibitatory . but then I wonder where GABA-B comes in.

its funny it is better to have CRF1 decreased and CRF2 increased but CRH decreased according to selfdecode.
https://www.selfdecode.com/gene/crhr1/
https://www.selfdecode.com/gene/crhr2/
https://www.selfdecode.com/gene/crh/