Limpet_Chicken
Bluelighter
- Joined
- Oct 13, 2005
- Messages
- 6,323
Here is an individual report, plus a summary of my quite extensive experience of the seemingly rather scarce, but most excellent GABAergic downer, chlormethiazole.
This particular day, chlormethiazole was taken as a mixture, as I'm also a chronic pain patient so I take morphine and oxy daily, I also have a script for chlormethiazole, which I was lucky enough to get on an off-label basis, although unlicensed for this use, in the UK, for my seizure control med, a job it does wonderfully, decided to use it recreationally today as well, which i do occasionally, just means I'll need to get a 'rescue pack', some additional caps, which I get from time to time as needed, later in the week.
After a bit of a rough night, as it was the night on which my last rx ran out, and I needed to wait until morning to get my refill from the docs, basically dealt with that with the help of a little dihydrocodeine, a bottle of cherry wine, some dextromethorphan, as a large bottle of robitussin dry cough mixture, and drowned my insomnia in a liter of Lamb's navy dark rum.
Did get some sleep, in the end though despite my large opioid tolerance. Awoke with a bit of a hangover, so, decided I'd take a solid recreational dose of a few of my meds.
Chlormethiazole 9 of the 192mg 'heminevrin' caps, these come as thick-walled, greyish colored eggs, containing 192mg chlormethiazole base per 'egg'. Packs quite a punch, its one of the few remaining GABAergic depressants of the old school, the real wallbangers that mostly got canned for abuse potential. 'ludes, barbiturates, ethchlorvynol and the like. I suspect, that the reason chlormethiazole is still with us and at least in the UK, allowed to be given on an outpatient basis, is that it can be used for alcohol detox, its not only a GABAa agonist, but an alcohol dehydrogenase inhibitor, which means that it slows the metabolic clearance of alcohol, so there isn't such an abrupt drop when a patient first starts replacement and taper therapy, to help avoid DTs, seizure etc.
I don't take it for alcoholism, because I'm not, and never have been, probably never will be, an alcoholic. I don't really drink much, last night was the only time, bar two shots, maybe three, over several days, given me by my father, who offered to share a few tots of a bottle of rum I got him for his birthday a while back. Bought a bottle of dark rum myself the other night, plus the cherry wine, but otherwise, I've not had any booze in months and months.
This also makes it exceedingly dangerous a drug, over and above other depressants, to combine with alcohol. Its killed a fair lot of people. Including Keith Moon, from the band The Who. I take it for seizure prevention and for thwarting breakthrough seizures of a mixed, biphasic myoclonic turning to atonic type. It works very quickly, once the eggs break open after swallowing, it can bring me out of an attack within a matter of minutes.
In terms of its action upon the brain, it rather resembles the barbiturates, in its effect upon GABAa receptors, rather than benzos, Z-drugs or orthosteric agonists like muscimol. Both reducing desensitization upon activation, and prolonging and intensifying the amplitude of the chloride flux, making GABAa chloride channels open more frequently also. Although chlormethiazole, unlike the barbiturates, does not also possess the effect of a negative allosteric modulator of AMPA type ionotropic glutamate receptors.
Initially, three 192mg heminevrin eggs were taken just after receiving the package of medications from the pharmacy, two different morphine formulations, one of oxy IR, chlormethiazole, tizanidine, clonidine, nitrazepam, cimetidine and a number of other meds, mostly intended for my stomach, I've had some stomach problems in the past so theres a fair few other meds I get for that, like gaviscon, buscopan, ondansetron, cimetidine and others.
Then of course, I was needing my morning opiate dose, so I whipped up a shot of 180mg morphine sulfate and slammed it IM. Followed by railing initially 70mg of oxycodone, and over the day topping up here and there with 20-30mg doses of oxy at a time, until 180mg or so had gone up the ol' face hoover, topping up with a few more doses of chlormethiazole, until 9 caps had been taken, and a couple of cimetidine pills taken with my first morphine shot to lessen metabolic destruction of the opiatey goodness.
Started to feel the morphine and oxy first, with the shakes and overheating dissipating, to be soon replaced, over a couple of minutes with a nice relaxing warm glow, as my headache just evaporated into the aether, followed by the warming burn of the chlormethiazole running down my throat, and its characteristic scent and taste every time I belched for a while later, tastes like a mixture of somewhat overripe apples, with ethereal, slightly metallic and minty overtones, somewhat of a tingling sensation produced behind the back of the bridge of the nose, right at the top, due to its histamine releasing properties.
Within minutes, I began to feel the first onset, maybe 5 minutes or so, after the three heminevrin caps had begun to do their delightfully wall-banger duty with flying colours, as my nose started to tingle, then my muscles started going all floppy and the nagging sore ache in the small of my back faded and soon vanished. Eyelids exhibiting ptosis, drooping at the corners. Decided to top up after a few hours with another pair of capsules and a couple more lines of oxy. Slept off that hangover and awoke feeling refreshed and full of energy. I find chlormethiazole leaves me very clear headed afterwards, and I can still work on it, if I need to go and work in the lab, and as a bonus, even though I take it at a minumum, every day, three times a day, I've never developed a tolerance, to any more extent than being accustomed to taking it and able to manage it safely at higher doses, as well as safely knowing my limits with pain meds in combination and NO physical dependency, even the least bit, not even from a good number of years taking the stuff.
Got to be my favourite GABAa agonist downer, a wall-banger that even doctors tend to look a bit surprised at my being on, telling me its old-school wall-banger fodder and rarely used these days, but it doesn't have the stigma of benzos, stupidly enough, just because its chemically unrelated to the barbs and benzos, it doesn't seem to have the same stigma, don't get treated like a fucking criminal for being on it etc. Much more dangerous in overdose, as the barbs are, but chemically unique in its class, as used in medicine. Plus easy to synthesize if needs be
Pretty nasty stuff, but soluble in H2O. Smells funky, but pleasant, although it has to be stored in glass bottles, as it eats plastics, and I don't want to be wasting the chemically resistant storage bottles with teflon caps and seals, and teflon-wrapped threads for something that doesn't need the full hazmat treatment, those are needed for keeping the likes of my iodine monochloride, bromine, SOCl2, chromyl chloride and other such nasties.I don't have enough of them to waste them, need to buy more (bottles for eat your face off nasties, that is, I'm neck deep in eat your face off nasties themselves![:\](https://bluelight.org/xf/BL_Images/Orig_Emoji/wrygrin.gif "wry grin :\")
)
Later on in the day, decided a couple more times to neck another 2 or three caps here and there, top up with occasional lines of oxy, until I'd done 170mg oxy in total, plus a second shot of morphine, bringing the total to 300mg/shot and 800mg cimetidine with each, as a potentiator, and to interrupt metabolism of the sulfate of morphia as far as practical. Although about to go pack some grapefruit juice down (LOVE that stuff
), and take a dose of DXM cough syrup for tolerance reduction and potentiation purposes. Nothing too heavy, just a gulp or two of robitussin, as its action as an NMDA receptor antagonist helps keep my opiate tolerance as low as I can, until I can get more memantine.
Still feeling nicely buzzed, although going to go top off on the morphine, lazing around as a boneless heap on the sofa, watching 'plebs' on the box, and playing fallout-tactics (going well, up against super-mutants atm, just captured quite a nice load of loot, including a flamethrower, a pistol-sized flamethrower sidearm as well, several .50 cal browning M2 autocannons, several sniper rifles, a couple of rocket launchers and one fucking huge stash of 7.62mm machineguns, and a full squad, armed to the teeth with everything from pistols and assault rifles to sniper rifles, autocannon, machineguns, plasma grenades, combat auto-shotguns and rocket launchers, lazily, buzzing my tits off as I leave a trail of blood and corpses in my wake.
Mmm...time for another line of oxy and to go blow a few eyeballs out and shoot a few dicks off (its hilarious, the fallout series of games allows one to target specific bodyparts with aimed shots, for crippling effects, and drops some funny one liners at the likes of a critical hit to the privates with a shotgun or sniper rifle)
Tagged by Xorkoth
substancecode_chlormethiazole
substancecode_gabaergics
substancecode_morphine
substancecode_opiates
substancecode_oxycodone
substancecode_opiates
substancecode_cimetidine
substancecode_tagamet
_combo_
explevel_experienced
exptype_positive
exptype_glowing
roacode_oral
roacode_nasal
roacode_im
This particular day, chlormethiazole was taken as a mixture, as I'm also a chronic pain patient so I take morphine and oxy daily, I also have a script for chlormethiazole, which I was lucky enough to get on an off-label basis, although unlicensed for this use, in the UK, for my seizure control med, a job it does wonderfully, decided to use it recreationally today as well, which i do occasionally, just means I'll need to get a 'rescue pack', some additional caps, which I get from time to time as needed, later in the week.
After a bit of a rough night, as it was the night on which my last rx ran out, and I needed to wait until morning to get my refill from the docs, basically dealt with that with the help of a little dihydrocodeine, a bottle of cherry wine, some dextromethorphan, as a large bottle of robitussin dry cough mixture, and drowned my insomnia in a liter of Lamb's navy dark rum.
Did get some sleep, in the end though despite my large opioid tolerance. Awoke with a bit of a hangover, so, decided I'd take a solid recreational dose of a few of my meds.
Chlormethiazole 9 of the 192mg 'heminevrin' caps, these come as thick-walled, greyish colored eggs, containing 192mg chlormethiazole base per 'egg'. Packs quite a punch, its one of the few remaining GABAergic depressants of the old school, the real wallbangers that mostly got canned for abuse potential. 'ludes, barbiturates, ethchlorvynol and the like. I suspect, that the reason chlormethiazole is still with us and at least in the UK, allowed to be given on an outpatient basis, is that it can be used for alcohol detox, its not only a GABAa agonist, but an alcohol dehydrogenase inhibitor, which means that it slows the metabolic clearance of alcohol, so there isn't such an abrupt drop when a patient first starts replacement and taper therapy, to help avoid DTs, seizure etc.
I don't take it for alcoholism, because I'm not, and never have been, probably never will be, an alcoholic. I don't really drink much, last night was the only time, bar two shots, maybe three, over several days, given me by my father, who offered to share a few tots of a bottle of rum I got him for his birthday a while back. Bought a bottle of dark rum myself the other night, plus the cherry wine, but otherwise, I've not had any booze in months and months.
This also makes it exceedingly dangerous a drug, over and above other depressants, to combine with alcohol. Its killed a fair lot of people. Including Keith Moon, from the band The Who. I take it for seizure prevention and for thwarting breakthrough seizures of a mixed, biphasic myoclonic turning to atonic type. It works very quickly, once the eggs break open after swallowing, it can bring me out of an attack within a matter of minutes.
In terms of its action upon the brain, it rather resembles the barbiturates, in its effect upon GABAa receptors, rather than benzos, Z-drugs or orthosteric agonists like muscimol. Both reducing desensitization upon activation, and prolonging and intensifying the amplitude of the chloride flux, making GABAa chloride channels open more frequently also. Although chlormethiazole, unlike the barbiturates, does not also possess the effect of a negative allosteric modulator of AMPA type ionotropic glutamate receptors.
Initially, three 192mg heminevrin eggs were taken just after receiving the package of medications from the pharmacy, two different morphine formulations, one of oxy IR, chlormethiazole, tizanidine, clonidine, nitrazepam, cimetidine and a number of other meds, mostly intended for my stomach, I've had some stomach problems in the past so theres a fair few other meds I get for that, like gaviscon, buscopan, ondansetron, cimetidine and others.
Then of course, I was needing my morning opiate dose, so I whipped up a shot of 180mg morphine sulfate and slammed it IM. Followed by railing initially 70mg of oxycodone, and over the day topping up here and there with 20-30mg doses of oxy at a time, until 180mg or so had gone up the ol' face hoover, topping up with a few more doses of chlormethiazole, until 9 caps had been taken, and a couple of cimetidine pills taken with my first morphine shot to lessen metabolic destruction of the opiatey goodness.
Started to feel the morphine and oxy first, with the shakes and overheating dissipating, to be soon replaced, over a couple of minutes with a nice relaxing warm glow, as my headache just evaporated into the aether, followed by the warming burn of the chlormethiazole running down my throat, and its characteristic scent and taste every time I belched for a while later, tastes like a mixture of somewhat overripe apples, with ethereal, slightly metallic and minty overtones, somewhat of a tingling sensation produced behind the back of the bridge of the nose, right at the top, due to its histamine releasing properties.
Within minutes, I began to feel the first onset, maybe 5 minutes or so, after the three heminevrin caps had begun to do their delightfully wall-banger duty with flying colours, as my nose started to tingle, then my muscles started going all floppy and the nagging sore ache in the small of my back faded and soon vanished. Eyelids exhibiting ptosis, drooping at the corners. Decided to top up after a few hours with another pair of capsules and a couple more lines of oxy. Slept off that hangover and awoke feeling refreshed and full of energy. I find chlormethiazole leaves me very clear headed afterwards, and I can still work on it, if I need to go and work in the lab, and as a bonus, even though I take it at a minumum, every day, three times a day, I've never developed a tolerance, to any more extent than being accustomed to taking it and able to manage it safely at higher doses, as well as safely knowing my limits with pain meds in combination and NO physical dependency, even the least bit, not even from a good number of years taking the stuff.
Got to be my favourite GABAa agonist downer, a wall-banger that even doctors tend to look a bit surprised at my being on, telling me its old-school wall-banger fodder and rarely used these days, but it doesn't have the stigma of benzos, stupidly enough, just because its chemically unrelated to the barbs and benzos, it doesn't seem to have the same stigma, don't get treated like a fucking criminal for being on it etc. Much more dangerous in overdose, as the barbs are, but chemically unique in its class, as used in medicine. Plus easy to synthesize if needs be
Pretty nasty stuff, but soluble in H2O. Smells funky, but pleasant, although it has to be stored in glass bottles, as it eats plastics, and I don't want to be wasting the chemically resistant storage bottles with teflon caps and seals, and teflon-wrapped threads for something that doesn't need the full hazmat treatment, those are needed for keeping the likes of my iodine monochloride, bromine, SOCl2, chromyl chloride and other such nasties.I don't have enough of them to waste them, need to buy more (bottles for eat your face off nasties, that is, I'm neck deep in eat your face off nasties themselves
)Later on in the day, decided a couple more times to neck another 2 or three caps here and there, top up with occasional lines of oxy, until I'd done 170mg oxy in total, plus a second shot of morphine, bringing the total to 300mg/shot and 800mg cimetidine with each, as a potentiator, and to interrupt metabolism of the sulfate of morphia as far as practical. Although about to go pack some grapefruit juice down (LOVE that stuff
), and take a dose of DXM cough syrup for tolerance reduction and potentiation purposes. Nothing too heavy, just a gulp or two of robitussin, as its action as an NMDA receptor antagonist helps keep my opiate tolerance as low as I can, until I can get more memantine.Still feeling nicely buzzed, although going to go top off on the morphine, lazing around as a boneless heap on the sofa, watching 'plebs' on the box, and playing fallout-tactics (going well, up against super-mutants atm, just captured quite a nice load of loot, including a flamethrower, a pistol-sized flamethrower sidearm as well, several .50 cal browning M2 autocannons, several sniper rifles, a couple of rocket launchers and one fucking huge stash of 7.62mm machineguns, and a full squad, armed to the teeth with everything from pistols and assault rifles to sniper rifles, autocannon, machineguns, plasma grenades, combat auto-shotguns and rocket launchers, lazily, buzzing my tits off as I leave a trail of blood and corpses in my wake.
Mmm...time for another line of oxy and to go blow a few eyeballs out and shoot a few dicks off (its hilarious, the fallout series of games allows one to target specific bodyparts with aimed shots, for crippling effects, and drops some funny one liners at the likes of a critical hit to the privates with a shotgun or sniper rifle
)Tagged by Xorkoth
substancecode_chlormethiazole
substancecode_gabaergics
substancecode_morphine
substancecode_opiates
substancecode_oxycodone
substancecode_opiates
substancecode_cimetidine
substancecode_tagamet
_combo_
explevel_experienced
exptype_positive
exptype_glowing
roacode_oral
roacode_nasal
roacode_im
Last edited by a moderator:
But I really think you should work on not feeling like you do about yourself and life. If for no other reason at first, just because, fuck them, don't let them win. But really, you should do it for you, because although the world sucks, it's also amazing. Life is beauty and ugliness, pain and pleasure. Sometimes it's really hard. But when you realize and focus on what is good about yourself, rather than what you perceive as bad, slowly your perception shifts. And once you don't feel awful about yourself, everything else starts to look better.