novaveritas
Bluelighter
- Joined
- Jun 8, 2018
- Messages
- 991
These were developed in the 1950s, with analgesics and the neuroleptics it was SAR If you think it was QSAR then give the reference of the paper with the relevant math.No, QSAR.
N&PD Moderators: Skorpio | thegreenhand
These were developed in the 1950s, with analgesics and the neuroleptics it was SAR If you think it was QSAR then give the reference of the paper with the relevant math.No, QSAR.
I think the advantage of fentanyl and its friends is that it's easily accessible by total synthesis. Etorphine and other morphinans need a source of the quadricyclic precursor somehow, be it thebaine, morphine, codeine etc.
Even things like racemorphan are less economical than fentanyl when you look at the complexity of synthesis. I'd imagine the hard part of carfentanyl synthesis is just making the 4-carboxy-4-amino-piperidine nucleus.
Carfentanyl is easily made with Ugi reaction, but like all fentanyls it is shit. Bentley compounds, oripavine derivatives are much more interesting, historically its a huge shame that Janssen demonized the oripavines for medicine in favor of fentanyl, Thats Business Bullshit, Belgian style.
Demonized? how so? and from my experience with a few of the fentanyls, I'd far sooner, if I were going to be doing any ultrapotent opioid, try one of the oripavines, etorphine, dihydroetorphine etc. than the likes of carfentanil.
Any guesses why fentanyls are not as euphoric as the fused-ring opioids? Maybe a bound fentanyl molecule dissociates from the mu receptor so slowly that the receptors become desensitized... Or then there are more subtypes of mu receptor than is currently known. Or you also need some amount of delta affinity to cause euphoria.
Even if one batch in 10 contains something really toxic like WP, it's going to cause a lot of damage...
The extraction of morphine-like alkaloids may not work in the same way as with amphetamines, as they are also soluble to alkaline solutions because of the phenol -OH, and it seems that morphine freebase is not soluble to petroleum ether (but is soluble to some other nonpolar solvents). Maybe it's some misunderstanding about how it should be purified by extraction.
Actually, looking at solubility data, codeine freebase isn't soluble in pet ether either, and I think that must have been the real reason why my own codeine extraction didn't do the trick as I expected...