Neuroprotection
Bluelighter
- Joined
- Apr 18, 2015
- Messages
- 1,088
Because this post is so long, I have put my questions at the beginning incase people get deterred by the background information.
1 ? What is the current status of Fatostatin? Does anyone think it will be approved soon?
2 ? Why have fatty Acid Synthase inhibitors not been seriously considered for obesity, apart from metabolic syndrome. All studies I have read which do consider it, blatantly ignore impacts on body weight, some saying it is not very important. How stupid!?
3 How usefull, and what are the potential consequence?s of using non selective ACC inhibitors in humans to block weight gain.
4 although long term use of any one of the drugs mentioned above is unadvisable given their interference with metabolism, could they be diploid in times of huge junk food binges to prevent dramatic fat gain?
Although there is controversy surrounding the extent to and process by which Carbohydrates are converted to fat it is undeniable that eating carbs in excess will cause fat gain. The process is called DE novo lipogenesis. Some highly regarded scientific studies try to claim the modern day obesity crisis is not due to this process but rather, a high carb and high fat combination as occurs in processed food cause the body to stor dietary fat as it prefers to use carbs for energy. It is argued that a high Carb very low fat diat alone giving equivalent calories would not lead to the same fat gain. I am now curious about what such findings mean for the average person. Could it partly explain why, I remained under weight as a child despite consume massive amounts of sugar in the form of sweets, fizzy drinks/energy drinks, 4/8 spoons of sugar in tea and around 8 slices of toast with excess huny for breakfast. Interestingly I used to hate fatty foods e.g. read meat, butter, cheese and other greasy foods. However, I still believe, as do most experts, no matter how inefficient de novo lipogenesis, in the long term it is a massively important factor in weight gain.
1 ? What is the current status of Fatostatin? Does anyone think it will be approved soon?
2 ? Why have fatty Acid Synthase inhibitors not been seriously considered for obesity, apart from metabolic syndrome. All studies I have read which do consider it, blatantly ignore impacts on body weight, some saying it is not very important. How stupid!?
3 How usefull, and what are the potential consequence?s of using non selective ACC inhibitors in humans to block weight gain.
4 although long term use of any one of the drugs mentioned above is unadvisable given their interference with metabolism, could they be diploid in times of huge junk food binges to prevent dramatic fat gain?
Although there is controversy surrounding the extent to and process by which Carbohydrates are converted to fat it is undeniable that eating carbs in excess will cause fat gain. The process is called DE novo lipogenesis. Some highly regarded scientific studies try to claim the modern day obesity crisis is not due to this process but rather, a high carb and high fat combination as occurs in processed food cause the body to stor dietary fat as it prefers to use carbs for energy. It is argued that a high Carb very low fat diat alone giving equivalent calories would not lead to the same fat gain. I am now curious about what such findings mean for the average person. Could it partly explain why, I remained under weight as a child despite consume massive amounts of sugar in the form of sweets, fizzy drinks/energy drinks, 4/8 spoons of sugar in tea and around 8 slices of toast with excess huny for breakfast. Interestingly I used to hate fatty foods e.g. read meat, butter, cheese and other greasy foods. However, I still believe, as do most experts, no matter how inefficient de novo lipogenesis, in the long term it is a massively important factor in weight gain.