Doclad
Bluelighter
- Joined
- Mar 17, 2015
- Messages
- 415
Hello everyone.
When it comes to taking stimulants that require low doses (amphetamine, hex-en and isopropylphenidate mostly) I like to do it by nasal route. The fact is that I use a nebulizer to reduce the damage caused to thenasal mucous and improve the bioavailability of the medication by segregating it evenly over the entire surface.
What I've not managed to avoid is pain. It hurts less than directly snorted, but it still hurts a lot. I have used distilled water solutions with Lidocaine HCl (20mg) to counteract this side effect but it does not do much for me, and it numbs my throat and I do not like it.
I think I read somewhere that osmolarity can play an important role in all this. I understand that it has to do with the osmotic pressure in the cells of the mucous membrane and the physical properties of the substances, and that add the right amount of NaCl to the solution can markedly reduce the pain. Is there any way to know if the pain is due to osmotic pressure or is it due to the causticity of the substance? If someone can explain this fact more deeply I would be very grateful.
Definitely, I would like to know what amount of NaCl I need to add to my solutions of 20mg/ml of Amphetamine, HEX-EN and Isopropylphenidate respectively, and if this balance can guarantee the reduction of pain in any case.
If someone can throw some formula for the calculation it would be great.
(Perhaps the thread fits better in the sub-forum "Neuroscience and Pharmacology Discussion". Put it there if you think it necessary, please).
DocLad
When it comes to taking stimulants that require low doses (amphetamine, hex-en and isopropylphenidate mostly) I like to do it by nasal route. The fact is that I use a nebulizer to reduce the damage caused to thenasal mucous and improve the bioavailability of the medication by segregating it evenly over the entire surface.
What I've not managed to avoid is pain. It hurts less than directly snorted, but it still hurts a lot. I have used distilled water solutions with Lidocaine HCl (20mg) to counteract this side effect but it does not do much for me, and it numbs my throat and I do not like it.
I think I read somewhere that osmolarity can play an important role in all this. I understand that it has to do with the osmotic pressure in the cells of the mucous membrane and the physical properties of the substances, and that add the right amount of NaCl to the solution can markedly reduce the pain. Is there any way to know if the pain is due to osmotic pressure or is it due to the causticity of the substance? If someone can explain this fact more deeply I would be very grateful.
Definitely, I would like to know what amount of NaCl I need to add to my solutions of 20mg/ml of Amphetamine, HEX-EN and Isopropylphenidate respectively, and if this balance can guarantee the reduction of pain in any case.
If someone can throw some formula for the calculation it would be great.
(Perhaps the thread fits better in the sub-forum "Neuroscience and Pharmacology Discussion". Put it there if you think it necessary, please).
DocLad
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