i are spectre
Bluelighter
- Joined
- Dec 23, 2000
- Messages
- 1,201
"Ibogaine, the prototypic iboga alkaloid that is utilized clinically to treat addictions, has been associated with QT prolongation, torsades de pointes, and fatalities... In view of the extended half-life of noribogaine, these results may relate to observations of persistent QT prolongation and cardiac arrhythmia at delayed intervals of days following ibogaine ingestion."
https://www.ncbi.nlm.nih.gov/pubmed/25636206
This is kind of the consensus when I browse through many recent articles about ibogaine and iboga alkaloids. Blocking hERG potassium channels in cardiac tissue delays action potentials, prolongs QT, and can ultimately lead to an arrhythmia.
Anyways, what can we do to reduce the risk of cardiac arrhythmia while taking these types of compounds? I have a few ideas...
Maintaining cardiovascular health (exercise, healthy diet, limit smoking/drinking, etc)
Abstain from compounds that prolong QT interval (i'm trying to put a list together of some more common substances here)
Adequate electrolyte intake, mainly potassium (I had litres of coconut water available prior to and during my ibogaine/iboga TA experience)
Maintaining adequate blood pressure via simple hydration (once again, the coconut water, loaded with potassium and other electrolytes)
Any other suggestions?
https://www.ncbi.nlm.nih.gov/pubmed/25636206
This is kind of the consensus when I browse through many recent articles about ibogaine and iboga alkaloids. Blocking hERG potassium channels in cardiac tissue delays action potentials, prolongs QT, and can ultimately lead to an arrhythmia.
Anyways, what can we do to reduce the risk of cardiac arrhythmia while taking these types of compounds? I have a few ideas...
Maintaining cardiovascular health (exercise, healthy diet, limit smoking/drinking, etc)
Abstain from compounds that prolong QT interval (i'm trying to put a list together of some more common substances here)
Adequate electrolyte intake, mainly potassium (I had litres of coconut water available prior to and during my ibogaine/iboga TA experience)
Maintaining adequate blood pressure via simple hydration (once again, the coconut water, loaded with potassium and other electrolytes)
Any other suggestions?