JohnBoy2000
Bluelighter
- Joined
- May 11, 2016
- Messages
- 2,463
Primarily what I'm thinking is, as stated in Stahls book - drugs with very minor NRI properties appear to exert quite noticeable NRI effects when applied in combination with SRI's.
However, NRI's in mono-therapy, require high dose, super high receptor occupancy, to exert clinically notable effects.
It seems that this may be relative to somewhat similar activation patterns in post synaptic protein phosphorylation, common to both serotonin and noradrenaline receptor agonism.
The outcome seemingly, one being considerably more efficacious in the presence of the other.
Relative to the title question - ADHD obviously responding to DA enhancement, or "tuning" of DA neurons, as the theory seems to go.
Obviously it responds to NA enhancement - prefrontal cortex, no DA transporters etc.
I use the example of ADHD, as it can be treated with NRI's - thus it's an easy way of highlighting my query.
Irregardless, the overall question is - if one were taking an NA agent in monotherapy like, Strattera, could one effectively make an SNRI out it, by applying say, Lexapro in combination therapy - thus avail of the "combination" effect on NA we see with SNRI's?
Is that principle sound?
Or are SNRI's entities onto themselves, with their own intrinsic properties can not be replicated by combining SSRI's and NRI's??
However, NRI's in mono-therapy, require high dose, super high receptor occupancy, to exert clinically notable effects.
It seems that this may be relative to somewhat similar activation patterns in post synaptic protein phosphorylation, common to both serotonin and noradrenaline receptor agonism.
The outcome seemingly, one being considerably more efficacious in the presence of the other.
Relative to the title question - ADHD obviously responding to DA enhancement, or "tuning" of DA neurons, as the theory seems to go.
Obviously it responds to NA enhancement - prefrontal cortex, no DA transporters etc.
I use the example of ADHD, as it can be treated with NRI's - thus it's an easy way of highlighting my query.
Irregardless, the overall question is - if one were taking an NA agent in monotherapy like, Strattera, could one effectively make an SNRI out it, by applying say, Lexapro in combination therapy - thus avail of the "combination" effect on NA we see with SNRI's?
Is that principle sound?
Or are SNRI's entities onto themselves, with their own intrinsic properties can not be replicated by combining SSRI's and NRI's??
