Is O-DSMT Freebase even slightly active intranasally?

[yeshello123]

I have a lot of this compound so "wasting" it is not really a concern of mine.

I'm willing to use nasal ROA if its active at all this way. I understand that given its low water solubility, it may not be; but have also read that certain freebase compounds which are lipophilic would be active nasally.

Looking for some more info on this topic.

 

[sekio]

Probably not, generally the nose and sinuses are too moist to effect absorption of freebases.

Some portion of insufflated compounds end up making their way to the stomach where the freebase would form a HCl salt so that may explain the paradoxical adsorption of some freebases.

 

[yeshello123]

Ok thanks a lot, won't waste my time on that ROA then.