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Opioids Question about maximum codeine use.

T

thatrandomdude

Bluelighter
Joined
Sep 2, 2017
Messages
70
Hello Bluelighters, I've tried to find info on this but not found anything solid. About codeine max use per day without wasting any that will be converted into morphine, I read that around 500mg is the most you could take that would be converted to morphine, the rest over that would just cause a histamine release. Does that mean not to take more than 500mg in 1 day? Or in 1 sitting?

I guess what i'm trying to find out is, if one took say 300mg at mid day, 12 - 1pm, then 300mg at 8pm, would the 300mg at 8pm still be converted into morphine or would only 200mg be?

Thanks and stay safe.
 
Math isn't that simple. Depends too much on your ROA and your genes, plus all the other drugs and food you eat.

One thing you don't need math for is to know that's too much codeine. 240mg spread out over the day, orally, is the max recommended.

It is not possible to get 100% conversion, no matter what you do. That's just biology.
 
500 isn't a magic number; half a gram is just a typical figure, not to go over, as a reasonable guidelines

You could take 300mg, then a quarter gram 8-12hours later, and it should convert just fine if you are a regular metabolizer

Use antihistamines with such codiene doses like Cetirizine, which is non-drowsy at low/recommended doses, however it is not a 2D inhibitor, like many 1st gen; diphenhydramine, effective first gen, however with daily use it is a 2Dinhibitor

and of course, careful CWE's-that is a lot of codiene; if it were pure, you could probably take it every 7-12 hours PRN
And remember CG, another active metabolite(to what degree?)
 
Over 500ng per day is a bit much, however if CYP enzymes can knock out opioids in 2-3 hours, there is no reason to think 12 hours later you couldn't redoes with codiene and get morphine-Yes it is quite complicated, however a quarter gram isn't a magic number-400mg is the ceiling effect for Ibuprofen, yet people insist on Motrin 800's, and woefully misinformed doctors tell you you are wrong when you point this out
 
What ROA? Doubt he is injecting into his muscles like Howard Hughes-pretty much that, or take it by mouth
It is worth noting that IM administration is 1.5-2x as potent as PO, despite people thinking you need first pass metabolism for morphine-you don't, it's pre-hepatic extraction and what not
 
Yeah I didn't think it would be simple maths but just wanted to try get as much info as I could since i'll be stuck with codeine for the next week or so instead of my usual DHC. The ROA will be orally in the cough syrup form (5ml - 15mg codeine)
I usually take around 600mg DHC throughout a day but i'm not hoping to really get a buzz off codeine - just to go without super bad WD's until I get my script.

And also yeah I have anti histamines, i'm prescribed promethazine to aid with sleep and it also aids with my opiate endeavours

Also I know 240mg is max recommended daily dose, I think it's around the same for DHC aswell, but I always end up taking 600mg sometimes more a day.
 
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Lorne is typing right now that DHC, while it does convert to dihydromorphine, does so in such small amounts that you should think of it as a pure DHC experience. Which doesn't excite even me.

I want to emphasize the difference between 240mg max. per day, and 300mg all at once: it is a big, uncomfortable one. The 240mg is qid. Also, try to keep your posts together.

ROA matters generally for those reactions, like if you shoot a bolus and saturate something vs. the ER slowly spewing its drug-laden PEG into your intestines.

ETA: he was telling you to skip those OG antihistamines if you're going for 100% morphine conversion, since they inhibit the enzyme you need. Promethazine is one of those.
 
Sorry the website edit function was being awkward and wouldn't let me edit my post. Yeah it doesn't exactly excite me much either but I've come down from Oxy to DHC, so i'm working my way slowly off them all together but i'm not quite ready to go through the WD's yet, hence why i'm stuck having to take codeine to stave off the WD's until I can get my script.. Since I take around 600mg DHC a day what would you recommend to dose with codeine to try keep WD's at bay? Thanks for your help too
 
^Merge my posts later

and shc becomes dihydroheroin-seriously, diadihydrocodionone - tricky stuff though

Yeah, you could take a gram of pure codiene per day(250mg qid) although, wouldn't recommend it

Theb again, you would probably need at least half a gram to make it worth it

200-300mg, PRN 2-3x per day seems, less uncomfortable

Wonder how much Howard Hughes injected into his muscles? Weird he would choose codiene, when morphine should have been plentiful then -Any thoughts?

Oh wait a question - sorry ��

Unfortunately you can't top half a gram of DHC with codiene; the max dose should stave wd, although as Scrofula said, it is stupid complicated for an opiate that isn't a big hitter

Try 300-400mg as a loading dose, and then, 7-12 hours later, take slightly less? Really, she is supposed to be 1.5-2x as potent as codiene, and you can't take a gram, or even a very large dose all at once-if your an extensive metabolizer it should work for a day or two, if your an ultra rapid metabolizer, your (somewhat) lucky, otherwise, it should help, to what degree????
Don't go over the max dose in one sitting, and get Cetirizine, because that is a lot of histamine - be careful
 
yeah I didn't expect to be able to get the same feeling as 600mg DHC as I know it's more potent, anyway, today is judgment day. First day without DHC in a long time, all I have is this damn codeine linctus cough syrup, I can already feel the pain in my legs, wd's starting to come in. I usually take 300mg as a starting dose for DHC, i'm not sure how big the histamine release is in codeine compared to DHC. I just don't want to go through the wd's... I have some anti histamnes (promethazine) and I won't be taking any of that until the codeine has fully taken effect.

Is 300mg a bit high of a starting dose? I don't want to just burn out into a huge histamine release, but at the same time I don't want to be fighting wd's straight for the next few days

edit: I will get some cetirizine from the local pharmacy. and I will be careful

edit 2: cetirizine is hella expensive, is there a cheaper alternative?
 
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Thanks that's pretty helpful. I took about 150mg and it is atleast holding the withdrawals at bay or so it seems for now. Is there a cheap alternative to any 2nd gen antihistamine? Cetirizine is extremely expensive. Would a pharmacy own brand do? Or are they 1st gen? Thanks for al your help guys.
 
it seems people have differing opinions on dosing, I do have a tolerance to DHC, (I usually dose 300mg at a time then another 300mg throughout the day) but i'm not sure if tolerance to DHC converts to tolerance to codeine
 
thatrandomdude said:
Thanks that's pretty helpful. I took about 150mg and it is atleast holding the withdrawals at bay or so it seems for now. Is there a cheap alternative to any 2nd gen antihistamine? Cetirizine is extremely expensive. Would a pharmacy own brand do? Or are they 1st gen? Thanks for al your help guys.
Click to expand...

Boots Hay Fever And Allergy Relief tablets are cetrrizine and aren't expensive at all...just a few quid for a box if 14..

For some bizzare reason (that makes no sense) you can't mention the price of an over the counter hayfever medication in this sub forum but Google it and you'll see what I mean
 
Backfromthebrink said:
Boots Hay Fever And Allergy Relief tablets are cetrrizine and aren't expensive at all...just a few quid for a box if 14..

For some bizzare reason (that makes no sense) you can't mention the price of an over the counter hayfever medication in this sub forum but Google it and you'll see what I mean
Click to expand...

Don't have a boots around here the only pharmacy we have is Lloyds and they only sell boxes of 21 which is like 500% more expensive than other retailers I've seen.

I'm not feeling too bad anyway I think I will have dosed about 200mg in the past 3 hours or so and not really had any histamine problems. How long is safe between doses, 5 or 6 hours?
 
thatrandomdude said:
Don't have a boots around here the only pharmacy we have is Lloyds and they only sell boxes of 21 which is like 500% more expensive than other retailers I've seen.

I'm not feeling too bad anyway I think I will have dosed about 200mg in the past 3 hours or so and not really had any histamine problems. How long is safe between doses, 5 or 6 hours?
Click to expand...

Do you have a Superdrug? They're even cheaper there...anywhere but Lloyds really...

I hate Lloyds...There's a Lloyds attached to my doctors and when I used to go in to pick up pain medication they always asked me to produce photo ID even though I'd been in hundreds of times before and they knew me by name...

I just used to refuse in principal just to piss them off lol.
 
thatrandomdude said:
Don't have a boots around here the only pharmacy we have is Lloyds and they only sell boxes of 21 which is like 500% more expensive than other retailers I've seen.

I'm not feeling too bad anyway I think I will have dosed about 200mg in the past 3 hours or so and not really had any histamine problems. How long is safe between doses, 5 or 6 hours?
Click to expand...

codeine is usually dosed 4 times a day so taking into account 8 hours when you're asleep, I'd say every 4 hours would he fine....4 - 6 hours really.
 
Backfromthebrink said:
Do you have a Superdrug? They're even cheaper there...anywhere but Lloyds really...

I hate Lloyds...There's a Lloyds attached to my doctors and when I used to go in to pick up pain medication they always asked me to produce photo ID even though I'd been in hundreds of times before and they knew me by name...

I just used to refuse in principal just to piss them off lol.
Click to expand...

Yeah they know me by face and name at my local one too but they still ask me stupid things when I go in even though they know what my prescription is since I pick it up every week, can't stand them.

The usual dose time is 4 hours I know, but that's when taking it 30-60mg at a time, not 200mg a time right?

The only reason i'm taking damn codeine is to try stave off wd's from DHC which it isn't doing a great job at but I don't want to take too much and have a histamine release.
 
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