trainman04
Bluelighter
- Joined
- Dec 18, 2017
- Messages
- 189
Hello. Can someone give me help me out.. I have so many genes for low functioning Cannabinoid System which I believe has lead to an enlarged amygdala.
SNP>
rs1049353 linked to the gene CNR1. Your genotype is TT, which is observed in 3% of all individuals reported.
rs7766029 CC 18%
rs806377 CC 26%
Then I got these Genes>
CRHR1 gene
Corticotrophin release hormone receptor 1 (CRHR1) is a receptor for the hormone CRH. Antalarmin blocks this receptor.
CRHR1 promotes anxiety in part by reducing cannabinoids in our amygdala. This happens when CRHR1 activation increases FAAH in the amygdala, which causes a reduction in the endocannabinoid anandamide (AEA).
Diseases associated with CRHR1 include generalized anxiety disorder, IBS, obesity and depression (R, R2). CRHcauses fear and anxiety (R, R2) via CRHR1 (R) and major depression (R)
CNR1
CB1 receptors are found in particularly high density in the hippocampus and amygdala.
It's better to have this gene increased most of the time.
Chronic stress in mice without CB1 receptors show an enlarged fear center or amygdala (dendrites) ?. In humans, regular cannabis use can effectively dampen activation of the amygdala in response to stressful conditions ?.
I believe all these Cannabinoid mutations added up and causing my anxiety . People usually just have 1 of these mutations but I got multipel... Please help how do I fix this ??
I made a list gathered from selfhacked site that I will try to increase my cannabinoid system
cb1
Galantamine
Butyrate
Tylenol
Kava
Genistein
EGCg
Honokiol
Fish oil/DHA
cb2
Echinacea
Diindolylmethane
Lactobacillus acidophilus
I just took some inositol low dose and Holy shit do I feel happy..... It increases Cannabinoid function. I was expecting less anxiety which I did get but I feel like I also took a dose of phenibut.
whats the half life of inositol anyone know?
also whats the d aspartic acid half life? I might just take d aspartic acid instead or pure NMDA.. Since the cannabinoid reduces fear/anxiety by activating the NMDA system I think. Because there is no effective way to increase the cannabinoid system or increase the amount of cannabinoid CB1/cb2 receptors.
And since low activity cannabinoid system is linked to enlarged amygdala and if I somehow fix it how long will it take for my enlarged amygdala to go back to normal size? is that possible?
SNP>
rs1049353 linked to the gene CNR1. Your genotype is TT, which is observed in 3% of all individuals reported.
- The T allele may cause lower CB1 receptor numbers and less CB1 activation, although this has not been experimentally confirmed (R).
- With this variation, the receptors also don't become significantly less sensitive when activated (R)
rs7766029 CC 18%
rs806377 CC 26%
Then I got these Genes>
CRHR1 gene
Corticotrophin release hormone receptor 1 (CRHR1) is a receptor for the hormone CRH. Antalarmin blocks this receptor.
CRHR1 promotes anxiety in part by reducing cannabinoids in our amygdala. This happens when CRHR1 activation increases FAAH in the amygdala, which causes a reduction in the endocannabinoid anandamide (AEA).
Diseases associated with CRHR1 include generalized anxiety disorder, IBS, obesity and depression (R, R2). CRHcauses fear and anxiety (R, R2) via CRHR1 (R) and major depression (R)
CNR1
CB1 receptors are found in particularly high density in the hippocampus and amygdala.
It's better to have this gene increased most of the time.
Chronic stress in mice without CB1 receptors show an enlarged fear center or amygdala (dendrites) ?. In humans, regular cannabis use can effectively dampen activation of the amygdala in response to stressful conditions ?.
I believe all these Cannabinoid mutations added up and causing my anxiety . People usually just have 1 of these mutations but I got multipel... Please help how do I fix this ??
I made a list gathered from selfhacked site that I will try to increase my cannabinoid system
cb1
Galantamine
Butyrate
Tylenol
Kava
Genistein
EGCg
Honokiol
Fish oil/DHA
cb2
Echinacea
Diindolylmethane
Lactobacillus acidophilus
I just took some inositol low dose and Holy shit do I feel happy..... It increases Cannabinoid function. I was expecting less anxiety which I did get but I feel like I also took a dose of phenibut.
whats the half life of inositol anyone know?
also whats the d aspartic acid half life? I might just take d aspartic acid instead or pure NMDA.. Since the cannabinoid reduces fear/anxiety by activating the NMDA system I think. Because there is no effective way to increase the cannabinoid system or increase the amount of cannabinoid CB1/cb2 receptors.
And since low activity cannabinoid system is linked to enlarged amygdala and if I somehow fix it how long will it take for my enlarged amygdala to go back to normal size? is that possible?