IIRC the binding affinity(Ki) is higher with the Suboxone's buprenorphine than Loperamide. For GI issues sure but if you're on centrally active amounts of Lope beware the induction phase or hit multiple small test doses that can be ridden out without full blown precips,
Loperamide has binding affinity similar to methadone, maybe between that and morphine
CNS activity is unlikely without inhibitors, because of low BA%, and PHP
However PWD's are certainly possible(at least in theory) if you are taking large doses of lope with proper co-medications to make it centrally active
Which would be borderline insane; at best your underwhelmed with significant yet transient and somewhat uncomfortable effects, at worst your crippled or otherwise changed for life (or it could be lethal at the extreme) even if not permanent, side effects abound
Doxlyamine is a good OTC anti-histamine to have around(Unisom classic sleeptabs and generic equivalents) and Cetirizine as an antihistamine and hit or miss anti-entic; it works, just requires larger doses to get into the CNS-like 30-40mg, though this may cause anticholinergic effects, main reason you avoid Benadryl (in general; if too nauseous, 25mg is still better than most US otc meds). Doxylamine has less side effects and is more relaxing, as a more potent sedative/hypnotic-12.5-25mgs is surprisingly active
In the U.K., GET Hydroxyzine; anti-emetic, mild anti-anxiety effects, fairly relaxing, and practically no anticholinergic activity, and side effects are rare, and it produces the long acting Cetirizine as a me/the primary metabolite; it just has multiple uses and IMO is worth a shot; Promethazine is a very good anti-emetic, literally among the best, and quite sedating, however it has anticholinergic effects that limit dosing, and also low, though variable BA%; note that you can take up to 100mg of hydroxyzine with 25-50mg (or 12.5 as a tester) as the starting dose, then another 25-50ng after gauging effect; BID is useful, except as hypnotic
Pronwthazine, you are kind of limited to 12.5-25mg, though it is still useful to have, if you don't have the non-anticholinergic hydroxyzine as an alternative
Gabapentin and other GABAergivs seem useful; and although no personal experience with phenibut, it is certainly worth trying, especially if gapapentin (or Pregabalin) helped, as sources tell me it helps as well, and is similiar in it's mechanism of action
Certain muscle relaxers, although flexeril has anti-cholinergic effects-too many RX meds to get into
Stay hydrated, that helps1and swriquel or remeron, also worth it, or Clonidine; RX only, though three then out there;
Plenty of resources outside of this thread, as already mentioned -Smooth Sailing
