N&PD Moderators: Skorpio | thegreenhand
where does it say block several dopamine receptors? its a partial agonist .Abilify is an antipsychotic. It will block several dopamine receptors, and only partially activate others.
Wellbutrin actually only has very weak effects on dopamine. Oh, it might bind to dopamine transporters in-vitro, but in-vivo (in the human body), it is rapidly converted to hydroxybupropion, which is still an effective noradrenaline reuptake inhibitor but almost devoid of dopaminergic activity.
where does it say block several dopamine receptors? its a partial agonist .
Wouldnt Ablify be a good way to increase Dopamine if your dopamine is low? In combination with wellbutrin. I thought it helped with balance more so increase dopamine than decrease it.,
but doesent partial agonist at the 5HT1A receptor decrease serotonin doesent it activate the autoreceptors ?I looked it up again: As far as serotonin receptors are concerned, Abilify is a partial agonist at 5HT1A and an antagonist at 5HT2A, 5HT2B and 5HT7. With dopamine it will selectively bind to D2, however there is evidence that rather than "partial agonism", its action might be best described as "functional selectivity" - it will act as an agonist where dopamine is too low, and an antagonist where dopamine is too high.
It's not really a "dopamine booster" except at neurons where dopamine is very low, as far as I know. There are cases where abilify has induced parkinsonism, so that would suggest that generally there is more blocking than activating going on on average.
It is certainly a drug worth trying, and it may very well help with your anxiety, just probably not in the way you think (i.e. it won't boost your dopamine to the point where it counteracts your serotonin, especially since it is also a partial agonist at the 5HT1A serotonin receptor).