wellbutrin + sertraline to block DAT efficiently

[sekio]

High dopamine you end up with less serotonin and other way around.

This is not how the brain works, but if you want to tunnel-vision on this topic, have fun abusing stimulants. It won't make you feel any better in the long run.

 

[Cotcha Yankinov]

Besides, if you were truly dopamine deficient, you'd have severe movement disorders and presentation of Parkinsons symptoms.

And he would not have been helped by Zyprexa/Olanzapine

 

[trainman04]

And he would not have been helped by Zyprexa/Olanzapine

i probably wasnt now that i think about it , zyprexa blocks many histamine receptors which probs made me tired and made me think it worked

 

[Cotcha Yankinov]

By that logic other drugs with strong antihistamine properties should have been helpful, and numerous drugs have strong antihistamine properties

 

[polymath]

I'd like to see a study where rats/mice with a SERT knockout mutation were given a chance to self-administer megadoses of sertraline... My guess is that even then it would not be necessarily positive reinforcing, as all dopamine reuptake inhibitors don't have same kind of "functional selectivity". By the way, a mutation that deletes the serotonin transporters isn't lethal at all - apparently the animals develop a tolerance to most of the effects of their excess serotonin early in development.