Heh in my case actually I might be in a position to rule it out. I have plenty ondansetron. And obviously, plenty access to off the shelf or clean EtOH (seriously, I don't get how people can STAND drinking, beer, etc. fine, but when it comes to spirits, I need it to be down in one swallow, or its going to come back up again seconds later. Hell I HAVEN'T had any alcohol, and all I did then was THINK of the smell of EtOH or (not that I'd drink it) iPA, and I just gagged reflexively. Its awful, that stink.
I don't RECALL any difference with alcohol whilst taking ondansetron, and indeed probably have used it as a primer, in order to be able to get the filthy stuff down and keep it there (its just one of those things...I've probably got weird tastes. I could LIKE the smell of gone-off SOCl2, almost (but not quite) but if it comes to booze...if I can smell it, I don't very much want to drink it.
80% or so and a one-shot dose is about the only way my insides will tolerate it. How strong, out of curiosity IS the the 5HT3 agonism from EtOH, and again, out of curiosity, is this lacking in diethyl or diisopropyl ether? I don't get the nasty ass brain zap type stuff with either.