Limpet_Chicken
Bluelighter
- Joined
- Oct 13, 2005
- Messages
- 6,323
In the hundred mg range? at a few hundred mg...better pack a suitcase. And cold, clinical, thats how I'd describe it. Not so much as the reports of the like of MK-801/dizocilpine (now thats been on my to try list for WAY too long, or some competitive antagonists of NMDARs.) but its got an icy kinda feel to it.
Edit-isn't the rapid antidepressant effect independent at least of dissociative effects? last I heard some pharm companies had rapid acting glutamatergic antidepressants in testing, I see rapastinel and similar glycine site partial agonist or mixed glycine site agonist/NMDA antagonist drugs are in testing, and indeed in the case of rapastinel seemingly past phase II and getting fast-tracked in the US.
Edit-isn't the rapid antidepressant effect independent at least of dissociative effects? last I heard some pharm companies had rapid acting glutamatergic antidepressants in testing, I see rapastinel and similar glycine site partial agonist or mixed glycine site agonist/NMDA antagonist drugs are in testing, and indeed in the case of rapastinel seemingly past phase II and getting fast-tracked in the US.
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