Thymosin β4 and cardiac repair

R

RedRum OG

Bluelighter
Joined
Jul 18, 2009
Messages
3,693
https://www.ncbi.nlm.nih.gov/pubmed/20536454


So this could be amazing for mankind in general but of course I'm thinking about us AAS users. This article was more about healing after heart attack, dealing with cell death. However as cardiac risks are (to me) one of the most serious things to worry about with AAS use, this could potentially minimize those risks and the anxiety accompanying them. Of course one the biggest issues for us is cardiac hypertrophy, for which this would probably do nothing, but some of the other issues could potentially be minimized or reversed. At the very least TB500 could somehow be used as a prophylactic of sorts.


Maybe this is old news to you guys but it blew my mind so I thought I'd share. Would love to get some opinions by those smarter and more well read than myself. ... Looking at you CFC and GF

Not to mention the wonders it works with tendons. This stuff should be as prevalent as testosterone in BB/PL. Also also... https://www.ncbi.nlm.nih.gov/pubmed/17947589 ... For those who are balding
 
Last edited:
I actually was just about to start reading into this. Now I definitely have to. Good find! Basically seems to be a jack of all trades compound when it comes to health.
 
Like a lot of these drugs, it sounds great - but finding a good source is almost impossible. I stopped using "research chemical" stores when I would get bunk AIs. The same was also true with HGH related compounds. To me, it's just not worth the risk or cost. I only rarely will use HGH, but if I do - I'm going straight for the Pfizer pens, the cost be damned. Same thing with AIs, it is very easy to get pharma grade product.

If they are willing to fake the simple stuff, I imagine TB500 is almost ALWAYS fake.

The best advice I can give for heart protection is use trimetazidine while on cycle (and perhaps constantly if you have no side effects) and consider using long acting nitroglycerin when you lift. It's amazing how many people consume crazy preworkout supplements with grey market amphetamine and fake "nitro" vasodilators, when you buy pharma grade nitroglycerin for mere pennies from online pharmacies.
 
Very interesting, thanks for posting, just reading the full papers now.. :)
 
TB500 is good stuff, used it to heal up a partial tricep tear a while back. Increased availability and reliability would definitely be a plus though
 
Eryximachus said:
Like a lot of these drugs, it sounds great - but finding a good source is almost impossible. I stopped using "research chemical" stores when I would get bunk AIs. The same was also true with HGH related compounds. To me, it's just not worth the risk or cost. I only rarely will use HGH, but if I do - I'm going straight for the Pfizer pens, the cost be damned. Same thing with AIs, it is very easy to get pharma grade product.

If they are willing to fake the simple stuff, I imagine TB500 is almost ALWAYS fake.

The best advice I can give for heart protection is use trimetazidine while on cycle (and perhaps constantly if you have no side effects) and consider using long acting nitroglycerin when you lift. It's amazing how many people consume crazy preworkout supplements with grey market amphetamine and fake "nitro" vasodilators, when you buy pharma grade nitroglycerin for mere pennies from online pharmacies.
Click to expand...

Where the hell did this guy come from?? I like him. Interested on why nitroglycerin??? Just not something you hear being used
 
Serotonin101 said:
Where the hell did this guy come from?? I like him. Interested on why nitroglycerin??? Just not something you hear being used
Click to expand...

nitroglycerin...or glycerin tri nitrate (GTN) as it's known medically is a vasodilator (a very powerful one) used by paramedics in the treatment of angina or suspected MI.

It's not something to be fucked with....it will give you a head ache like you wouldn't believe...

and yes it's the same thing that is used to make dynamite....just in somewhat smaller amounts....and in a form that's more stable so you don't blow your head off (literally)...

Don't use GTN as a pre workout.......please
 
Last edited by a moderator:
Backfromthebrink said:
nitroglycerin...or glycerin tri nitrate (GTN) as it's known medically is a vasodilator (a very powerful one) used by paramedics in the treatment of angina or suspected MI.
It's not something to be fucked with....it will give you a head ache like you wouldn't believe...
and yes it's the same thing that is used to make dynamite....just in somewhat smaller amounts....and in a form that's
more stable so you don't blow your head off (literally)...
Don't use GTN as a pre workout.......please
Click to expand...

The organic nitrates are not terribly dangerous drugs. PETN (penta-erythritol tetranitrate) is easily
the best of the bunch, but strangely it is no longer available in the U.S.

But instead of those, for performance enhancement the NO/cGMP pathway can be stimulated
with PDE5 inhibitors -- our old friends sildenafil, tadalafil and etc.

snippet:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023705/
"Downstream interventions may promote NO signalling more
effectively. Activity of the NO/cGMP pathway can be enhanced
by pharmacological blockade of phosphodiesterase 5 (PDE5), the
enzyme that degrades cGMP. Two commercial PDE5 inhibitors are
approved for human use (sildenafil/Viagra; tadalafil/Cialis)
and have been tested in healthy subjects for exercise-related
actions. The strongest evidence that PDE5 inhibition might
improve performance is from Sheffield-Moore et al. (2013) who
showed that short-term, daily administration of sildenafil
increases muscle protein synthesis and reduces muscle fatigue.
Consistent with this finding, tadalafil has been shown to
increase time-to-peak power during anaerobic testing (Guidetti
et al. 2008 ) and sildenafil improved time-trial performance
during cycling in normobaric hypoxia (Hsu et al. 2006).
However, cycling performance was not altered by PDE5
inhibitors in at least one study of healthy subjects under
normoxic conditions (Di Luigi et al. 2008 )." END QUOTE

That's not to mention that tadalafil has recently been shown to
promote lipolysis and possibly mitigate visceral adiposity:

http://www.ncbi.nlm.nih.gov/pubmed/29202488
Acta Biochim Pol. 2017;64(4):687-691.
Acute tadalafil administration increases plasma fatty acids
without changes in the inflammatory response in healthy men.

PDE5Is. Nice drugs.
 
I would say, so far, PDE5 inhibitors and TB4 show great promise (though sildenafil potentially stiffens some layers of the aorta, which isn't good at all). I have an open mind to their future utility (or lack thereof) in a bodybuilder's arsenal. PDE5 inhibitors can also potentially elevate test levels (eg here).

However, on the whole, neither have been sufficiently tested on suitable populations, which in our case would be trained, already physically fit people and athletes. When they say they've tested on 'healthy' people, that doesn't mean folks like us. When you do that, often supposed benefits seem to confusingly disappear in a puff of smoke. One likely reason is that many of the adaptations these drugs appear to facilitate are mimicking conditions naturally promoted by bouts of intensive exercise. Another issue is to do with duration of treatment - acute doses of something often produce outcomes which the body tends to correct for once used chronically.

Still, definitely compounds worth keeping an eye on :)
 
You must log in or register to reply here.
Top