Lorne???
Bluelight Crew
- Joined
- May 3, 2014
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Ok, time to get started on an updated Benzodiazepine chart... Likely start w/ the common ones, and maybe a couple of RC?€™s...
Anyway, here is a start:
Lorazepam: T1/2 8-25h(10-15m) Lipid Solubility: Low Onset: Slow-intermediate SDU: ~1mg Duration: Medium(4-12h range)
Valium: T1/2 20-50h(m 32~) Lipid Solubility: High- Rapid onset(30-45min, peak typically less than 100min oral; IV almost immediate onset, Rapid peak) Tmax corresponds to peak
Duration: Short-intermediate (3-4h acute, up to ~8h chronic)
Semi active metabolite: Nordazepam; Chronic use only(and even then, it is less potent, so would require moderate-high doses for practical effect) Temazepam and oxazepam are not active metabolites, as they are half as potent as D-Pam itself, and is produced in small amounts
Metabolized via P450, primarily to Nordazepam and inactive metabolites() Nordazepam metabolized to oxazepam(via 3a4/2c19)
Rx?€™ed 3-4x per day/PRN at least twice(BID) depending on use
2,5 and 10mg tablets; SDU: ~10mg /7.5(5-10mg Chronic)
Clonazepam- Long acting NitroBenzo w/ delayed onset and extended duration
T1/2: 15-80h? Mean 30-40h Duration: 7-12h(up to 24h* with large doses or repeat administration)
Lipid solubility- Low SDU ~0.5 (Chronic 0.25-0.5; acute 0.5-75)*
(Has unique effects on serotonin, and is one of a few Benzodiazepines w/ multiple uses(unique)
P450 inactive métabolites(7-aminoclonazepam; 3A4 and, 1A2?)
Dose forms: Tablets and Wafers 1/8th(wafer only) .25(generic only#) 0.5 1mg 2mg
Also injectable solution(apperantly rare)
Alprazolam: Tribenzo, Fast acting with short-intermediate duration
T1/2: 10-15m duration- 3-8h(~4- c5h typical)
Lipid Solubility moderate
SDU: ~0.5mg! (Note that it hits hard and fast, and is an excellent anxiety med for most, so may FEEL stronger)
P.O: Peak <2h onset Fast Sublingual: Tmax 80-170minutes; CR tablets: 0.5, 1, 2 and 3mg-regular .25-0.5-1-2
Try add more later
Tranxene- Prodrug for Nordazepam, almost 100% converted prior to reaching systemic
SDU- 15-20mg (Partial Agonist Nordazepam)
T1/2: 20-100hrs~: Duration 4-12h* Lipid solubility- Moderate? Peak-1-4hr(Nordazepam) Clorazepate Fast Tmax
Clonazolam- TriNitrobenzodiazepine, with a typically fast onset and fairly long duration of action; Note that it is VERY POTENT, and long lasting, and it has effects similar to Clonazepam(counterpart) though with the properties of of a Tribenzo like Xanax, as it hits hard and fast, and is an excellent anxyiolytic; however it is NOT recommended under normal circumstances...
SDU: .25mg(possibly 1/8th mg, or <200micrograms) t1/2: limited data, though seems to be 20-30hrs(m) duration: 8-12hr(dose dependent)
Lipid solubility: unknown, likely moderate
Rapid onset, fast to intermediate peak
Temazepam: Internediate acting hypnotic benzodiazepine with a fast to intermediate onset, and medium duration
Tmax: Varies (1.5-3hr) onset SDU: ~20mg range 15-30
Duration 4-8hrs at clinical doses, sedative/hypnotic upwards of 12 hours with multiple or large doses/7.5, 15 30mg capsules
T1/2: 7-25hr, M~15*
Triazolam- fast acting Tribenzo, sedative hypnotic typically brief duration
T1/2: 2-3h/range 1.5-5hrs 3A4 mediated
moderate BA%, making it VERY potent Via other ROA?€™s(they make .125mg tablets for oral use...) BA% 35-50%* oral, 50%+ sublingual(SL),
SDU- ~0.25-.5 PO
Oxazepam: Slow acting Bzd,t1/2 5-15hrs,SDU 15mg Low solubility(low-moderate) medium duration?(variable)
Librium- Classical Bzd, fast onset; t1/2 5-30h intermediate acting
High solubility Multiple metabolites, partially 3A4 mediated Sdu 10-25mg; (Note that peak effects are delayed due to it being largely a prodrug for multiple metabolites, including DCMP, and Nordazepam; so rapid absorption (Tmax <2hrs) though delayed peak)
Etizolam- fast acting Thienodiazepine; low-intermediate duration of action T1/2 ~3.4h Tmax <2hrs Primary Metabolite Alpha-hydroxyetizolam:t1/2 8.2hrs at steady state; Pharmacologically active,(to some extent) likely contributes to extended duration at steady state
Nitrazepam: Nitrobenzodiazepine, intermediate acting Hypnotic and specialty-anti-convulsant; T1/2 15-40hrs- Tmax ~2hrs Duration 5-10hrs Lipophillicity-Moderate/High: Prototype Nitrobenzodiazepine SDU- 5-10mg
Flunitrazepam:
Adding this because it is detailed and accurately; shall make adjustments when/if it is time