Suboxone question.

[morphcode]

So we know most information about precipitated WD as well as how long till one can "feel effects" of full agonists after administering a suboxone however here is the question.

We know subs do not cover all receptors until one hits a certain mg (around 4) but at low doses; like 1 and 2mg there are still some free receptors that could be filled with other agonists. And this is a common practice for many patients to avoid negative effects etc.

At about 1:00p.m. approx. 2mg of sub was administered, at about 6:30 approx. 5mg of oxycodone was administered. Since some receptors were still open to being filled by the oxycodone would taking more suboxone cause precipitated WD by kicking the small amount oxy that was administered off the receptors it managed to attach to? Or since suboxone was already administered and such a small dose of oxy was administered would it be alright?
Any experiences/opinions are appreciate!

Also if so how much more sub do you think would be an okay dose, another 1-2mg or any amount because there isn't a high likelihood of precipitated WD.

 

[Pickledlemons]

So we know most information about precipitated WD as well as how long till one can "feel effects" of full agonists after administering a suboxone however here is the question.

We know subs do not cover all receptors until one hits a certain mg (around 4) but at low doses; like 1 and 2mg there are still some free receptors that could be filled with other agonists. And this is a common practice for many patients to avoid negative effects etc.

At about 1:00p.m. approx. 2mg of sub was administered, at about 6:30 approx. 5mg of oxycodone was administered. Since some receptors were still open to being filled by the oxycodone would taking more suboxone cause precipitated WD by kicking the small amount oxy that was administered off the receptors it managed to attach to? Or since suboxone was already administered and such a small dose of oxy was administered would it be alright?
Any experiences/opinions are appreciate!

Also if so how much more sub do you think would be an okay dose, another 1-2mg or any amount because there isn't a high likelihood of precipitated WD.

IMO.. just do one or the other.

About the precipitated withdrawals its hard to say. are you a daily user? how much do you use? how long have you been using?

 

[Lorne???]

5mg oxy doesn't compare to 2ng sublingual buprenorphine if done correctly; really you just wasted 5mg oxy, stick to one or the other.

And no, no precipitation wd- You'll be fine, though wait long as can, and take your next bupe dose, and remember sublingual has a longer t1/2 than other routes(paranteral) and takes in general to build up in your system, and reach "steady stat" at which point 2mg will be more effective, and should hold longer. Again stick to one or the other, and once stabilized, you will need to skip a dose or two to make a full agonist worth it, and your tolerance will be increased(likely) and you would need an equivalent dose of the alternative opioid

Hope buprenorphine works out, it is effective in many/most cases

 

[morphcode]

This csn be closed i had my wuwstion amswered. For anyone wondering. It seemed 2mg or less was able to combine with other medications and still have effects, sovmong as the SUBOXONE WAS TSKEN PRIOR TO THR OTHER MEDICATION, althiught 2mg was pushing the limit as far as starting to become a blocker for the agonistic effects of the other substsnces. However about 12 to 24 hrs after ingestion of 2mg< another SUBOXONE dose OR any another full agonist drug could be administered with normal effects.

2mg or less of suboxone did also act somewhat like a potentiator although i wouldn't necessarily call it that. More similar to like taking hydrocodone and oxycodone at the same time.