ontariobuds
Greenlighter
- Joined
- Jan 2, 2013
- Messages
- 18
Good morning everybody,
I have searched high and low and maybe the answer lies within the forums but I guess I suck at searching.
I have used the oven method for the new formulation of OxyNeo and it seems to work great. I wanted to know what chemical causes the tablet to gel up and I have narrowed it down to polyethylene oxide.
I found this article and it states as follows?
"Polyethylene oxide is a nonionic hydrophilic polymer that is insoluble in alcohols. Upon contact with water it forms a viscous gel. Attempts to dissolve the tablets in liquid result in a gummy substance that cannot be injected or snorted. The tablets either do not break, or break into pieces that retain some controlled- release functionality. However, crushing followed by dissolution can release over 75% of the dose, depending on the solvent."
http://www.ohrdp.ca/wp-content/uploads/pdf/OxyNeoLetter.pdf
(it is on the first page under the 'What's New' section)
Does anybody know of a solvent that will dissolve it that can be easily removed from the solution for the intended purposes of injecting and or insufflation?
If I have broken any rules with this posting please feel free to do what needs to be done with this thread.
The oven method is fairly painless but I was just thinking maybe there is an easier method?
Thanks for reading through this,
-Ontariobuds
I have searched high and low and maybe the answer lies within the forums but I guess I suck at searching.
I have used the oven method for the new formulation of OxyNeo and it seems to work great. I wanted to know what chemical causes the tablet to gel up and I have narrowed it down to polyethylene oxide.
I found this article and it states as follows?
"Polyethylene oxide is a nonionic hydrophilic polymer that is insoluble in alcohols. Upon contact with water it forms a viscous gel. Attempts to dissolve the tablets in liquid result in a gummy substance that cannot be injected or snorted. The tablets either do not break, or break into pieces that retain some controlled- release functionality. However, crushing followed by dissolution can release over 75% of the dose, depending on the solvent."
http://www.ohrdp.ca/wp-content/uploads/pdf/OxyNeoLetter.pdf
(it is on the first page under the 'What's New' section)
Does anybody know of a solvent that will dissolve it that can be easily removed from the solution for the intended purposes of injecting and or insufflation?
If I have broken any rules with this posting please feel free to do what needs to be done with this thread.
The oven method is fairly painless but I was just thinking maybe there is an easier method?
Thanks for reading through this,
-Ontariobuds