Yeah I eat a lot of nicotine. And smoke a lot. I once priced, since we're not going to discuss prices, regular 4mg nicotine gum from WalGreens as more expensive than cocaine, by weight.
Anyway I can't find much for this compound being therapeutic (nicotine-wise) for animals other than Rhesus macaques and rats. Somehow it leads to them using less nicotine, but not using more anatabine instead. That makes it sound like it just blocks whatever bell-ringing receptor isoform carries the nicotine satisfaction signal. IOW, they chose macaques, cause monkeys can't tell you they're so depressed they wish they were dead.
I mean, you want me to cut back on smoking, you could cut my hands off and sew my lips shut. It would work, but no one would be happy.
I don't understand the mechanism, if anatabine, like nicotine, also agonizes alpha4beta2 and alpha7 cholinergic receptors. What is it that's supposed to be inhibiting reinforcement? Given there's plenty of human studies on thyroid cancer, Alzheimer's and routine inflammation, they should have done a few on smoking cessation. There's a lot of money still in that market, and the total lack of ads everywhere except forum posts, my hunch is it makes you feel like shit somehow.
And no, anatabine would be damn near free as an abundant tobacco product. Marked up some 10,000X in pill form, if it worked someone would have been rich a long time ago.
But then people do say I'm cynical.